Ethical Issues in the Development of Smart Healthcare / 中国医学伦理学

Smart healthcare is the outcome of integration and application of the internet, Internet of things (IOT), big data analysis and artificial intelligence (AI) in the medical field. Smart healthcare has been developed rapidly in China. However, smart healthcare has both advantages and risks, thus, it faces challenges and ethical issues in practice. Technological restrictions of smart healthcare increase the risk of privacy disclosure and delayed treatment. Besides, it also induce some ethical issues.Smart healthcare turns the "justice" issue of regional equity into the population equity of medical benefits. In addition, balancing between humanities and science technology should be considered. Smart healthcare should follow the basic ethical principles and the experience of clinical medical ethics. To give full play to the advantages of smart healthcare, the ethical challenges during its development must be regulated at the legal level, and simultaneously governed through ethical norms and guidance.

Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such drugs. To address this challenge, we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug, specifically 6-diazo-5-oxo-l-norleucine (DON), using a thioketal linkage (TK). This system enables imaging, chemotherapy, photodynamic therapy, and on-demand drug release upon radiation exposure. The optimized prodrug, DON-TK-BM3, incorporating cyanine dyes as the fluorophore, displayed potent reactive oxygen species release and efficient tumor cell killing. Unlike the parent drug DON, DON-TK-BM3 exhibited no toxicity toward normal cells. Moreover, DON-TK-BM3 demonstrated high tumor accumulation and reduced side effects, including gastrointestinal toxicity, in mice. This study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

Adicción a los teléfonos inteligentes en adolescentes tras la pandemia por la COVID-19

Introducción: La pandemia por la COVID-19 trajo consigo cambios en el comportamiento humano y afecciones psíquicas que afectan la salud mental. Objetivo: Estimar la adicción a los teléfonos inteligentes en adolescentes mujeres tras la pandemia por la COVID-19. Métodos: Estudio transversal realizado en noviembre y diciembre del 2022, en una institución educativa pública de Ica, Perú. Participaron 581 adolescentes que respondieron a un cuestionario con variables generales y la Escala de Adicción a los Teléfonos Inteligentes. Se aplicó un análisis estadístico descriptivo y multivariado mediante modelos lineales generalizados de la familia Poisson para evaluar la asociación entre las variables. Resultados: De las participantes, el 21,7 % reveló adicción a los teléfonos inteligentes y el 48,7 % se encuentra en riesgo alto de dependencia. Los conflictos familiares en el hogar (razón de prevalencia ajustada - RPa= 1,41; intervalo de confianza -IC 95 %: 1,00-1,99) y los sentimientos de vergüenza (RPa= 1,44; IC 95 %: 1,01-2,03), se asociaron a mayor adicción a los teléfonos inteligentes. No obstante, el sentimiento de tristeza, ansiedad o depresión y el hecho de sentirse rechazado por la sociedad presentaron asociación, no ajustada. Conclusiones: La adición a los teléfonos inteligentes y el riesgo de padecer este trastorno es alto en las adolescentes; existen variables generales susceptibles de ser modificadas que podrían mermar dicha afección comportamental inducida o potenciada por la pandemia de la COVID-19.

Introduction: The COVID-19 pandemic brought with it changes in human behavior and psychic conditions that affect mental health. Objective: Estimate smartphone addiction in female adolescents after COVID-19 pandemic. Methods: Cross-sectional study, conducted during November to December 2022, in a public educational institution in Ica, Peru. A total of 581 adolescents participated and answered a questionnaire with general variables and the Smartphone Addiction Scale. A descriptive and multivariate statistical analysis was applied using Poisson family generalized linear models to evaluate the association between variables. Results: Of the participants, 21.7% revealed addiction to smartphones and 48.7% were at high risk of dependence on these devices. Family conflicts at home (adjusted prevalence ratio-RPa = 1.41; 95% confidence interval-CI: 1.00-1.99) and feelings of shame (RPa = 1.44; 95% CI: 1.01-2.03), were associated with higher smartphone addiction. However, feelings of sadness, anxiety or depression and feeling rejected by society showed an unadjusted association. Conclusions: Smartphone addiction and risk for this disorder is high in adolescent girls; there are general variables amenable to modification that could diminish such a behavioral condition induced or potentiated by the COVID-19 pandemic.

CHALLENGES IN IMPLEMENTING SMART ENERGY METERS IN INDIA

Introduction: Smart Energy Meter (SEM) is an electronic device used to measure, record and transmit the consumption of electricity, gas or water. The smart energy meter is a vital component of a smart grid, which is an advanced power distribution infrastructure that uses digital communication technology to monitor, control and optimize the ow of electricity between power producers and consumers. India, like other developing countries, faces several challenges in the implementation of smart energy meters. This paper examines the challenges in implementing smart energy meters in India and proposes solutions to overcome these challenges.

Sustainable Urban Planning and Smart City Concept in Haryana

The aim of the present paper is to focus the Sustainable Urban Development or the Smart Cities in relation to Haryana in present Scenario. Sustainability can be defined as the practice of reserving resources for future generation without any harm to the nature and other components. In the recent years, Haryana has seen a natural progression in its development story. As the big villages turning into towns, and towns transforming into cities. But it's the time for the state to transform its cities into smart and sustainable cities for the smart urbanization. Though urbanization brings a lot of challenges that can act as a barrier to growth of urbanization or the smart cities. The people move to urban centers in such of jobs and employments and hopefully the better life. Urbanization is change of residence which is geographically expressed as mobility or migration resulted by a way of life called urbanism. It is the proven fact, that the trend has a straight correlation with growth.

Prevalence of smart phone addiction among medical students

Background: The use of smart phone is very common specially in young individuals. Excessive use leads to smart phone addiction, which may have harmful effect on the health of individuals. Aims and Objectives: The aim of our study is to assess the smart phone usage in 1st-year medical students. Materials and Methods: In this cross-sectional study, we have included 187 students from 1st-year MBBS. Out of which 125 (66.84%) are boys and 62 (33.16%) are girls in age group of 18–22 years. All the data were collected in Google form. We have used smart phone addiction scale long version. The Google form was filled by students who are willing to participate in this study. Result: We have found that out of total 187 students, 96 (51.34%) students having high smart phone use, out of which 68 (54.40%) are boys and 28 (45.16%) are girls while 91 (48.66%) students having low smart phone use, out of which 57 (45.60%) are boys and 34 (54.84%) are girls. Conclusion: The high smart phone usages present in the student can be prevented by specific intervention programs at college level.

A study establishing sensitivity and accuracy of smartphone photography in ophthalmologic community outreach programs: Review of a smart eye camera

Purpose: Diseases affecting the cornea are a major cause of corneal blindness globally. The pressing issue we are facing today is the lack of diagnostic devices in rural areas to diagnose these conditions. The aim of the study is to establish sensitivity and accuracy of smartphone photography using a smart eye camera (SEC) in ophthalmologic community outreach programs. Methods: In this pilot study, a prospective non?randomized comparative analysis of inter?observer variability of anterior segment imaging recorded using an SEC was performed. Consecutive 100 patients with corneal pathologies, who visited the cornea specialty outpatient clinic, were enrolled. They were examined with a conventional non?portable slit lamp by a cornea consultant, and the diagnoses were recorded. This was compared with the diagnoses made by two other consultants based on SEC videos of the anterior segment of the same 100 patients. The accuracy of SEC was accessed using sensitivity, specificity, PPV, and NPV. Kappa statistics was used to find the agreement between two consultants by using STATA 17.0 (Texas, USA). Results: There was agreement between the two consultants to diagnosing by using SEC. Above 90% agreements were found in all the diagnoses, which were statistically significant (P?value < 0.001). More than 90% sensitivity and a negative predictive value were found. Conclusion: SEC can be used successfully in the community outreach programs like field visits, eye camps, teleophthalmology, and community centers, where either a clinical setup is lacking or ophthalmologists are not available.

Heart Smart Diabetes Care

The world is growing smarter day by day, and so is health care. In spite of innumerable inventions and tech-tools, however, we struggle to contain chronic illnesses like diabetes and heart disease. We need to work together and design a rational, scientific and socially sustainable Heart Smart diabetes care ecosystem, with Heart Smart management strategies, to ensure happiness and harmony in persons who live with diabetes.

Health Technology Use in Noncommunicable Disorders: Challenges and Opportunities in India

Health care in India is undergoing a rapid change from its historical focus on acute disease management to a focus more on chronic and continuous care-based model for noncommunicable disorders. Health technology could be a game changer as it has a potential to optimize costs and effectively manage such operations. IT solutions are likely to become an integral part of process management, patient care and the hospital management information system in future. This brief communication describes the key enablers and limitations of using health technology in chronic diseases in developing countries like India.

Heart Smart Diabetes Care

The world is growing smarter day by day, and so is health care. In spite of innumerable inventions and tech-tools, however, we struggle to contain chronic illnesses like diabetes and heart disease. We need to work together and design a rational, scientific and socially sustainable Heart Smart diabetes care ecosystem, with Heart Smart management strategies, to ensure happiness and harmony in persons who live with diabetes.

Construction of an electronic medical record sharing convenience service platform based on blockchain / 中华医院管理杂志

Blockchain technology has the advantages of decentralization, secure sharing and tamper resistance, and high privacy, which can solve the current problem of sharing electronic medical records in medical institutions in China. A tertiary hospital established an electronic medical record sharing services convenience service platform based on blockchain in collaboration with China mobile gansu company in September 2021. The hardware architecture of the platform consisted of a hospital data warehouse, a local front-end computer and a blockchain platform. The functional architecture included platform front-end services, the blockchain electronic medical record archiving and service platform. The technical architecture included the underlying blockchain, service layer, interface layer and application layer, which was embedded with asymmetric encryption technology, hash algorithm, smart contract and other technical means, ensuring data ownership and on-demand, controllable, real-time and secure sharing of data. Since the operation of the platform in September 2021, as of October 2022, a tertiary hospital had accumulated 21 545 patient medical records on the chain. The overall operation of the platform was smooth, achieving reliable storage and secure sharing of patient electronic medical records, providing reference for further promoting the interconnection trusted sharing of electronic medical records in medical institutions in China.

Application of electronic head-mounted display aids in low vision rehabilitation / 中华实验眼科杂志

As society ages and the number of people with low vision grows, the need for low vision rehabilitation for patients is increasing.The electronic head-mounted display (HMD) aids is a new type of low vision aids, which can be divided into different types such as monocular, binocular, virtual reality (VR) and augmented reality (AR). The performance of electronic HMD visual aids is important in their development and evaluation, including improved illumination, contrast ratio, resolution, and expanded vision field.VR devices have higher resolution and richer image modes, which can effectively improve central vision acuity and contrast sensitivity, and are more suitable for static applications.AR devices do not block the patients' habitual field of vision and do not destroy stereoscopic vision, which are more suitable for dynamic applications.With the development of VR and AR display technology in recent years, electronic HMD aids have made great progress in functionality, portability and aesthetics.In most of the research, the application population of electronic HMD aids are patients with low central vision.Electronic HMD aids can improve their visual acuity, contrast sensitivity and reading ability by enlarging pictures, improving illumination and contrast ratio and enhancing contour.For patients with peripheral visual field defects, electronic HMD aids, especially AR devices, can significantly expand their peripheral visual field without blocking original visual field.However, the improvement of electronic HMD aids on daily activities, especially athletic ability, needs further research.This article summarized the types, performance and application progress of electronic HMD aids in patients with low vision.

Comparison of early postoperative visual quality between SMILE and SPT-TransPRK / 中华实验眼科杂志

Objective:To investigate the differences and changes in early postoperative visual quality after small incision lenticule extraction (SMILE) and smart pulse technology-assisted transepithelial photorefractive keratectomy (SPT-TransPRK).Methods:A cohort study was performed.A total of 92 patients (92 eyes) who underwent corneal laser refractive surgery were enrolled in Dalian Third People's Hospital Affiliated to Dalian Medical University from February 2021 to May 2021.The data from the right eye were collected for analysis.The patients were divided into SMILE group (40 patients, 40 eyes) and SPT-TransPRK group (52 patients, 52 eyes). Preoperative, 1- and 3-month postoperative visual acuity were measured to calculate the effectiveness, which was defined as the ratio of postoperative uncorrected visual acuity (UCVA) to preoperative best corrected visual acuity.Refraction was measured by an AR-1 autorefractor.Corneal higher-order aberration (HOA) including total HOA, spherical aberration and coma was measured by Sirius corneal topographer.Objective scatter index (OSI), modulation transfer function cut-off frequency (MTF cut-off), Strehl ratio (SR), simulated contrast visual acuity VA100 (day), VA20 (dusk) and VA9 (night) were measured via OQAS II visual quality analysis system.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of the Dalian Third People's Hospital Affiliated to Dalian Medical University (No.2019-KT-010). Written informed consent was obtained from each subject.Results:There was no significant difference in 3-month postoperative UCVA and effectiveness between the two groups ( Z=0.880, P=0.380; t=0.920, P=0.058). Patients in SPT-TransPRK group showed mild hyperopia 3 months after surgery.Preoperative, 1- and 3-month postoperative total corneal HOA was (0.47±0.18), (0.70±0.22) and (0.74±0.19)μm in SMILE group, and (0.40±0.14), (0.98±0.35) and (0.94±0.22)μm in SPT-TransPRK group respectively, showing statistically significant differences ( Fgroup=13.851, P=0.001; Ftime=29.960, P<0.001). Preoperative, 1- and 3-month postoperative spherical aberration was (-0.20±0.09), (-0.44±0.14) and (-0.44±0.15)μm in SMILE group, and (-0.20±0.10), (-0.71±0.23) and (-0.75±0.20)μm in SPT-TransPRK group respectively, showing statistically significant differences ( Fgroup=31.037, P<0.001; Ftime=48.005, P<0.001). The postoperative total corneal HOA and spherical aberration were increased in both groups compared with before surgery, with statistically significant differences (all at P<0.05). The 1- and 3-month postoperative total corneal HOA and spherical aberrations were smaller in SMILE group than in SPT-TransPRK group, and the differences were statistically significant (all at P<0.05). The 1- and 3-month postoperative coma were increased in both groups compared with before surgery, showing statistically significant differences (all at P<0.05). In SMILE group, 1-month postoperative OSI was higher and 1-month postoperative MTF cut-off, SR, and VA9 were lower than those before surgery, and 3-month postoperative OSI was higher and 3-month postoperative SR and VA9 were lower than those before surgery, showing statistically significant differences (all at P<0.05). In SPT-TransPRK group, 1-month postoperative OSI was higher and 1-month postoperative MTF cut-off, SR, VA100, VA20, and VA9 were lower than those before surgery, showing statistically significant differences (all at P<0.05). There was no significant difference in OSI, MTF cut-off, SR, VA100, VA20, and VA9 between 3 months postoperatively and before surgery in the SPT-TransPRK group (all at P>0.05). There was no significant difference in coma, OSI, MTF cut-off, SR, VA100, VA20, and VA9 between two groups (all at P>0.05). Conclusions:Both SMILE and SPT-TransPRK are effective methods for correcting myopia and they have comparable visual quality.Compared with SPT-TransPRK, corneal total HOA and spherical aberration are smaller after SMILE.

Evaluation of the effect of the traditional ward wisdom upgrade based on the Internet of Things platform / 中国实用护理杂志

Objective:To upgrade the wisdom of traditional wards through the internet of things platform to achieve intelligent and refined management of wards, and to evaluate the effect of the upgrade.Methods:In June 2020, the convenience sampling method was used to selecte two wards of the cardiology department of Shandong First Medical University as the pilot units of the affiliated provincial Hospital to implement the intelligent ward management mode. Based on the principle of easy transformation, easy construction and easy maintenance, on the basis of realizing the full coverage of the internet of things, the hardware and software system were connected to complete the intelligent upgrade of the traditional ward, and the structured observation and semi-structured interview methods were adopted to evaluate the upgraded work efficiency and the use experience of patients.Results:The time spent on vital sign collection and recording, nursing risk assessment and time spent, and signage production and hanging were (4.24 ± 0.87), (4.07 ± 0.86) and 0 min respectively, which were effectively reduced than those before the upgrade (6.50 ± 2.95), (4.73 ± 1.62) and (1.13 ± 0.43) min, with statistically significant differences ( t=8.04, 3.99, 28.96, all P<0.01). The results of semi-structured interviews showed that patients perceived the smart ward as intelligent, saving manpower and waiting time; simple to operate, improving the experience of healthcare workers and patients in using it; and untimely system updates. Conclusions:The wisdom upgrade of traditional wards can help refine patient management, improve work efficiency, and improve the experience of health care workers and patients in using them, which will be continuously improved in future development and can provide practical paths for reference for the wisdom upgrade of similar wards.

Artificial intelligence in wearable electrocardiogram monitoring / 生物医学工程学杂志

Electrocardiogram (ECG) monitoring owns important clinical value in diagnosis, prevention and rehabilitation of cardiovascular disease (CVD). With the rapid development of Internet of Things (IoT), big data, cloud computing, artificial intelligence (AI) and other advanced technologies, wearable ECG is playing an increasingly important role. With the aging process of the population, it is more and more urgent to upgrade the diagnostic mode of CVD. Using AI technology to assist the clinical analysis of long-term ECGs, and thus to improve the ability of early detection and prediction of CVD has become an important direction. Intelligent wearable ECG monitoring needs the collaboration between edge and cloud computing. Meanwhile, the clarity of medical scene is conducive for the precise implementation of wearable ECG monitoring. This paper first summarized the progress of AI-related ECG studies and the current technical orientation. Then three cases were depicted to illustrate how the AI in wearable ECG cooperate with the clinic. Finally, we demonstrated the two core issues-the reliability and worth of AI-related ECG technology and prospected the future opportunities and challenges.

Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing

Smart manufacturing still remains critical challenges for pharmaceutical manufacturing. Here, an original data-driven engineering framework was proposed to tackle the challenges. Firstly, from sporadic indicators to five kinds of systematic quality characteristics, nearly 2,000,000 real-world data points were successively characterized from Ginkgo Folium tablet manufacturing. Then, from simplex to the multivariate system, the digital process capability diagnosis strategy was proposed by multivariate Cpk integrated Bootstrap-t. The Cpk of Ginkgo Folium extracts, granules, and tablets were discovered, which was 0.59, 0.42, and 0.78, respectively, indicating a relatively weak process capability, especially in granulating. Furthermore, the quality traceability was discovered from unit to end-to-end analysis, which decreased from 2.17 to 1.73. This further proved that attention should be paid to granulating to improve the quality characteristic. In conclusion, this paper provided a data-driven engineering strategy empowering industrial innovation to face the challenge of smart pharmaceutical manufacturing.

In vitro activity of imipenem/relebactam against non-Morganellaceae Enterobacterales and Pseudomonas aeruginosa in Latin America: SMART 2018‒2020

Abstract Carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa are being isolated from patient specimens with increasing frequency in Latin America and worldwide. The current study provides an initial description of the in vitro activity of imipenem/relebactam (IMR) against non-Morganellaceae Enterobacterales (NME) and P. aeruginosa infecting hospitalized patients in Latin America. From 2018 to 2020, 37 clinical laboratories in nine Latin American countries participated in the SMART global surveillance program and contributed 15,466 NME and 3408 P aeruginosa isolates. MICs for IMR and seven comparators were determined using CLSI broth microdilution and interpreted by CLSI M100 (2022) breakpoints. β-lactamase genes were identified in selected isolate subsets. IMR (96.9% susceptible), amikacin (95.9%), meropenem (90.7%), and imipenem (88.7%) were the most active agents against NME. Among piperacillin/tazobactam-nonsusceptible NME (n= 4124), 90.4% of isolates were IMR-susceptible (range by country, 97.2 [Chile] to 67.0% [Guatemala]) and among meropenem-nonsusceptible NME isolates (n= 1433), 74.0% were IMR-susceptible (94.1% [Puerto Rico] to 5.1% [Guatemala]). Overall, 6.3% of all collected NME isolates carried a KPC (metallo-β-lactamase [MBL]-negative), 1.8% an MBL, 0.4% an OXA-48-like carbapenemase (MBL-negative), and 0.1% a GES carbapenemase (MBL-negative). Amikacin (85.2% susceptible) and IMR (80.1%) were the most active agents against P. aeruginosa; only 56.5% of isolates were imipenem-susceptible. Relebactam increased susceptibility to imipenem by 22.0% (from 23.9% to 45.9%) in piperacillin/tazobactam-nonsusceptible isolates (n= 1031) and by 35.5% (from 5.5% to 41.0%) in meropenem-nonsusceptible isolates (n= 1128). Overall, 7.6% of all collected P. aeruginosa isolates were MBL-positive and 0.7% carried a GES carbapenemase. In conclusion, in 2018‒2020, almost all NME (97%) and most P. aeruginosa(80%) isolates from Latin America were IMR-susceptible. Continued surveillance of the in vitro activities of IMR and comparator agents against Gram-negative pathogens, and monitoring for β-lactamase changes (in particular for increases in MBLs), is warranted.

A segurança como fator-chave para a cidade inteligente, a confiança dos cidadãos e o uso de tecnologias / La seguridad como factor clave para la ciudad inteligente, la confianza de los ciudadanos y el uso de las tecnologías / Security as a key factor for the smart city, citizens' trust, and the use of technologies

Resumo As cidades inteligentes vêm crescendo ao redor do mundo, impulsionadas por inovações tecnológicas. Com elas surgem diversas oportunidades, mas também novas ameaças à segurança e privacidade do usuário nessa realidade interconectada. Este estudo tem como objetivo investigar a percepção de segurança e confiança na tecnologia por parte dos cidadãos e como esta afeta a propensão ao seu uso e, consequentemente, à vida na cidade inteligente. Para tanto, conduziu-se um survey (n = 601), por meio do método PLS-SEM, para testar as hipóteses formuladas. Os resultados obtidos confirmam que o modelo proposto demonstra ser consistente. As relações "confiança e segurança subjetiva" e "segurança objetiva e privacidade de dados" obtiveram relações mais consistentes, assegurando a forte influência das barreiras "tangíveis" e "intangíveis" da percepção de segurança. Dessa forma, para obter e manter a confiança dos usuários, as instituições por trás da tecnologia precisam estar atentas à opinião deles e da sociedade, de forma a manter uma boa reputação para que possam, assim, perpetuar uma percepção positiva de segurança. Conclui-se, assim, que o conceito de segurança adquire uma nova dimensão no contexto da cidade inteligente por ser um componente crucial para toda a sua base e estar intimamente ligado à tecnologia, além de se apresentar como uma preocupação fundamental para os governos e as entidades que buscam implementar soluções e aplicações do conceito.

Resumen Las ciudades inteligentes están creciendo en todo el mundo, impulsadas por las innovaciones tecnológicas. Con ellas surgen diversas oportunidades, pero también nuevas amenazas a nuestra seguridad y privacidad en esta realidad interconectada. Este estudio tiene como objetivo investigar la percepción de los ciudadanos sobre la seguridad y la confianza en las tecnologías y cómo afectan la propensión a usarlas y, en consecuencia, la vida en la ciudad inteligente. Para ello, se realizó una encuesta (n = 601) utilizando el método PLS-SEM para contrastar las hipótesis formuladas. Los resultados obtenidos confirman que el modelo propuesto resulta ser consistente. Las relaciones 'confianza y seguridad subjetiva' y 'seguridad objetiva y privacidad de datos' obtuvieron relaciones más consistentes, confirmando la fuerte influencia de las barreras 'tangibles' e 'intangibles' de la percepción de seguridad. De esta forma, para obtener y mantener la confianza de los usuarios, las instituciones que están detrás de las tecnologías deben estar atentas a su opinión y a la de la sociedad a los efectos de mantener una buena reputación, para que puedan, así, mantener una percepción positiva de la seguridad. Se concluye que el concepto de seguridad adquiere una nueva dimensión en el contexto de la ciudad inteligente, ya que es un componente crucial de toda su base, estrechamente vinculado a la tecnología además de presentarse como una preocupación fundamental para los gobiernos y entidades que buscan implementar soluciones conceptuales y aplicaciones.

Abstract Smart cities are growing around the world, driven by technological innovations. With them come several opportunities and new threats to our security and privacy in this interconnected reality. This study investigates citizens' perception of security and trust in technologies and how they affect the propensity to use them and, consequently, life in the smart city. Therefore, a survey was conducted (n = 601) using the PLS-SEM method to test the formulated hypotheses. The results obtained confirm that the proposed model proves to be consistent. The relationships between 'trust and subjective security' and 'objective security and data privacy' obtained stronger relationships, confirming the strong influence of the 'tangible' and 'intangible' barriers of the perception of security. Thus, to obtain and maintain users' trust, the institutions behind the technologies need to be attentive to the opinion of their users and society to keep a good reputation and a positive perception of security. The users' opinion is a crucial component of smart cities' entire base, closely linked to technology, and presents as a fundamental concern for governments and entities that seek to implement concept solutions and applications.

Design and Research of Wearable Fall Protection Device for the Elderly / 中国医疗器械杂志

A protective device was designed that can be worn on the elderly, which consists of protective airbag, control box and protective mechanism. The combined acceleration, combined angular velocity and human posture angle are selected as the parameters to determine the fall, and the threshold algorithm and SVM algorithm are used to detect the fall. The protective mechanism is an inflatable device based on CO2 compressed air cylinder, and the equal-width cam structure is applied to its transmission part to improve the puncture efficiency of the compressed gas cylinder. A fall experiment was designed to obtain the combined acceleration and angular velocity eigenvalues of fall actions (forward fall, backward fall and lateral fall) and daily activities (sitting-standing, walking, jogging and walking up and down stairs), showing that the specificity and sensitivity of the protection module reached 92.1% and 84.4% respectively, which verified the feasibility of the fall protection device.

4D bioprinting technology and its application in cardiovascular tissue engineering / 生物工程学报

3D bioprinting technology is a rapidly developing technique that employs bioinks containing biological materials and living cells to construct biomedical products. However, 3D-printed tissues are static, while human tissues are in real-time dynamic states that can change in morphology and performance. To improve the compatibility between in vitro and in vivo environments, an in vitro tissue engineering technique that simulates this dynamic process is required. The concept of 4D printing, which combines "3D printing + time" provides a new approach to achieving this complex technique. 4D printing involves applying one or more smart materials that respond to stimuli, enabling them to change their shape, performance, and function under the corresponding stimulus to meet various needs. This article focuses on the latest research progress and potential application areas of 4D printing technology in the cardiovascular system, providing a theoretical and practical reference for the development of this technology.