Research progress on Chinese materia medica for reversing tumor multidrug resistance / 中草药

Multidrug resistance (MDR) is the main reason for the failure of cancer chemotherapy and also has long plagued the tumor therapy in clinic. The formation of MDR is a complex process with multi gene, multi factor, multi levels, multi structure, and multi steps. To overcome the MDR in tumor cells and improve the curative effect of anticancer drug have become the focus and key topic in tumor research. Nowadays most Western medicine reversal agents only aim at single resistance mechanism and reversal, but they have many adverse reactions which restrict the clinical use. The treatment of malignant tumor with traditional Chinese medicine (TCM) has its unique advantages and gratifying achievements in clinic, more and more anticancer drugs of Chinese materia medica (CMM) are being excavated, studied, and used. CMM used for the treatment of the disease with the properties of multi-channel, multi link, multi targeted effect, could significantly improve the chemotherapy drugs on tumor cytotoxicity. Many scholars are devoted to TCM reversing MDR in cancer. This paper discusses the mechanism of MDR; The studies on the reversal of MDR of tumor with CMM are reviewed in this paper.

Interferon and Verapamil for the Reversal of Multidrug Resistance in Breast Cancer Cell Line / 中国药房

OBJECTIVE: To investigate the effect of interferon-? and verapamil on the reversal of multidrug-resistance(MDR) in breast cancer cell line.METHODS: Drug-sensitive MCF-7 and ADM-induced MDR phenotypic MCF-7/ADR were taken as in vitro experimental models,which were treated with interferon-? and verapamil in combination or alone,then the cell survival rate,IC50,drug-resistant times and reversal times of different experiment groups were measured by MTT test.The quantitive expression of P-170 on the surface of cells was detected by flow cytometry.RESULTS: Treated by interferon-? and verapamil in combination,the IC50 of adriamycin-resistance was lowered to 0.32 ?mol?L-1,superior to verapamil(1.23 ?mol?L-1) or interferon-?(2.29 ?mol?L-1) alone;the reversal times increased to 51.88 in combination group,superior to interferon-? and verapamil alone(7.25 and 13.49 respectively) and the expression of P-170 were lower than in groups treated with interferon-? and verapamil alone.CONCLUSION: The efficacy of interferon-? and verapamil exhibited a more remarkable efficacy on the reversal of multidrug-resistance(MDR) in breast cancer cell line when used in combination than alone.