Cirugía endoscópica nasal en el tratamiento de papiloma invertido: a propósito de 18 casos / Endoscopic sinus surgery in the management of inverted papilloma: an analysis of 18 cases

RESUMEN Introducción El papiloma invertido nasosinusal es un tumor benigno con tendencia a la recidiva, y con riesgo de malignización. El tratamiento habitual es la extirpación quirúrgica. Objetivo Describir y analizar las características clínicas, epidemiológicas, y resultados del tratamiento quirúrgico por vía endoscópica. Material y método Estudio retrospectivo, descriptivo, incluyendo pacientes con papiloma invertido nasosinusal sometidos a extirpación quirúrgica endoscópica entre los años 2012 y 2016. Se analizaron variables epidemiológicas, clínicas, complicaciones quirúrgicas, recurrencias y transformación maligna. El grado de extensión se evaluó con tomografia computarizada según la clasificación de Krouse. Resultados La serie está constituida por 18 pacientes, con una edad promedio de 57,4 años. La clínica se caracterizó por obstrucción nasal unilateral 72,2% (13/18 pacientes), rinorrea 33,3% (6/18 pacientes), hiposmia 27,8% (5/18 pacientes) y epistaxis 27,8% (5/18 pacientes). Según la clasificación de Krouse, las lesiones iniciales se describen como estadio T1 en 7/18, T2 en 5/18, T3 en 5/18 y T4 en 1/18 pacientes. En el período de seguimiento, se observa recurrencia en 4 pacientes en un período promedio de seguimiento de 5,6 meses, y un caso de transformación maligna. No hubo complicaciones quirúrgicas, excepto un caso de epífora por obstrucción de la vía nasolagrimal. Conclusiones El abordaje endoscópico fue efectivo para el tratamiento de papilomas invertidos nasosinusales.

ABSTRACT Introduction Sinonasal inverted papillomas are benign tumors with a tendency to recur and a potential for malignant transformation. Surgical resection is the treatment of choice. Aim To describe and analyze the clinical characteristics, epidemiology, and surgical results from an endoscopic endonasal approach. Material and method Retrospective and descriptive study of all patients who underwent endoscopic sinus surgery for the treatment of a sinonasal inverted papilloma between the years 2012 and 2016. Variables analyzed include demographics, signs and symptoms, surgical complications, recurrence rate and malignant transformation. Tumor extension was evaluated with the Krouse staging system on computed tomography imaging. Results This series includes 18 patients, with a mean age of 57.4 years. Clinically, patients presented with unilateral nasal obstruction 72.2% (13/18 patients), followed by rhinorrhea 33.3% (6/18 patients), hyposmia 27.8% (5/18 patients) and epistaxis 27.8% (5/18 patients). Based on the Krouse staging system, 7/18 were T1, 5/18 were T2, 5/18 were T3 and 1/18 was T4 on initial evaluation. On follow-up, 4 patients presented with a recurrence at a mean period of 5.6 months, and one patient exhibited malignant transformation. No surgical complications were observed except for one case of epyphora as a consequence of nasolacrimal obstruction. Conclusions The endoscopic approach was effective for the treatment of sinonasal inverted papillomas.

Relation between periapical lesions and sinus membrane thickening assessed by cone beam computed tomography

The aim of this study was to evaluate thickening of the Schneiderian membrane and to determine its association with periapical pathologies, using computerized cone beam tomo graphy. An observational, analytical, crosssectional retrospective study was conducted. A total 179 maxillary sinuses were evaluated using CBCT. The presence of sinus membrane thickening and its association with unhealthy teeth was analyzed. Results are shown as percentages with 95% confidence intervals (95%CI); Chi square test was used with a significance level of 5%. Sinus membrane thickening was detected in 70 cases (39%; 95%CI=32% to 46%) and no sinus membrane thickening was observed in 109 (61%; 95%CI =54% to 68%) (p<0.05). The 70 cases showing sinus membrane thickening included 46 of odontogenic origin (66%; 95%CI =54% to 76%) and 24 (34%; 95%CI =24% to 46%) of non odontogenic origin (p<0.05). The frequency of odontogenic causes followed a heterogeneous distribution (p<0.05): penetrating caries, failing endodontic therapy, root remnants, deep restorations, implants, periodontal pathology. The main cause was caries (46%; 95%CI=32% to 60%) followed by failing endodontic therapy (26%, 95% CI=16% to 40%). The frequency distribution of involved teeth was uneven (p<0.05), with tooth 16 (33%; 95%CI=21% to 47%) being the most frequently involved, followed by tooth 26 (30%; 95%CI=19% to 45%). The high incidence of sinus pathology of odontogenic origin shows the need for interdisciplinary work involving dentists and earnosethroat specialists. Caries, inadequate restorations, periodontal lesions, implants, and the presence of root remnants are the main causes of Schneiderian membrane thickening. The use of CBCT for diagnosis and treatment planning allows detecting maxillary sinus membrane thickening and determining its association with an odontogenic etiology (AU)

El objetivo del presente trabajo fue evaluar el engrosamiento de la membrana de Schneider y determinar su asociación con patologías periapicales, mediante tomografía computarizada cone beam (CBCT). Se realizó un estudio observacional, analítico, retrospectivo y transversal. Un total de 179 senos maxilares fueron evaluados utilizando CBCT. Se analizó la presencia de engrosamiento de la membrana sinusal y su asociación con piezas dentarias sin vitalidad pulpar. Los resultados se muestran como porcentajes con intervalos de confianza del 95% (IC del 95%). Se utilizó la prueba de Chi cuadrado con un nivel de significación del 5%. Se detectó engrosamiento de la membrana sinusal en 70 casos (39%; IC del 95% = 32% a 46%) y no se observó engrosamiento de la membrana sinusal en 109 (61%; IC del 95% = 54% a 68%) (p < 0.05). Los 70 casos que mostraron engrosamiento de la membrana sinusal incluyeron 46 de origen odontogénico (66%; IC del 95% = 54% a 76%) y 24 (34%; IC del 95% = 24% a 46%) de origen no odontogénico (p <0,05). La frecuencia de las causas odontogénicas siguió una distribución heterogénea (p <0.05): caries penetrantes, tratamiento endodóntico deficiente, restos radiculares, restauraciones profundas, implantes, patolo gía periodontal. La principal causa fue la caries (46%; IC 95% = 32% a 60%), seguida por endodoncia deficiente (26%, IC 95% = 16% a 40%). La frecuencia se distribuyó en forma heterogénea entre las distintas piezas (p<0,05). Las piezas más afectadas fueron la 16 (33%; IC95=21% a 47%) y la 26 (30%; IC95=19% a 45%). La alta incidencia de patología sinusal de origen odontogénico implica la necesidad del trabajo interdisciplinario entre odontólogos y otorrinolaringólogos. Caries, restauraciones inadecuadas, lesiones periodontales, implantes y la presencia de restos radiculares son las principales causas del engrosamiento de la membrana de Schneider. El uso de CBCT para el diagnóstico y la planificación del tratamiento permite detectar el engrosamiento de la membrana del seno maxilar y determinar su asociación con una etiología odontogénica (AU)

Regeneração óssea na região posterior da maxila para instalação de implantes dentários / Regeneración del hueso en la región posterior del maxilar para la instalación de implantes dentales / Bone regeneration in the posterior maxillary region for installation of dental implants

Introdução: regeneração óssea da região posterior da maxila, é um recurso importante para possibilitar a localização correta dos implantes e assim permitir uma adequada reabilitação protética. Várias técnicas cirúrgicas são relatadas, desde a forma de acesso ao seio, elevação da membrana de Schneider e preenchimento da cavidade. Objetivo: abordar os recursos que vem sendo utilizados na cirurgia de regeneração óssea da região posterior da maxila bem como a efetividade dos métodos aplicados. Métodos: foi realizada uma busca eletrônica da literatura, nas bases de dados LILACS, MEDLINE e BBO de estudos publicados na língua inglesa e portuguesa. Como critérios de inclusão foram considerados artigos entre o ano 2000 e 2014, sendo que as palavras chaves que orientaram a busca foram: maxillary bone regeneration, Schneiderian membrane, maxillary sinus lift. Foram obtidos 1 529 artigos, dos quais selecionados 27 artigos relevantes para o estudo em questão. Como critérios de exclusão foram eliminados artigos no qual se encontravam no ano abaixo de 2008 e que fugiam do assunto em questão. Análises e integração da informação : encontrou-se que a técnica tradicional de acesso ao seio maxilar com uso de brocas, elevação da membrana, por meio de curetas, e a regeneração propriamente dita com enxerto ósseo autógeno e/ou heterógeno continuam como as mais utilizadas, no entanto alternativas menos invasivas como tecnologia ultrassônica para fazer acesso, hidrodissecção para elevar a membrana Schneider e biomateriais para preencher a cavidade surgem como opções viáveis e com resultados favoráveis. Conclusões: existe um direcionamento na busca por métodos e materiais que diminuam a morbidade da técnica tradicional e que ofereçam resultados satisfatórios a curto e a longo prazo. A utilização de técnicas cirúrgicas menos invasivas e uso de biomateriais estão entre os avanços para a regeneração da região posterior da maxila(AU)

Introducción: la regeneración ósea de la región posterior del maxilar es un procedimiento importante que permite la correcta colocación de los implantes dentales y una adecuada rehabilitación protésica. Se describen varias técnicas quirúrgicas que van desde la forma de acceder al seno maxilar, el levantamiento de la membrana de Schneider hasta el relleno de la cavidad. Objetivo: abordar los recursos utilizados en la cirugía de regeneración ósea de la zona posterior del maxilar y la efectividad de los métodos aplicados. Métodos: se realizó una revisión bibliográfica en las bases de datos LILACS, MEDLINE y BBO en busca de estudios publicados en inglés y portugués. El criterio de inclusion abarcó los artículos publicados entre los años 2000 y 2014 y las palabras claves que orientaron la búsqueda fueron: regeneración del hueso maxilar, membrana de Schnneider y elevación del seno maxilar. Se encontraron 1 529 artículos de los cuales se seleccionaron 27 con contenido relevante para el estudio en cuestión. En cuanto a los criterios de exclusion, se eliminaron los artículos publicados antes del 2008 y que no se asociaban mucho con el tema referido. Análisis e integración de la información: se halló que la técnica tradicional de acceso al seno maxilar con el uso de brocas, el levantamaiento de la membrana de Schnneider por medio de curetas y la regeneración como tal mediante injertos óseos autógenos y/o heterógenos siguen siendo los procedimientos más utilizados. Por otra parte, alternativas menos invasivas como la tecnología del ultrasonido para lograr acceso, la hidrodisección para levantar la membrana de Schneider y el empleo de biomaterials para rellenar la cavidad emergen como opciones viables con resultados alentadores. Conclusiones: existe una orientación hacia la búsqueda de métodos y materials que disminuyan la morbilidad de las técnicas tradicionales y ofrezcan resultados satisfactorios a corto y a largo plazos. Las técnicas quirúrgicas menos invasivas y el uso de los biomateriales se encuentran entre los avances de hoy día para la regeneración de la zona posterior del maxilar(AU)

Introduction: bone regeneration of the posterior maxilla is an important feature to enable correct placement of implants and thus allow an adequate prosthetic rehabilitation. Several surgical techniques are reported, since the form of access to the sinus, elevation of Schneider membrane and fill the cavity. Objective: to address the resources used in bone regeneration surgery of the posterior maxilla and the effectiveness of the methods applied. Methods: an electronic search of the literature was performed in the databases LILACS, MEDLINE and BBO studies published in English and Portuguese. The inclusion criteria were considered articles between 2000 and 2014, with the key words that guided the search were: maxillary bone regeneration, Schneiderian membrane, maxillary sinus lift. 1 529 articles were obtained, of which 27 selected articles relevant to the study. Exclusion criteria were eliminated in the articles which were in the year below 2008 and fleeing the matter at hand. Data analysis and integration: it was found that the traditional technique of access to the maxillary sinus with the use of drills, lifting the membrane through curettes, and the regeneration itself with autogenous bone graft and/or heterogeneous continue as the most commonly used, however alternative as less invasive ultrasonic technology to access, hydrodissection to raise the Schneider membrane and biomaterials to fill the cavity emerge as viable, with favorable results options. Conclusions: there is a direction in the search for methods and materials that reduce the morbidity of traditional techniques and which offer satisfactory results in the short and long term. The use of surgical techniques less invasive and use of biomaterials are among the advances for the regeneration of the posterior maxilla(AU)

Manejo endoscópico de papiloma invertido nasosinusal: experiencia de 15 años en Hospital Clínico Regional de Concepción / Endoscopic management of sinonasal inverted papilloma: 15 years experience in Concepción Clinical Hospital

Introducción: El papiloma invertido es uno de los tumores benignos más frecuentes de la región nasosinusal. Los principales problemas en su manejo son la recurrencia y transformación maligna. Su tratamiento es la extirpación quirúrgica. Objetivos: Describir y analizar las caracterfsticas cínicas y epidemiológicas, así como el resultado del tratamiento endoscópico practicado en el Hospital Clínico Regional de Concepción. Material y método: Se realizó un estudio retrospectivo, descriptivo, de todos los pacientes con diagnóstico de papiloma invertido nasosinusal operados vfa abordaje endoscópico entre los años 1997 y 2012. Se analizaron variables epidemiológicas y clínicas, incluyendo análisis de las recurrencias y transformación/asociación a cáncer. Resultados: Se encontraron 57 casos de papiloma invertido nasosinusal, 55 de los cuales se abordaron endoscópicamente, 65,5% hombres, 54,7 años en promedio de edad. La obstrucción nasal fue el principal síntoma. La mayor cantidad se concentró en estadio 2 (47,3%) y 3 (32,7%) de Krouse. Complicaciones relevantes 7,8%, las cuales fueron resueltas sin secuelas. Seguimiento promedio de 4,1 años, con una recurrencia de 5 (9,1%) casos, una persistencia (1,8%). Asociación con carcinoma escamoso en el 5,5% de los casos. Conclusión: La experiencia con la resección endoscópica en el papiloma invertido nasosinusal ha demostrado ser efectiva en nuestro medio, con baja tasa de complicaciones y recurrencias.

Introduction: The inverted papilloma is one of the most common benign tumors of the sinonasal region. The main problems in their management are the recurrence and malignant transformation. Their treatment is surgical removal. Aim: To describe and analyze the clinical and epidemiological characteristics, as well as the results of endoscopic treatment in a tertiary hospital. Materials and methods: A retrospective, descriptive study of all patients with diagnosis ofsinonasal inverted papilloma operated by endoscopic approach between 1997 and 2012 was carried out. Epidemiological and clinical variables were analyzed, including analysis of recurrences and transformation to / association with cancer. Results: 57 cases of sinonasal inverted papilloma were found, 55 of which were endoscopically resected, 65.5% male, 54.7 years old on average. Nasal obstruction was the main symptom. Most of them were in Krouse stage 2 (47.3%) and 3 (32.7%); 7.8% of major complications, which were resolved without sequels. The follow up average was 4.11 years, with a recurrence of 5 (9.1%) cases, and (1.8%) persistence. Association with squamous-cell carcinoma was found in 5.5% of cases. Conclusion: The clinical and epidemiological characteristics do not differ greatly from those reported in the literature. Experience with endoscopic resection in sinonasal inverted papilloma has proven effective in our clinical practice, with a low rate of complications and recurrences, this approach currently being the first choice in most cases.

Techniques for Reparation of Perforations of the Maxillary Sinus Membrane: Article Review

A Case of Recurrent Schneiderian Papilloma of the Lacrimal Sac Invading the Nasal Cavity

A 44-year-old man presented with a history of chronic epiphora, discharge from the right eye, and a palpable mass in the medial canthal area. Irrigation of the lacrimal system revealed bloody discharge. Orbital magnetic resonance imaging (MRI) showed a well-defined heterogeneous enhanced mass filling the lacrimal sac and upper nasolacrimal duct (NLD). A wide excision and surgical biopsy were performed. Histopathology showed the tumor to be an exophytic Schneiderian papilloma with moderate to severe dysplasia. Three months later, the mass was found to be invading the nasal cavity through the NLD. Endoscopic histopathological evaluation confirmed that it was identical to the originally identified papilloma.

Repair of the perforated sinus membrane with a micro-suture technique : Report of cases

A Case of Oncocytic Schneiderian Papilloma in the Maxillary Sinus

Oncocytic Schneiderian papilloma (OSP) is a rare neoplasm of the nose and paranasal sinuses, and is often mistaken histologically for papillary adenocarcinoma or even rhinosporidiosis. Recently, we experienced a case of oncocytic Schneiderian papilloma of the left maxillary sinus developed in 53-year-old female patient. She complained of unilateral nasal obstruction, bloody rhinorrhea and frontal headache. The tumor mass was resected surgically through intranasal endoscopic and Caldwell-Luc's approach. We report its clinical manifestations and histologic characteristics.

p53 Expression in the Head and Neck Tumor

Mutations in the p53 gene seem to be the most common genetic changes in human malignancies. Mutation or altered p53 expression is a common occurrence in many solid neoplasms, including head and neck carcinomas. Recent studies have also shown p53 alterations in several premalignant conditions of the colon, esophagus, lung, and brain. Preliminary data have suggested that p53 mutations may be involved in tumor progression. This study was performed to determine the incidence of p53 mutations in histologically 27 squamous cell carcinomas, 19 basal cell carcinomas, 18 Schneiderian papillomas, 3 Schneiderian papillomas with malignant transformation, and 15 pleomorphic adenomas of the head and neck region. The degree of p53 gene overexpression was also evaluated according to differentiation, histologic type of tumor, and tumor progression in the head and neck carcinomas. The results were as follows; 1) Eighteen of 27 squamous cell carcinomas, and 4 of 27 dysplasias adjacent to the squamous cell carcinoma of the head and neck expressed p53 protein, but none of the normal control specimens expressed detectable p53 protein. There was no relationship between differentiation of squamous cell carcinoma and p53 protein expression. 2) Twelve of 19 basal cell carcinomas expressed p53 protein; the adenoid type especially overexpressed p53 protein. 3) Nine of 15 pleomorphic adenomas expressed p53 protein especially in the epithelial components. 4) Thirteen of 18 Schneiderian papillomas and all Schneiderian papillomas with malignant transformation expressed p53 protein. The above results indicate that the p53 protein expression is a useful tool for the prediction of tumor progression in the head and neck tumor, but there was no relationship between the differentiation of the tumor and p53 protein expression.

Schneiderian Papillomas A Clinicopathologic Study of 27 Cases

Schneiderian papillomas are papillary lesions of the nasal cavity paranasal sinuses that arise from the Schneiderian membrane, a membrane of ectodermal origin embryologically derived from the nasal placodes. This membrane is characterized by transitional type epithelium, similar to bladder urothelium, with admixed microcysts or mucin droplets. It has a tendency to recur after removal and transform into malignancy even though rare. Total 27 cases of Schneiderian papillomas were examined in the Chosun University medical college, which were collected from 1978 to 1986. The results obtained were as follows: 1) There were 19 male and 8 female patients, and mean age at diagnosis was 50.5+/-12.0 (SD) year (27-74 years). 2) Nasal obstruction or perception of nasal mass was the most common presenting symptom; Mean duration of symptoms was 25.8+/-15.0 (SD) month (4-48 months). 3) Numbers of papillomas had predominantly endophytic (inverted, n=17) and predominantly exophytic (fungiofrom n=6) patients, and four had mixed pattern. 4) In 27 patients, recurrences developed in 9, local invasion in one (with an inverted papilloma), and epidermoid carcinoma in one (with an inverted papilloma).