RESUMO
Objective To determine whether elevated circulating B-type natriuretic peptide (BNP) or N-terminal B-type natriuretic peptide precursor (NT-proBNP) could predict long-term risks of all-cause mortality,cardiovascular mortality or cardiovascular events among maintenance hemodialysis (MHD) patients.Method Data updated by December 2014 in Cochrane Library,Medline Database,Embase Database,CBMdisc and CEBM/CCD were searched.Related research about the relation of BNP or NT-proBNP and the prognosis of MHD patients were included,regardless of language or whether blind method was used.The data were extracted independently by two reviewers.The methodological quality of trails was assessed by recommended evaluation standard.Statistical analysis was performed with STATA 10.0.Results There were 874 papers found by our search strategy,among which 711 articles were in English and 163 articles were in Chinese.Nineteen papers were eligible according to the inclusion criterion and a total of 6185 cases were included.The Meta-analysis results showed that:(1) Elevated BNP or NT-proBNP was significantly related to increased all-cause mortality (HR:2.64,95％ CI:1.73-4.02);(2) Elevated BNP or NT-proBNP was associated with increased cardiovascular events (HR:5.35-7.04,95％ CI:2.23-22.33).Conclusion BNP or NT-proBNP is a promising prognostic tool to risk-stratify MHD patients.
RESUMO
Objective To investigate the psychological status and related factors in patients with mainte-nance hemodialysis in Huzhou city.Methods 376 cases of maintenance hemodialysis were selected as the research subjects in Huzhou First People's Hospital.The anxiety and depression status in maintenance hemodialysis patients were investigated by issuing questionnaires.To study the relationship between anxiety and depression,gender,age, social support,nutritional status,complications,and in maintenance hemodialysis patients.At the same time,the quality of life was evaluated by SF -36 scale.Results Issuing 376 questionnaires,a total of 373 points,the effective recovery rate was 99.20%.In 373 patients,there were 182 patients (48.79%)with no depression,mild depression in 78 cases (20.91%),moderate depression in 59 cases (15.82%),severe depression in 54 cases (14.48%). 51.21% patients had different degree of depression.Of the 373 patients,there were 123 patients (32.97%)with no anxiety,mild anxiety in 141 cases (37.80%),mild and moderate anxiety in 55 cases (14.75%),moderate anxiety in 33 cases (8.85%),severe anxiety in 21 cases (5.63%).A total of 67.03% patients had different degrees of anx-iety.Huzhou city maintenance hemodialysis,female patients had depression rate of 80.70%,anxiety rate of 65.50%, which were significantly higher than the rate of depression 55.45%,anxiety rate 39.11% in male patients,the differ-ences were statistically significant (P <0.01 -0.05).In maintenance hemodialysis patients,the anxiety and depres-sion status gradually increased with age.Severe malnutrition in maintenance hemodialysis patients,the rate of depres-sion,anxiety rates were 80.65%,90.32%,the rates of depression,anxiety were 44.49%,61.81% in normal and mild malnutrition patients,the differences were statistically significant (all P <0.01).SF -36 scale showed that most of the patients with maintenance hemodialysis patients had poor quality of life,and the function was limited. Conclusion Maintenance hemodialysis patients,the general existence of anxiety and depression in the mental state in Huzhou city.Moreover,the psychological state of the patients is influenced by sex,age,nutrition status,and other factors.In clinical,it is needed to provide effective psychological intervention for patients to improve the quality of life,according to the psychological status and related factors of maintenance hemodialysis patients.