RESUMO
Background: With the increasing incidence of renal transplantations and advent of modern imaging techniques in the current era, the knowledge of renal artery variations in their position of origin from abdominal aorta, level of origin from the superior mesenteric artery, pattern of their division towards the renal hilum, and the additional branches from the renal arteries should be well known for preparing renovascular surgical and radiological interventions. Methods: Fifty specimens from 25 adult human embalmed cadavers were taken from the department of anatomy and were studied by dissection method. Morphometric data of the specimens dissected were recorded using vernier calipers. Results: Though morphometric analysis of both the kidneys was studied, it shows no significance from earlier studies. Accessory renal arteries were noted in 24% of cases with equal incidence on both sides. Within accessory, hilar type was most common (14%), followed by inferior polar in 12% and superior polar in 2% of specimens. Accessories in 28.5% specimens gave rise to gonadal arteries and 7.3% specimens to inferior phrenic artery. Conclusion: The results suggest that there are a large number of anatomical variations in the vascularisation of the kidney. The most common incidence is the occurrence of accessory renal arteries. It was rarely found that superior and inferior polar arteries originated from the renal artery. The renal artery diameter is a factor which should be considered as predicting the presence of additional renal arteries.
RESUMO
Objective: To observe the effect of low-dose aspirin on allogeneic chronic allograft nephropathy in renal recipient rats and the possible mechanisms. Methods: Chronic allograft nephropathy model of rats were established and the recipient rats were randomly divided into 2 groups with 10 in each group. Cyclosporine A (5 mg/kg) was administered as a basic treatment one day before surgery to prevent and treat acute rejection. Aspirin therapy group was given oral aspirin (5 mg/kg) daily, and control group were given oral saline 2 ml/d. Animals were sacrificed 8 weeks after operation and the serum creatinine, urea nitrogen levels were determined. Renal histomorphology and immunohistochemistry approaches were used to examine TGF-β1 expression. Results: The severity of pathological lesion, increase of serum creatinine and blood urea nitrogen levels, and expression of fibrosis associated factor TGF-β1 in aspirin therapy group were significantly slighter than those of the saline control group (P<0.05). Conclusion: Low-dose aspirin in addition to routine anti-rejection treatment can be used for treatment of chronic allograft nephropathy in rats, which might be associated with the decreased expression of anticoagulation factor TGF-β1.