RESUMO
Based on the current situation and development trend of the modernization of traditional Chinese medicine (TCM) theory, combined with three major frontier scientific problems and three major engineering and technical problems needed to be solved, the crux of the modernization problem of TCM was identified, the way to solve the modernization problem of TCM was put forward, and the decisive role of supramolecular "qi chromatography" theory of TCM in cracking these problems was elaborated. The human body and Chinese materia medica are observed clearly in the long history of biological evolution in nature, while supramolecular chemistry has played an important role in analyzing the evolutionary trajectory of life and tracing the origin of TCM theory. In the long process of biological evolution in nature, all kinds of molecules in nature follow supramolecular chemistry, forming supramolecular bodies according to "imprinted template" step by step, from simple to complex, from inanimate inorganic complexes to living enzyme systems, from single simple molecules to complex supramolecular machines, through which the interaction of the biological molecules runs in the chain of organisms composed of supramolecular bodies. Meridians, which are the result of the orderly arrangement of the "imprinted template" channel structure step by step, are the basic form to control molecules. Under the impetus of human heart beating, the small molecules substances dissolved in blood migrate into and act on according to the "imprinting template" embed in main macromolecule of meridians and viscera. It shows the anisotropy of the action of meridians and viscera on small molecules, that is visceral phenomena, on which the essential of life science and the original theory of "principle", "method", "prescription" and "medicine" for TCM will be clarified. Major scientific and engineering problems of TCM will be solved on the basis of supramolecular chemistry, and the basic theory of TCM will be reconstructed and modernized into a union with contemporary medicine.