EXPLORATION OF OVERWHELMING CRISIS OF PTSD THROUGH TRAUMA NARRATIVE OF ROXANE GAY'S AN UNTAMED STATE

The 21st century is a tech world undergoing surplus ?uctuations, familiarizing the new era, literature re?ects real life changes, challenges, problems and chaos. Though complications like famine, pandemic, accidents, failures, physical abuses, wars etc., physically gets alright, mind and the repressed memory ?nds a way out and the individual faces the psychological tremor, recollecting and re-living the traumatic moment that causes anxiety and waves of panic. The main objective of this paper is to explore the overwhelming emotional crisis of an individual affected from PTSD and the ruptured life after the traumatic incident through the interesting narrative of Roxane Gay's An Untamed State. The plot revolves around the character Mireille, a lawyer abducted for a huge ransom undergoes severe physical and psychological torture. The real horror of her life and unspeakable trauma explodes when she was released after 13 days. Her devastating bitter experience starts to shake her life stripping her identity and affecting her remarkable life altogether. The novel and the psychological study credibly portray and put forth the intricacies of rape trauma syndrome stricken life and surviving its ?erce pangs.

The world’s first malaria vaccine: Hope and challenge / 中国血吸虫病防治杂志

The RTS,S/AS01 is a subunit malaria vaccine against the pre-erythrocytic stage of Plasmodium falciparum. After over 30 years of research and development and clinical trials, this vaccine has been recommended by the WHO for use among children living in highly malaria endemic areas. Although the RTS, S/AS01 vaccine suffers from problems of a low protective efficacy (about 30%), need of four doses and short duration of protective immunity, this malaria vaccine is expected to save tens of thousands of children’s lives, and avoid tens of millions of malaria cases annually, because there have been tens of thousands of childhood deaths due to malaria recently. The introduction of the RTS, S/AS01 vaccine is therefore, widely accepted as a milestone in the history of battle against malaria, which brings a hope to contain malaria and even eventually eliminate malaria. Although there are still multiple challenges in the development of a satisfactory malaria vaccine, the success of the RTS, S/AS01 malaria greatly facilitates the progress towards the development of parasitic disease vaccines, and a more perfect malaria vaccine deserves expectations.

Development and application of the world’s first malaria subunit vaccine RTS, S/AS01 / 中国血吸虫病防治杂志

On October, 2021, the WHO announced the recommendation of RTS, S/AS01 for use among children living in moderately and highly malaria-endemic areas, which receives global attention. Here, the history of RTS, S/AS01 vaccine development and its role in malaria control are described.

Prospects and reflections on the research and development of next-generation malaria vaccines / 中国血吸虫病防治杂志

Vaccination is one of the most effective intervention for the containment and elimination of infectious diseases. Recently, the world’s first malaria vaccine RTS, S/AS01 was approved by WHO for use among children living in moderately and highly malaria endemic areas of Africa, which brings a hope for the research and development of malaria vaccines. Here, we review the current status of malaria vaccines development and provide a perspective on the development of next-generation malaria vaccines, so as to provide insights into the successful development of malaria vaccines.

Potential challenges for large-scale uses of RTS, S/AS01 vaccine in malaria-endemic areas / 中国血吸虫病防治杂志

RTS, S/AS01 vaccine has recently been recommended by the WHO for large-scale uses in malaria-endemic areas, which is a milestone in the history of the fight against parasitic infections. Nevertheless, RTS, S/AS01 vaccine is not perfect. Hereby, the shortages of RTS, S/AS01 malaria vaccine were discussed, and the potential challenges during the research and development of next-generation malaria vaccines were analyzed.

Initial Prealbumin Level And Ability To Normalize Prealbumin Are Highly Predictive Of Increased Mortality And Morbidity In Elderly Trauma Patients

Prealbumin is a well characterized indicator of nutritional status more recently found to be an inverse inammatory marker. At our urban level 1 trauma center, we sought to study the relationship between malnutrition and outcomes in elderly trauma patients. Using prealbumin as a surrogate marker for nutritional status, we hypothesized that patients with reduced prealbumin on initial evaluation have worse outcomes, and in patients where initial prealbumin that was reduced, ability to correct is associated with improved outcomes. We performed a retrospective cohort study involving 200 consecutive patients over the age of 65 admitted to our trauma service. Based on initial prealbumin, patients were divided into 3 groups - below 5 mg/dL, 5-10 mg/dLand greater than 10 mg/dL. Prealbumin was then re-assessed 4 days after admission and patients were again divided into 2 groups based on ability to normalize prealbumin. Data obtained included age, gender, revised trauma score (RTS), injury severity score (ISS), days on a ventilator, ICU length of stay (ICU-LOS), hospital length of stay (HLOS), survival, initial prealbumin, and ability to correct prealbumin within 4 days after admission. Of the 200 patients enrolled, patients were divided into 3 groups using initial prealbumin - 71 patients below 5 mg/dL, 101 patients 5-10 mg/dL, and 28 patients greater than 10 mg/dL. There were 180 patients who were hospitalized for over a 4 day period. Normalization of prealbumin was achieved in 128 patients while 52 patients did not. Mean age was 79.2 years. RTS was found to be decreased in patients with initial prealbumin below 5 mg/dLin comparison to the other groups (11.3 vs. 11.8 vs. 11.8, p = 0.0002), with greater ISS (25.1 vs. 18.8 vs. 19.7, p < 0.0001), ICU LOS (days) (11.3 vs. 3.9 vs. 3.0, p < 0.0001), ventilator days (7.9 vs. 0.8 vs. 0.1, p < 0.0001), HLOS (days) (17.4 vs 7.8 vs. 7.1, p < 0.0001) and decreased survival (66% vs. 95% vs. 100%, p < 0.0001). Patients with prealbumin corrected within 4 days had lower ISS (19.9 vs. 29.2, p < 0.0001), as well as reduction in ventilator days (0.9 vs. 10.1, p < 0.0001), ICU LOS (days) (4.2 vs. 13.8, p < 0.0001), HLOS (days) (8.3 vs. 21.3, p < 0.0001) and improved survival (94% vs. 63%, p < 0.0001). Prealbumin is able to provide short term information regarding current nutritional status and response to therapy. Recent evidence suggest prealbumin may be a prognostic indicator for risk of malnutrition and inammation in critically ill trauma patients. In management of critically ill trauma patients, prealbumin can provide a valuable clinical indication of response to therapeutic intervention and potentially guide management strategy.

Perfil demográfico y clínico de pacientes traumatizados en una institución de cuarto nivel de complejidad, Medellín 2005-2008 / Demographic and clinical profile of trauma patients: a fourth-level institution, Medellin, 2005-2008

Objetivo: describir el comportamiento demográfico y clínico de los pacientes traumatizados de una institución de cuarto nivel de complejidad que ingresaron entre el 2005 y el 2008. Metodología: estudio descriptivo retrospectivo basado en información de pacientes que ingresaron a urgencias y hospitalización. Se estimaron frecuencias y porcentajes para las variables demográficas y algunas clínicas. Finalmente, se realizó un muestreo aleatorio simple para estimar la puntuación de gravedad de las lesiones (trauma and injury severity score-triss). Resultados: en este período ingresaron 165736 pacientes, de ellos, 57382 correspondieron a ingresos por trauma (35% del total). El sexo masculino y el grupo de edad de 20-29 años fueron los más afectados. La causa de ingreso predominante fue la de accidentes de tránsito, seguida por otros tipos de accidentes (caídas, quemaduras, ahogamientos). Fueron hospitalizados 6721 pacientes, de los cuales fallecieron 278, con tasa de mortalidad global de 4,1. La parte del cuerpo más afectada en estos pacientes fueron las extremidades (42%) y los traumas en cabeza y cuello (19%). Para estimar la triss, se analizaron en total 347 pacientes. El índice de severidad del trauma (iss) calculado fue mayor de 49 en 3,17% de los pacientes analizados. La escala revisada de trauma (rts) promedio fue de 7507. Las cifras de presión arterial sistólica y frecuencia respiratoria presentaron una media de 121,948 mmHg y 18,659 min respectivamente, y en la escala de coma de Glasgow, 30 pacientes obtuvieron un puntaje menor o igual a 8. El total de muertes esperadas correspondió a 17 pacientes y el total de muertes observadas a 19. Finalmente, la triss calculada fue de 1,097...

Objective: to describe the demographic and clinical behavior of trauma inpatients admitted in an institution of fourth level of complexity between 2005 and 2008. Methodology: descriptive and retrospective study based on information from patients admitted to the emergency room and to stay hospitalized. Frequencies and percentages for both demographic and inical variables were estimated. Finally, a simple random sampling was conducted to estimate the trauma and injury severity score (triss). Results: during this period a total amount of 165736 inpatients were admitted; 57382 of them were admitted for trauma (35% Perfil demográfico y clínico de pacientes traumatizados: en una institución de cuarto nivel. Medellín 2005-2008 Facultad Nacional de Salud Pública 243 of the total). The male gender and the 20-29 years of age groups were the most affected by trauma. The predominant cause of admission was traffic accidents followed by other types of accidents (falls, burns, drowning). 6721 patients were hospitalized, 278 of which died while the general mortality rate was 4,1. The most affected body part in those patients was the body limbs (42%) and trauma to the head and neck (19%). In order to estimate the triss, a total amount of 347 patients we analyzed. The estimated triss scored more than 49 for 3,17% of the patients studied, the average was 7,507 rts, the systolic blood pressure and the respiratory rate showed an average of 121,948 mmHg and 18,659 minutes respectively, and according to the Glasgow coma scale, 30 patients scored less than or equal to 8. The total amount of expected deaths was 17 patients and the total amount of observed deaths was 19. Finally, the triss calculated was 1.097...

Early Traumatic Deaths

PURPOSE: In Korea, trauma is the 3rd most common cause of death. The trauma treatment system is divided into pre-hospital and hospital stages. Deaths occurring in the pre-hospital stage are 50% of the total death, and 20% of those are deaths that are preventable. Therefore, the purpose of our study is to calculate the preventable death rates caused by trauma in our current pre-hospital system, to analyze the appropriateness of the treatment of traumatized patients and to draw a conclusions about the problems we have. METHODS: The study was done on traumatized patients who expired at the emergency department from January 1, 2005, to December 31, 2009, at the Korea University Medical Centers in Anam, Guro and Ansan. The data on the patients were reviewed retrospectively based on characteristics, conditions on admission and trauma severity. The patient's RTS (revised trauma score) and ISS (injury severity score) was calculated. Preventable death rate was calculated by TRISS (the trauma score-injury severity score). RESULTS: A total of 168 patients were enrolled. All patients were intubated and underwent CPR. Of the total, 72% patients were male, and traffic accidents were the most common form of trauma (52.4%), falls being second (28.6%). Head injury, solitary or multiple, was the most common cause of death (55.4%). Thirty-eight (38, 22.6%) deaths were preventable. The 22.6% preventable death rate consisted of 15.5% potentially preventable and 7.1% definitely preventable deaths. Based on a logistic regression analysis, the relationship between the time intervals until transfusion and imaging and death was statistically significant in the hospital stage. In the pre-hospital stage, transit time from the site of the injury to the hospital showed a significant relationship with the mortality rate. CONCLUSION: One hundred sixty-eight (168) patients died of trauma at the 3 hospitals of Korea University Medical Center. The TRISS method was used to calculate the preventable death rate, with a result of 22.6%. The only factor that was significant related to the preventable death rate in the pre-hospital stage was the time from injury to hospital arrival, and the time intervals until transfusion and imaging were the two factors that showed significance in the hospital stage. Shortening the time of treatment in the field and transferring the patient to the hospital as quickly as possible is the most important life-saving step in the pre-hospital stage. In the hospital stage, the primary survey, resuscitation and diagnosis should proceed simultaneously.

Clinical Investigation of Isolated Chest Injury

PURPOSE: Injuries are the third leading cause of death in Korea. Isolated chest injury is not uncommon and shows high mortality and morbidity. Several scoring systems are used for triage and stratification for trauma patients, but no standard system is accepted. We aimed to analyze the accuracy of identification of isolated chest injury by using several scoring systems. METHODS: We reviewed a total of 75 patients admitted with isolated chest injury between January 2005 and October 2005. Medical records were reviewed by using the Injury Severity Score (ISS), the Revised Trauma Score (RTS), and the Trauma and Injury Severity Score (TRISS). The scoring systems were compared by using statistics methods. RESULTS: The overall predictive accuracy of the TRISS was 12.5%, 12.0% greater than those of the RTS and the ISS. By using the area under the receiver operating characteristic (AUROC) curve, the TRISS showed an excellent discriminative power (AUROC 0.931) compared to the ISS (AUROC 0.926) and the RTS (AUROC 0.872). CONCLUSION: Compared with the RTS and the ISS, the TRISS is an easily applied tool with excellent prognostic abilities for isolated chest trauma patients. However, the TRISS, the ISS, and the RTS showed high specificity and low sensitivity, so another scoring system is required for triage and stratification of isolated chest injury patients.

Clinical Significance of the Triage-revised Trauma Score in the Triage of Geriatric Trauma Patients

BACKGROUNDS: The mortality of geriatric trauma patients is higher than that of other age groups. However, little research has been done the methods or criteria of triage for geriatric trauma patients. This study evaluated a clinical significance of the triage-revised trauma score(t-RTS) for triage of geriatric trauma patients. METHODS: We retrospectively analyzed clinical data on 528 trauma patients over 65 years of age who were treated from Jan 1999 to Dec 2000. The t-RTS was calculated utilizing the RR(respiratory rate), SBP(systolic BP), and GCS scores and the ISS was abstracted from the final diagnosis. The obtained t-RTS and ISS were evaluated using the measures of sensitivity, specificity, accuracy, and AUC curve. RESULTS: The overall mortality rate was 9%, and there was no significant differences between the survival group and the mortality group according to age and sex. The mean scores of SBP, RR and GCS of the survival group were significantly higher than those of mortality group(p=0.001). The mean of t-RTS and RTS of the survival group were also significantly higher(p=0.001), but the ISS was significantly higher in the mortality group(p=0.001). The t-RTS, RTS, and ISS showed good prediction rates on the ROC curve(p=0.001), and the AUC value was higher in the ISS than in the t-RTS and the RTS. The sensitivity and the accuracy were high in the t-RTS and the RTS, and the specificity was high in the ISS. The t-RTS is less than 10 for a survival probability of 50% or less CONCLUSONS: Implementation of the t-RTS in the triage of geriatric trauma patients in the field and in emergency room would be very useful. The probability of death in geriatric trauma patients is high when the t-RTS is less than 10.

Clinical Analysis of Combined Head and Spine Trauma

Among 1350 craniocerebral trauma patients treated between January 1992 and December 1995. The authors analyzed 25 who had suffered combined head and spine trauma and had been subject to follow up. The ratio of males to females was 4 : 1 ; their ages ranged from less than twenty to over sixty. As clinical parameters, we use of the Glasgow Coma Scale(GCS), Revised Trauma Score(RTS) and Glasgow Outcome Scale(GOS) at discharge, and for clinical statistics, used the chi-square test. The results of the study were as follows : 1) Among craniocerebral trauma patients, the incidence of combined head and spine trauma was 2%(25/1350). 2) In cases with combined craniospinal trauma, the incidence of intracranial hemorrhage and cervical spine injury was 76% and 68%, respectively. 3) Among cases with spinal injury, head trauma combined with cervical spine injury showed the worst outcome (p<0.05). 4) Combined high cervical spine injury showed a poorer outcome than did lower cervical spine injury(p<0.05). 5) Initial GCS was significantly related to initial RTS(p<0.05). 6) At discharge, there was a very highly significant correlation between initial GCS and GOS(p<0.01), but not between initial RTS and GOS(p<0.081). 7) Especially in patients who are unconscious because of head trauma, it is important to investigate the possibility of spinal injury other than that of at cervical level.