RESUMO
Objective: To optimize the compatibility of five rhubarb aglycones (aloe-emodin, rhein, emodin, rhubarb, and physcion) in treatment of cerebral ischemia. Methods: The rats were divided into 14 groups based on uniform design. The rats were subjected to right middle cerebral artery occlusion (MCAO) with the suture-occluded method by Longa. The effect of rhubarb aglycone was evaluated using neurological symptoms and infarction area percentage as indexes. The support vector (SVM) machine model was established for pharmacodynamics prediction of rhubarb aglycone. Results: The model established in this study could predict the drug actions of different combinations. The best compatibility was aloe-emodin 6.6534 mg/kg, rhein 26.0008 mg/kg, emodin 11.0042 mg/kg, chrysophanol 3.8414 mg/kg, and physcion 3.8620 mg/kg. Conclusion: Different compatibilities of rhubarb aglycone are effective in the treatment of ischemia to rats. Uniform design combined with SVM method can be more efficient to realize the dose optimization for rhubarb aglycone prescription.