Protocolos de selección y estudio del donante y receptor, aplicables a la práctica chilena, en trasplante renal / Screening and selection protocol of donor and recipient in kidney trasplantation, applied to chilean practice

En el trasplante de órganos siempre hay un donante y receptor cuyas voluntades deben ser respetadas y que deben ser estrictamente evaluados desde el punto de vista médico, social, psicológico y moral para determinar la idoneidad de cada uno para recibir la acción médica. En el presente artículo se describen las pautas para estudiar a un potencial donante renal vivo o cadavérico y a los potenciales receptores de un trasplante renal para evitar yerros que compliquen el trasplante o atenten contra normas éticas y científicas básicas universalmente aceptadas que se aplican al trasplante de órganos sólidos en general y de riñón en particular.

Organ transplantation is a medical procedure that should be accomplished by the concurrence of a deceased or living donor and a recipient. Both participants should be submitted to a rigorous screening that includes medical, social, psychological and moral evaluation, before being accepted as donor and recipient. In the present article we describe the worldwide established protocols that must be performed in order to assure the optimal quality of either participant in the donation/acceptation process, in order to avoid mistakes that shade solid organ transplantation in general and kidney transplantation among them.

Re-evaluation of serum and urinary soluble interieukin 2 receptors in diagnosis of acute renal allograft rejection / 中华肾脏病杂志

To re-evaluation of serum and urinary soluble interleukin 2 receptors (sIL-2R) in diagnosis of acute renal allo-graft rejection. Methods A group of renal transplant patients were observed for serum and urinary sIL-2R level with sandwich enzyme immunoassay. Hie expression of IL-2R in tissue sections of renal graft of these cases biopsied at the same time were also investigated. Results sIL-2R levels in serum and urine were significantly higher in groups with rejection and infection compared with no rejection and controls. IL-2R values measured in all intrarenal samples were found to be consistently higher during rejection than in nonrejection conditions. Conclusion (1) Acute rejection group as a whole (in average) showed a much higher level of both serum and urinary sIL-2R. But single measurement of sIL-2R was influenced by many factors such as urinary output, fever and renal function. It can not be relied for the diagnosis of rejection, unless serial assays were made. (2) Expression of IL-2R in renal tissue is a more reliable marker for acute rejection.