Advances of polypeptide fragment of rabiesvirus glycoprotein as a brain-targeting carrier / 中国药理学通报

Polypeptide fragment of rabies virus glycoprotein(RVG)has become one of the most popular polypeptides in drug delivery field,because of its advantages of neurotropiam,penetration of blood-brain barrier and biosafety.Polypeptide fragment of RVG can directly deliver proteins and nucleic acids into brain.Additionally,when polypeptide fragment of RVG couples with drug-loading polymers,nanoparticles or liposomes,it can mediate the latters into brain.The application of the RVG polypeptide fragment provides a safe and effective approach for the treatment of brain diseases with biomolecules,such as chemicals,proteins.plasmids,siRNA,miRNA.

Reliability of Logicon caries detector in the detection and depth assessment of dental caries: An in-vitro study.

Background: Digital radiography has so far not resulted in improved rates of proximal caries detection. Historically, automated caries detection tools have been largely academic. Opinions regarding the performance of the only such commercially available tool, viz., Logicon caries Detector (LCD) have been equivocal. This study was conducted to evaluate the reliability of LCD in the detection and depth assessment of proximal caries. Materials and Methods: Digital images were obtained of 100 proximal tooth surfaces using the Kodak RVG 5000 sensor and analyzed by three observers. The images were then analyzed by the principal investigator using the LCD software. The teeth were then sectioned and magnified photographic images were obtained which were taken as the gold standard. All the grades were entered in proformas and the data were statistically analyzed using the chi-square test. Five parameters of reliability were calculated. Results: The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of LCD for the grade No caries were 33, 96, 73, 82, and 81%, respectively; for the grade Enamel caries were 5, 97, 33, 80, and 79%, respectively; and for the grade Dentin caries were 100, 96, 50, 100, and 96%, respectively. Conclusions: In conclusion, LCD appears to be more reliable in ruling out (both enamel and dentin) caries than in detecting caries.