The Symptom Improvement of Adjunctive Hypochlorous Acid Nasal Cavity Irrigation in Post-Surgically Intractable Chronic Sinusitis / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Low concentration hypochlorous acid is known for being an endogenous anti-bacterial and anti-viral agent. Saline irrigation has been used as an adjunctive treatment for patients with chronic sinusitis. In this study, we tried to compare the effectiveness of hypochlorous acid and saline nasal irrigation to patients with intractable sinusitis after surgery. SUBJECTS AND METHOD: A total of 35 patients who had a frequent relapse of chronic sinusitis or had persisting symptoms post-surgically were recruited. The experimental group was given hypochlorous acid and saline nasal irrigation, while the control group was given saline nasal irrigation for eight weeks. The curative effects were assessed on the basis of the symptom score, nasal endoscopic score, bacterial culture, and inflammatory cytokines on the first day, fourth week, and eighth week after treatment. RESULTS: A total of 26 participants were assessed. The study finally consisted of 15 patients in experimental group and 11 in the control group. The symptom scores in the experimental group were substantially lower before, and after four and eight weeks of treatment. However, there was no specific difference in symptom score improvement between the two groups. The endoscopic score improved in experimental group (p<0.01). Similar tendencies were shown in the bacterial culture test of both groups. In the experimental group, the values of TNF-alpha, IL-8, and IL-1beta decreased in the fourth week, whereas they increased in the eighth week. CONCLUSION: Hypochlorous acid nasal irrigation may be to used as an alternative adjunctive treatment in addition to saline irrigation.

Effect of saline irrigation used in combination with antimicrobial agents on salivary bacterial counts

INTRODUCTION: The aim of the present study was to investigate the effect of mechanical irrigation in combination with mouthwash of antimicrobial agents on salivary bacterial counts. MATERIALS AND METHODS: This study was performed with a randomized study employing a panel of 40 healthy volunteers (20 males and 20 females) between the age of 26 and 32 years. Volunteers were randomly put in one of four treatment groups. In the first group, 0.2 mL of non-stimulatory saliva was collected from every subjective person. Then, saliva was collected after rinsing with chlorhexidine (CHX) for 1 minute. In the second group, non-stimulatory saliva was collected, and then saliva was collected after rinsing with CHX and irrigation with saline. In the third and fourth groups, the same procedures as the first and second groups were performed with povidone iodine (PVI) instead of CHX. All of these samples were cultured for 48 hours aerobically. The reduction rates of colony-forming units (CFU) were calculated for each group. The reduction rate between each group was tested statistically using student t-test. RESULTS: Using CHX in combination with saline irrigation showed a significant decrease of the salivary bacterial CFU when compared with only using CHX.(P0.01) CONCLUSION: It was concluded that the CHX or PVI used with saline irrigation made the salivary bacterial counts reduced more than when CHX or PVI was used alone as an oral antiseptic agent.

Sinus bradycardia following saline irrigation of the pleural cavity during a video-assisted thoracoscopic surgery: A case report / 대한마취과학회지

A 43-year-old man underwent lipoma excision operation with video-assisted thoracoscopic surgery (VATS). Upon completion of the surgery, 20degrees C cold saline irrigation was performed to clean the surgical field. During this procedure, a sudden sinus bradycardia (33 beats/min) occurred. After interruption of the irrigation, the normal sinus rhythm returned spontaneously. With the suspicion that the cold saline could have induced the bradycardia, 40degrees C warm saline irrigation was performed; however, the repeat sinus bradycardia occurred again. The saline irrigation was stopped and the heart rate returned to normal. We conclude that although warm saline irrigation is a common practice after surgical procedures to ensure hemostasis and to clean the surgical field, it may induce profound sinus bradycardia.

Clinical evaluation of cooled radiofrequency ablation for arrhythmias by saline irrigation catheter / 重庆医科大学学报

Objective:To evaluate the safety and efficacy of cooled radiofrequency(RF)ablation for arrhythmias by saline irrigation catheter.Methods:Twenty-six patients with arrhythmia underwent cooled RF ablation by saline irrigation catheter after failure of conventional catheter RF ablation.5cases were with a right-and 1 case with a left-sided resistant accessory pathway,5 cases were with atrial tachycardia,5cases with typeⅠatrial flutter,6 cases with paroxysmal atrial fibrillation,and 4 cases with idiopathic ventricular tachycardia.The ablation parameters were compared between saline irrigation catheter RF ablation and conventional catheter RF ablation.The safety and efficacy of cooled RF ablation by saline irrigation were recored and the average duration of follow-up was 15.8?7.5 months.Results:①There were higher peak electrode temperature,impedance,and lower RF power with conventional catheter electrode than with saline irrigation electrode,and there was no difference in the ablation duration.②Acute successful rate of cooled RF ablation by saline irrigation was 100%(26/26),and long-time successful rate was 88.5%(23/26).③A stroke occurred in 1case,and eschar formed on the catheter electrode in 6 cases with conventional catheter electrode.No complications occurred with saline irrigation electrode.Conclusions:Cooled RF ablation by saline irrigation catheter had good efficacy and high safety in treating arrhythmias,especially for those located deep.