1.
International Journal of Pediatrics
;
(6): 292-295, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-496052
RESUMO
The definition of refractory Langerhans cells histiocytosis (LCH) is risk organs (bone marrow, liver, spleen)involvement and the first-line treatment failure.It has a very poor prognosis.The survival depends on timely and effective salvage treatment.Currently the treatment for refractory LCH includes isolated 2-chlorodeoxyadenosine, 2-chlorodeoxyadenosine combined with high-dose cytarabine, indomethacin, hematopoietic stem cell transplantation and targeted therapy.In this paper, the advances in treatment of the refractory LCH in children were reviewed.