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@#Transfusion Transmissible Infections (TTI) in blood donors continue to be a threat to recipients, therefore, to increase accessibility to infection-free donor blood, voluntary non-remunerated donation has been recommended. This was a retrospective observational study aimed at establishing a data base for transfusion transmissible infections in family replacement and voluntary donors at the Alotau Provincial Health Authority (PHA) Blood Bank Service using donor data recorded from 2015 to 2018. Statistical significance was determined using the chi-square test with p-values of <0.05 considered significant. Ethical clearance was approved by the School of Medicine and Health Sciences Research Ethics Committee. Consent to collect data from the Alotau PHA Blood Transfusion Service and the Blood Bank Laboratory was granted on the 17/06/2019 reference #: RCO1/6/19. A total of 2852 blood donors were analyzed, of which 90% (n=2567) were males and 10% (n=285) were females. Of these, 69% (n=1959) were Family-Replacement-Donors (FRDs) and 31% (n=893) were Voluntary Donors (VDs). Donations by FRDs increased with increasing years from 2015 to 2017 and declined slightly by 1% in 2018. The complete opposite was observed in VDs. TTIs were higher in FRDs than in VDs (20.1% vs 16.8%, p=0.04), in single infections, (18.6% vs 15.2%, p=0.03), infection with HBV (9.9% vs 7.2%, p=0.02), and in those aged over 45 years (2.7% vs 0.1%, p=<0.01). The differences were statistically significant. TTI was significantly higher in male FRDs than VDs (19.1 vs 14.3, p=0.00) and in females, it was significantly higher in VDs than in FRDs (2.5% vs 1.0%, p=0.00). TTIs were significantly high in older male FRDs which seem to indicate that the primary route of transmission in this setting could be mostly sexual. This calls for establishment of effective educational awareness about risk factors in the older population, and promotion of voluntary non-remunerated donations in this setting.
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Introduction: Transmission of infectious diseases through donated blood is of concern to blood safety as transfusion forms an integral part of medical and surgical therapy. Blood transfusion carries the risk of transfusion-transmittable infections including HIV, hepatitis–B etc. Screening of voluntary donors who represent healthy population serves as a predictor for these dreadful diseases in healthy population. Materials and Methods: This retrospective study was conducted at the blood bank of Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru. Data were analyzed for a period of 7 years from January 2011 to December 2017. All voluntary donors including replacement donors of our blood bank were screened for Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) and Syphilis infection by using ELISA. Results: The most common infection was Hepatitis B (0.69%) followed by Syphilis (0.34%) and HIV (0.0736%) and least with HCV (0.04%) in our study. Conclusion: This study has shown a decrease in seroprevalence for HIV and increase in seroprevalence for HCV over 7 years study period.
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Background: Hepatitis B virus, Hepatitis C virus and Human immunodeficiency virus (HIV) are important STDs which can be transmissible to the recipients of blood transfusion. The aim of the present study is to study the seroprevalence of HIV, HBV and HCV infection in the blood among voluntary and replacement donors in HIMS Hassan during 2010 to 2012.Methods: A retrospective study was conducted at blood bank of HIMS, Hassan for the years 2010 to 2012. The donors with Hemoglobin>12gm% for both sexes, weight >50 kg, no history of chronic illness, hepatitis, high risk behaviours were included in the study. All the blood samples collected were screened for HIV, HBV and HCV using ELISA kits. All the blood samples were sent to NACO (national AIDS control organization) and subjected to NAT (nucleic acid test) for detection of antigens. Results compared for both voluntary and replacement donors.Results: Total of 10938 blood donors screened. Majority of the donors were males 95.8% (10484) and belonged to voluntary group 72.8% (7971). The total prevalence of STDS were 0.61% (67). The prevalence of HBV, HCV and HIV was 0.47% (51), 0.04% (4) and 0.11% (12) respectively. Prevalence of STDs was higher among voluntary donors 0.57% (62) compared to replacement donors 0.05 % (5). Statistically significant difference was observed in HBV prevalence in voluntary and replacement donors.Conclusions: Most common STDs in blood donors was HBV followed by HIV and HCV. STDs were mainly seen in voluntary donors compared to replacement donors. Majority of the donors were males.
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En Colombia existe todavía un gran porcentaje de donantes de sangre de reposición; invertir esta tendencia es el reto más importante en materia de seguridad que se plantean hoy los bancos de sangre; pero no se debe desestimar a los donantes de reposición, sino que al contrario deben ser bien evaluados y orientados a que su acto de solidaridad sea realizado con responsabilidad y sinceridad. Objetivo: Determinar la prevalencia de sero-reactividad en donantes voluntarios y de reposición. Materiales y Métodos: Estudio observacional retrospectivo de 209 muestras sero-reactivas,confirmadas por laboratorio de referencia en 34414 muestras obtenidas durante el periodo 2005 - 2010 en un Hospital de referencia del oriente de Antioquia. Resultados: Del total de 34.414 muestras de sangre, fueron reactivas el 0.6% en las que se halló lo siguiente: 58.6% eran donantes voluntarios; la edad promedio fue de 38.6±12.4 años, sin diferencias significativas por sexo y tipo de donante (p>0.05). La infección más prevalente detectada fue la sífilis con 74.5% (n= 155), seguida de la hepatitis B con 13% (n=27). No se hallaron diferencias significativas entre el donante voluntario y el donante de reposición según sero-reactividad (p>0.05). Conclusiones: Se evidencia que seis de cada mil donantes resulta positivo para alguna de las cinco enfermedades infecciosas tamizadas. Llama la atención la prevalencia tan alta de sero-reactividad para sífilis (tres de cada cuatro donantes). En cuanto al VIH se encontró mayor sero-reactividad en donantes voluntarios hombres.
In Colombia there is still a large percentage of replacement blood donors. The biggest challenge in security raises blood banks today is to reverse this trend, but replacement donors cannot be dismissed, instead they have to be thoroughly evaluated and directed to do their act of solidarity with responsibility and sincerity. Objective: To determine the prevalence of zero-reactivity in volunteer and replacement donors. Materials and Methods: A retrospective and observational study of 209 zero-reactive samples confirmed by a reference laboratory in 34414 samples during the period 2005 to 2010 in a reference hospital of east Antioquia. Results: From a total of 34414 blood samples, 0.6% was reactive. The following characteristics were found: 58.6% were voluntary donors, the average age was 38.6±12.4, without significant differences by gender and donor type (p>0.05). The most prevalent infection detected was syphilis with 74.5% (n = 155), followed by hepatitis B with 13% (n = 27). No significant differences were found between the donor and the replacement voluntary donor according to zero-reactivity (p> 0.05). Conclusions: It is shown that six of every thousand donors' tests were positive for any of the five infectious diseases screened. It is surprising the high prevalence of zero-reactivity for syphilis (three out of four donors). Greater HIV zero-reactivity was found in male volunteer donors.