Research progress of irradiation injuries anti-agents / 中华劳动卫生职业病杂志

Irradiation injuries anti-agents refer to drugs that can inhibit the initial stage of radiation injuries, or reduce the development of radiation injuries and promote the recovery of injuries when used early after irradiation exposure. According to the mechanism of action and the time of intervention, the irradiation injuries anti-agents are divided into four categories: radioprotectors, radiomitigators, radiation therapeutics for external radiation exposure, and anti-agents for internalized radionuclides. In this paper, the research progress of irradiation injuries anti-agents in recent years is reviewed.

THE PROTECTIVE AND THERAPEUTIC EFFECT OF 4-MERCURIC ACETATE ESTRONE ON DOGS WHICH RECEIVED 2.75Gy ~(60)Co ?-RAY IRRADIATION / 第二军医大学学报

4-Mercuric acetate estrone (4-MF1) is one of steroidal estrogens which have hi-her protective and therapeutic effects on dogs receiving 2.75 Gy of 60Co ?-ray iradiation.Among those experimental groups,the group treated with 4-ME1 15 mg i.m. two days before irradiation had the higest protective effect, all 5 dogs survived;The group treated with 4-ME 1 i.m. twice at 6,48 h after irradiation had the best therapeutic effect. The survival rate was elevated 54.4%(9/15), as compared with the control group.The clinical symptoms were milder, survival time of dead animals longer, and the WBC count higher.