RESUMO
Objective To investigate the correlation between the rs13266634 C/T SNP of SLC30A8 and T2DM in Jinzhou. Methods Based on case?control study,PCR?HRM was used to identify the genotypes of rs13266634 of SLC30A8 gene in 136 cases of T2DM patients and 145 cases of healthy control in Jinzhou. Results The CC genotypic frequency and C allele frequency in T2DM(38.23%and 61.76%)were higher than those of healthy control(22.07%and 51.03%). Furthermore,there was significant difference in case?control study from the population in Jinzhou(P<0.05). The odds ratio of allele C for T2DM was 1.550(95%CI:1.108?2.169,P<0.05). Conclusion The single nucleotide polymorphism of the rs13266634 locus in SLC30A8gene was correlated with T2DM susceptibility in Jinzhou,and the allele C was a risk allele.
RESUMO
BACKGROUND:Previous studies have found that the susceptibility genes of adiponectin gene and calpain 10 gene of type 2 diabetes are closely related with the incidence of diabetes in Chinese renal transplantation patients. So, are other susceptibility genes of type 2 diabetes also associated with posttransplantation diabetes mel itus? OBJECTIVE:To investigate the association between the zinc transporter solute carrier family 30 member 8 (SLC30A8) gene polymorphism and the posttransplantation diabetes mel itus. METHODS:A total of 97 patients with posttransplantation diabetes mel itus and 301 patents without posttransplantation diabetes mel itus (control group) were selected, and then the SLC30A8 gene rs13266634 genotype was detected with real-time PCR method. The association between gene polymorphism and posttransplantation diabetes mel itus was analyzed with Logistic regression test. RESULTS AND CONCLUSION:There were significant differences in al ele frequencies and genotype distributions of rs13266634 between the patients with and without posttransplantation diabetes mel itus (P<0.05). After adjustments of age, sex, body weight and body mass index, the incidence of posttransplantation diabetes mel itus of the CC genotype patients was 2.108 times to that of the TT genotype patients (odds ratio=2.108, 95%confidence interval:1.075-4.131, P=0.044);and the incidence of posttransplantation diabetes mel itus of the CC+CT genotype patients was 1.862 times to that of the TT genotype patients (odds ratio=1.862, 95%confidence interval:1.049-3.306, P=0.034). The results suggest that the C-al ele in rs13266634 of SLC30A8 gene is the independent risk factor of posttransplantation diabetes mel itus.