A Prospective Study to Understand the Risk Factors for Anastomotic Leak in Small Bowel Anastomosis

Small intestinal anastomosis is a common GI procedure. Anastomotic leaks increase morbidity, mortality and hospital stay in patients undergoing bowel anastomosis. Understanding the risk factors associated with anastomotic leak not only helps to reduce the incidence of leaks but also to identify the patients who are candidates for creation of stomas. The aim of the study is to define the risk factors associated with anastomotic leak following small bowel anastomosis.METHODSA total of 74 patients who underwent small bowel anastomosis in our study period between September 2016 and December 2019 in Karuna Medical College, Palakkad, were prospectively followed up and divided into two groups, leak and non-leak group depending on occurrence of anastomotic leak. Many host and disease related factors known to influence the outcome of anastomosis were recorded in both groups and compared.RESULTSOut of 74 patients, 40 were males and 34 females. 10 patients were aged more than 60 years. 26 of them had perforation and peritoneal contamination. Out of 74, 67 were emergency surgeries and 7 were elective surgeries. 14 patients were anaemic, 19 were hyponatraemic and 12 were hypoalbunemic. In total, 13 patients developed anastomotic leak. Overall mortality and morbidity was 6.7% (5 patients) and morbidity was 40.5% (30 patients). Mortality in anastomotic leak group was 23% (3 patients).CONCLUSIONSHypoalbuminemia (P value- 0.016) and presence of peritoneal contamination (P value= 0.004) were found to significantly increase the risk of anastomotic leak in the present study. In the presence these risk factors, it is better to consider the patient for diverting stoma in emergency setting and consider improving patient nutritional status in elective setting.

Comparison of Imagiology with Operative Findings in a Case of Intestinal Obstruction

Introduction: The diagnosis of intestinal obstruction is a team work of radiologist and clinician. Acute abdominal conditionsrequire precise radiological diagnosis to achieve excellent results to reduce morbidity and mortality.Aims and Objectives: This study aims to study the various radiographical, ultrasonographic, and contrast-enhancedcomputerized tomography (CECT) findings associated with intestinal obstruction and to study the various causes of intestinalobstruction.Methodology: A prospective study of 50 patients admitted to the Mahatma Gandhi Memorial (MGM) Hospital, Warangal, duringthe period of November 2017–September 2019 with the diagnosis of intestinal obstruction.Results: A clinical study of 50 cases of intestinal obstruction was done at Osmania hospital at Hyderabad during November2017–September 2019. Intestinal obstruction whether in small bowel or large bowel occurs nearly in equal ratio in both sexes.Conclusion: Intestinal obstruction remains still a common and important surgical emergency. Obstruction due to adhesionsincreasing in incidence due to increased abdominal and pelvic surgeries. X-ray erect abdomen and ultrasonography abdomenare able to diagnose intestinal obstruction, but CECT has more sensitivity and specificity in diagnosing the intestinal obstruction.It also helps in the management of the intestinal obstruction.

The Pattern Of Acute Intestinal Obstruction: A Hospital Based Study

BACKGROUND: Intestinal obstruction is a surgical emergency that causes confusion both in the diagnosis and the management. It is related by important disease and mortality. The goal of this study was to classify the etiology, to analyse the methods of performance of acute duodenal obstruction in different age groups, various therapeutic modalities of treatment, to accomplish operative management, anticipate the post-operative complications and outcomes of patients with acute intestinal obstruction. MATERIAL& METHODS: 82 patients of all age groups (except infants) presenting with acute intestinal obstruction were studied between June 2017 and December 2018 in a multispeciality hospital in Eastern India. Patients with history of subacute intestinal obstruction and paralytic ileus were excluded from this study. RESULTS: Males were found to be affected much more than females. Pain abdomen was the most common symptom found in 94% cases followed by distension and vomiting in 86.6% and 68.3% cases respectively. Most common etiology of intestinal obstruction was due to adhesion and bands (40.3%) followed by obstructed hernia (22%) and malignancy (17%). The most common procedure done in intestinal obstruction in present study was release of adhesions and bands (37.8%) followed by resection and anastomosis (26.8%). CONCLUSION: Bowel obstruction continues to be one of the most common abdominal problems faced by general surgeons. Success in the treatment of intestinal obstruction depends largely upon early diagnosis, skilful management and treating the pathological effects of the obstruction just as much as the cause itself.

Accidental Blunt Abdominal Injury Causing Multiple Small Bowel Loops’ Avulsion from the Mesentery and Dismembered Colon

A 50-year-old male, truck driver, met with an accident with blunt steering wheel injury to the abdomen with no external marks ofinjury over the abdominal wall. He had severe abdominal pain with tossing up in bed. As the abdomen showed no external marksof injuries, strikingly, abdominal palpatory findings were prominent with severe tenderness in the left side umbilical and pelvicregions. He had consumed heavy food with liquids within an hour before the accident. He collided with another stationary lorry;thus, he received massive blow to his abdomen with the steering wheel. He displayed the signs of hemorrhagic shock on arrivalto the emergency care. Computed tomography scan confirmed moderate hemoperitoneum with multiple bowel perforations. Onexploratory laparotomy, multiple jejunal and ileal loops were found completely avulsed from the base of the mesentery, makingthem completely devascularized along with dismembered descending colon from the sigmoid. Resection of nonviable smallbowels and end-to-end jejunoileal anastomosis was done. Colocolic anastomosis was performed after adequate descendingcolon mobilization with protective loop ileostomy in the right lower quadrant. The patient had developed wound infection; hence,he was put on daily dressing. Gradually, the patient improved and was discharged with functioning ileostomy.

Analysis on operational safety of chronic radiation intestinal injury / 中华胃肠外科杂志

Objective@#To investigate the safety and efficacy of surgical treatment for chronic radiation intestinal injury.@*Methods@#A descriptive cohort study was performed. Clinical data of 73 patients with definite radiation history and diagnosed clinically as chronic radiation intestinal injury, undergoing operation at Department of Colorectal Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University from January 1, 2012 to February 28, 2019, were reviewed and analyzed retrospectively. Patients did not undergo operation or only received adhesiolysis were excluded. All the patients had preoperative examination and overall evaluation of the disease. According to severity of intestinal obstruction and patients′ diet, corresponding nutritional support and conservative treatment were given. Surgical methods: The one-stage bowel resection and anastomosis was the first choice for surgical treatment of chronic radiation intestinal injury. Patients with poor nutritional condition were given enterostomy and postoperative enteral nutrition and second-stage stoma closure and intestinal anastomosis if nutritional condition improved. For those who were unable to perform stoma closure, a permanent stoma should be performed. Patients with severe abdominal adhesion which was difficult to separate, enterostomy or bypass surgery after adhesiolysis would be the surgical choice. For patients with tumor metastasis or recurrence, enterostomy or bypass surgery should be selected. Observation parameters: the overall and major (Clavien-Dindo grades III to V) postoperative complication within 30 days after surgery or during hospitalization; mortality within postoperative 30 days; postoperative hospital stay; time to postoperative recovery of enteral nutrition; time to removal of drainage tube.@*Results@#Of the 73 patients who had been enrolled in this study, 10 were male and 63 were female with median age of 54 (range, 34-80) years. Preoperative evaluation showed that 61 patients had intestinal stenosis, 63 had intestinal obstruction, 11 had intestinal perforation, 20 had intestinal fistula, 3 had intestinal bleeding, and 6 had abdominal abscess, of whom 64(87.7%) patients had multiple complications. Tumor recurrence or metastasis was found in 15 patients. A total of 65(89.0%) patients received preoperative nutritional support, of whom 35 received total parenteral nutrition and 30 received partial parenteral nutrition. The median preoperative nutritional support duration was 8.5 (range, 6.0-16.2) days. The rate of one-stage intestine resection was 69.9% (51/73), and one-stage enterostomy was 23.3% (17/73). In the 51 patients undergoing bowel resection, the average length of resected bowel was (50.3±49.1) cm. Among the 45 patients with intestinal anastomosis, 4 underwent manual anastomosis and 41 underwent stapled anastomosis; 36 underwent side-to-side anastomosis, 5 underwent end-to-side anastomosis, and 4 underwent end-to-end anastomosis. Eighty postoperative complications occurred in 39 patients and the overall postoperative complication rate was 53.4% (39/73), including 39 moderate to severe complications (Clavien-Dindo grade III-V) in 20 patients (27.4%, 20/73) and postoperative anastomotic leakage in 2 patients (2.7%, 2/73). The mortality within postoperative 30 days was 2.7% (2/73); both patients died of abdominal infection, septic shock, and multiple organ failure caused by anastomotic leakage. The median postoperative hospital stay was 13 (11, 23) days, the postoperative enteral nutrition time was (7.2±6.9) days and the postoperative drainage tube removal time was (6.3±4.2) days.@*Conclusions@#Surgical treatment, especially one-stage anastomosis, is safe and feasible for chronic radiation intestine injury. Defining the extent of bowel resection, rational selection of the anatomic position of the anastomosis and perioperative nutritional support treatment are the key to reduce postoperative complications.

Consensuses and controversies on one-stage resection and anastomosis surgery in patients with acute obstructive colorectal cancer / 中国实用外科杂志

Acute intestinal obstruction is one of the common causes of emergency surgery in patients with colorectal cancer,which is usually with poor prognosis. Surgery is the most important way to relieve obstruction and save the lives. One-stage resection and anastomosis can completely remove the tumor, restore the continuity of the intestine, avoid complications of staged surgery and reduce disease burden,and is supposed to be the most ideal surgery. However,due to certain intraoperative technical difficulties and the risk of anastomotic leakage,it is still controversial whether the one-stage resection and anastomosis surgery can be preferred during emergency exploration.

Comparison of Single Layer Versus Double Layer Continuous Anastomotic Technique for Small Bowel Resection and Anastomosis.

Small intestinal resection and anastomosis is an important surgical procedure. Aims and Objectives : To study efficacy and safety of single layer intestinal anastomosis using non absorbable suture material against conventional double layer anastomosis. Single layer anastomosis will decrease surgery time and minimize incorporation of foreign body [sutures]. Materials and Methods : Present study carried out in Pravara rural hospital, Loni. It is a prospective study of 50 patients who underwent elective and emergency resection and anastomosis of small intestine from May 2004 to Oct 2006. Observations : Majority of patients were in the age group of 40-50 yrs and children. Intestinal obstruction with gangrene was the most common indication for anastomosis. Significant difference was found in recovery and complications between two methods after applying Z-test. Discussion : Forty seven patients required resection and anastomosis and 3 patients operated for ileostomy closure. Single layer anastomosis has superior results as compared to double layer anastomosis of small intestine. Conclusion : Arithmetical means of these endpoints suggest that single layer method offers same or better results than double layer method.

Surgical treatment and early postoperative enteral nutrition of acute obstruction caused by colorectal cancer / 中国综合临床

Objective To investigate the method of surgical treatment of acute intestinal obstruction caused by colorectal cancer,and affirm the feasibility and validity of the new way ofearly precolonic postoperative enteral nutritionafter operation of acute intestinal obstruction caused by colorectal cancer.Methods Retrospective analized the clinical data of 78 cases of acute intestinal obstruction caused by colorectal caner from September 2007 to September 2012 and the incidence of complications (incision infection,intra-abdominal abscess,anastomotic leakage,and pneumonia) was observed.Results Sixty-two patients received radical resection and primary anastomosis.All of them were cured and no death occurred.Two patients had complication of postoperative infection and none suffered from anastomotic or drainage leakage.Conclusion Radical resection and primary anastomosis using Intra-operative colonic lavage are safe and effective methods for patients with colorectal cancer associated with acute intestinal obstruction,and early precolonic postoperative enteral nutritioncould better eliminate perioperative malnourished patients more,reduce operation complication,prevent anastomotic leakage,and increase the success rate of the operation.

Primary resection and anastomosis with intraoperative colonic defecation in left colonic cancer with complete obstruction / 国际外科学杂志

Objective To assess the value of primary resection and anastomosis with intraoperative colonic defecation in the patients with obstructive left colonic cancer. Methods From January 2000 to January 2008, 39 patients undergoing emergency laparotomy for left colonic cancers with complete obstruction were analyzed retrospectively. Results The patients were 25 males and 14 females, with a median age of 68.5 years (range: 57～78 years). The primary tumors were located at splenic flexure (3/7.7%), descending colon (8/20.5%), sigmoid colon (15/38.5%), boundary of sigmoid colon and rectum (8/20.5%), and superior segment of rectum (5/12.8%). Primary resection and anastomosis with intraoperative colonic de-fection were performed in 18 patients with left hemicolectomy, 13 patients with sigmoid colectomy and 8 pa-tients with anterior resection. Early complications included wound infection in 4 patients (wound disruption in 1 patient) and pulmonary infection in 5 patients. One patient complicated with anastomotic leakage and intra-abdominal abscess died of tumor metastasis after reoperation. Another one died of respiratory failure secondary to pulmonary infection. Morbidity and mortality was 25.6% and 5.1% respectively. Conclusion Primary resection with intraoperative colonic defecation can be applied to patients with malignant colonic complete obstruction with good operative results.

Laparoscopic-assisted transanal pull-through resection and anastomosis for ultra-low rectal cancer / 中华消化外科杂志

Objective To investigate the feasibility of laparoscopic-assisted transanal pull-through resection and anastomosis in the treatment of ultra-low rectal cancer.Methods From November 2005 to December 2006,21 patients with ultra-low rectal cancer had undergone laparoscopic-assisted transanal pull-through resection and anastomosis in Southwest Hospital.The perioperative condition,postoperative complications and the result of follow-up were retrospectively analyzed.Results The operation was successfully performed on all the patients.The mean operation time and postoperative hospital stay were(216±25)minutes(170-260 minutes)and(9.4±1.0)days(7-11 days),respectively.The time needed for the recovery of gastrointestina]function was(65±14)hours(38-88 hours).The mean perioperative blood loss was(140±49)ml(80-250 ml).All the patients were followed up for(22±4)months(15-28 months),and no anastomotic bleeding or fistula was observed.Six patients developed mild to moderate anastomotic striclure,1 local recurrence and 1 liver metastasis.Conclusions Laparoscopic-assisted transanal pull-through resection and anastomosis for ultra-low rectal cancer is safe and feasible,and the short-term effect is satisfactory.

One-Stage Resection and Anastomosis of Left Colon Cancer Obstruction

Although the obstruction of the right colon is usually handled by primary anastomosis following resection, fear of the increased incidence of septic complication, especially anastomotic leakage with sepsis has turned surgeons away from doing anastomosis in the face of acute obstruction of the left colon. However, from recent reports, enough experiences have been accumulated to show that primary anastomosis is associated with minimum morbidity and mortality in the acute obstruction of the left colon. We experienced 54 cases of colon cancer obstruction at Holy Family Hospital from January 1988 to December 1997. Twenty six cases of them were right colon cancers, 24 cases were left colon cancers and 4 cases were rectal cancers. We reviewed these three groups for evaluation of the safety of one-stage resection and anastomosis of left colon cancer obstruction. The postoperative complication rate was 18% in right colon obstruction versus 38% in left colon obstruction. The most common complication was wound infection(43%). In using of primary resection and anastomosis, complication of right colon revealed 15% and left colon was 29%. But in a method of primary resection and anastomosis with decompression, complication of right colon was 17% and left colon was 13%. Especially on the left colon, primary resection and anastomosis with decompression revealed lower complication(13%) than that without decompression(67%). The mortality of colon cancer obstruction was 2% but this was a patient who had a poor general condition and took a primary resection and anastomosis without decompression. In cases of left colon cancer obstruction primary resection and anastomosis with decompression of left colon cancer obstruction can be a safe operation method with low morbidity and mortality.