Efficiency and comparability of using new evidence platforms for updating recommendations: experience with a type-2 diabetes guideline in Colombia / Eficiencia y comparabilidad del uso de nuevas plataformas de evidencia para la actualización de recomendaciones: experiencia con una guía de diabetes tipo 2 en Colombia

INTRODUCTION: Updating recommendations for guidelines requires a comprehensive and efficient literature search. Although new information platforms are available for developing groups, their relative contributions to this purpose remain uncertain. METHODS: As part of a review/update of eight selected evidence-based recommendationsfor type 2 diabetes, we evaluated the following five literature search approaches (targeting systematic reviews, using predetermined criteria): PubMed for MEDLINE, Epistemonikos database basic search, Epistemonikos database using a structured search strategy, Living overview of evidence (L.OVE) platform, and TRIP database. Three reviewers independently classified the retrieved references as definitely eligible, probably eligible, or not eligible. Those falling in the same "definitely" categories for all reviewers were labelled as "true" positives/negatives. The rest went to re-assessment and if found eligible/not eligible by consensus became "false" negatives/positives, respectively. We described the yield for each approach and computed "diagnostic accuracy" measures and agreement statistics. RESULTS: Altogether, the five approaches identified 318 to 505 references for the eight recommendations, from which reviewers considered 4.2 to 9.4% eligible after the two rounds. While Pubmed outperformed the other approaches (diagnostic odds ratio 12.5 versus 2.6 to 5.3), no single search approach returned eligible references for all recommendations. Individually, searches found up to 40% of all eligible references (n = 71), and no combination of any three approaches could find over 80% of them. Kappa statistics for retrieval between searches were very poor (9 out of 10 paired comparisons did not surpass the chance-expected agreement). CONCLUSION: Among the information platforms assessed, PubMed appeared to be more efficient in updating this set of recommendations. However, the very poor agreement among search approaches in the reference yield demands that developing groups add information from several (probably more than three) sources for this purpose. Further research is needed to replicate our findings and enhance our understanding of how to efficiently update recommendations.

INTRODUCCIÓN: La actualización de recomendaciones de las guías de práctica clínica requiere búsquedas bibliográficas exhaustivas y eficientes. Aunque están disponibles nuevas plataformas de información para grupos desarrolladores, su contribución a este propósito sigue siendo incierta. MÉTODOS: Como parte de una revisión/actualización de 8 recomendaciones basadas en evidencia seleccionadas sobre diabetes tipo 2, evaluamos las siguientes cinco aproximaciones de búsqueda bibliográfica (dirigidas a revisiones sistemáticas, utilizando criterios predeterminados): PubMed para MEDLINE; Epistemonikos utilizando una búsqueda básica; Epistemonikos utilizando una estrategia de búsqueda estructurada; plataforma (L.OVE) y TRIP . Tres revisores clasificaron de forma independiente las referencias recuperadas como definitivamente o probablemente elegibles/no elegibles. Aquellas clasificadas en las mismas categorías "definitivas" para todos los revisores, se etiquetaron como "verdaderas" positivas/negativas. El resto se sometieron a una nueva evaluación y, si se consideraban por consenso elegibles/no elegibles, se convirtieron en "falsos" negativos/positivos, respectivamente. Describimos el rendimiento de cada aproximación, junto a sus medidas de "precisión diagnóstica" y las estadísticas de acuerdo. RESULTADOS: En conjunto, las cinco aproximaciones identificaron 318-505 referencias para las 8 recomendaciones, de las cuales los revisores consideraron elegibles el 4,2 a 9,4% tras las dos rondas. Mientras que Pubmed superó a las otras aproximaciones (odds ratio de diagnóstico 12,5 versus 2,6 a 53), ninguna aproximación de búsqueda identificó por sí misma referencias elegibles para todas las recomendaciones. Individualmente, las búsquedas identificaron hasta el 40% de todas las referencias elegibles (n=71), y ninguna combinación de cualquiera de los tres enfoques pudo identificar más del 80% de ellas. Las estadísticas Kappa para la recuperación entre búsquedas fueron muy pobres (9 de cada 10 comparaciones pareadas no superaron el acuerdo esperado por azar). CONCLUSIONES: Entre las plataformas de información evaluadas, Pubmed parece ser la más eficiente para actualizar este conjunto de recomendaciones. Sin embargo, la escasa concordancia en el rendimiento de las referencias exige que los grupos desarrolladores incorporen información de varias fuentes (probablemente más de tres) para este fin. Es necesario seguir investigando para replicar nuestros hallazgos y mejorar nuestra comprensión de cómo actualizar recomendaciones de forma eficiente.

Cambio climático y olas de calor sobre el bienestar subjetivo en jóvenes / Climate change and heat waves that affect the subjective well-being of young people / Mudanças climáticas e ondas de calor no bem-estar subjetivo de jovens

Resumen (analítico) El cambio climático y el aumento de las olas de calor tienen un impacto negativo en el bienestar subjetivo de niños y jóvenes. Este estudio examinó la experiencia de bienestar en jóvenes chilenos frente a las olas de calor. Utilizando entrevistas y grupos focales, se seleccionaron diez participantes con diferentes trayectorias educativas y niveles de contacto con la naturaleza. Los resultados mostraron que predominaban percepciones negativas del clima y emociones displacenteras como preocupación y desmotivación. Sin embargo, se encontró que aquellos con mayor contacto con la naturaleza experimentaban un mayor bienestar subjetivo. Se concluye que las olas de calor asociadas al cambio climático afectan negativamente la salud mental, pero también se destaca el papel que desempeñan los jóvenes en las acciones de mitigación y adaptación ante el cambio climático.

Abstract (analytical) Climate change and the increasing occurrence of heatwaves have a negative impact on the subjective well-being of children and young people. This study examined the well-being of young Chileans during heatwaves. Using interviews and focus groups, ten participants with a range of educational backgrounds and different levels of contact with nature were selected. The results showed that negative perceptions of the climate and unpleasant emotions such as worry and feeling demotivated were prevalent among young people during heatwaves. However, it was identified that young people who have increased contact with nature experienced higher subjective well-being during these climate conditions. The authors conclude that heatwaves associated with climate change negatively affect young people's mental health. However, the role that young people play in climate mitigation and adaptation actions was also emphasized by participants in the study.

Resumo (analítico) A mudança climática e o aumento das ondas de calor têm um impacto negativo no bem-estar subjetivo de crianças e jovens. Este estudo examinou a experiência de bem-estar de jovens chilenos diante das ondas de calor. Utilizando entrevistas e grupos focais, foram selecionados dez participantes com diferentes trajetórias educacionais e níveis de contato com a natureza. Os resultados mostraram que predominavam percepções negativas do clima e emoções desagradáveis como preocupação e desmotivação. No entanto, descobriu-se que aqueles com maior contato com a natureza experimentavam um maior bem-estar subjetivo. Conclui-se que as ondas de calor associadas à mudança climática afetam negativamente a saúde mental, mas também destaca-se o papel desempenhado pelos jovens nas ações de mitigação e adaptação às mudanças climáticas.

Design and implementation of registration system based on Elasticsearch / 中国医学装备

Objective:To design and implement a registration system based on Elasticsearch,so as to solve the problems of the conventional registration system included single method of appointment and registration,and one-sidedness information of search registration platform,and to meet the growing needs of patients for diversified and intelligent medical registration and treatment.Methods:The browser/server(B/S)architecture was used to implement the design of registration system.The front-end used the neuron organic object description language(NOODL)language to render the interface,and implemented interaction between function methods and interface data through Typescript.The Elasticsearch search engine implemented high efficient search functions.The back-end processed the requirements of data through the(edge-based cloud object storage)ECOS system,and stored business data in the MySQL database.The system included a three-layer architecture with application layer,service layer and storage layer,which can realize a series of functions such as login and registration,search for appointments,link appointments,scan code for appointments,and setting appointment information by doctors.Results:The registration system based on Elasticsearch can realize multiple methods of appointment registration such as online search appointment,exclusive link appointment of hospital,appointment by scanning code,etc.,which was suitable to multiple platforms such as Web and mobile device.It has been applied in many overseas medical institutions.As of June 2023,the system possessed 219 doctors,and had serviced for 19,903 patients,and had completed 62,737 appointments,which saved a lot of time for patients to seek medical treatment,and improved operation efficiency of hospital.Conclusion:The registration system based on Elasticsearch can meet the diversified and intelligent needs of patients for medical treatment,which can provide comprehensive,accurate and intelligent services of appointment and treatment for patients,and can effectively improve the efficiency of appointment and treatment.

Extraction Process of Jinlei Compound Based on BAS-BP Neural Network Combined with Entropy Weight Method / 中国中医药信息杂志

Objective To optimize the ethanol extraction technology parameters of Jinlei Compound through orthogonal experiment combined with beetle antennae search(BAS)-back propagation(BP)neural network.Methods On the basis of the optimal extraction concentration obtained by single factor investigation,the ratio of solid to liquid,extraction time and extraction times were set as the orthogonal test factors.The entropy weight method was used to calculate the comprehensive scores of the yield of luteolin,kaempferol,swertianin and dry paste.Then,the BAS-BP neural network model was established,and the optimum extraction process was predicted by the BAS.Results BAS-BP neural network optimized Jinlei Compound alcohol extraction process was as follows:solid-liquid ratio 1:10,extraction time of 0.5 h,extraction times of 3,the comprehensive score was 96.352 6.The optimal process parameters obtained by orthogonal design were:solid-liquid ratio 1:10,extraction for 0.5 h,extraction for 3 times,the comprehensive score 90.988 0.The comprehensive score of BAS-BP neural network model was slightly better than that of orthogonal experiment,but the difference between the two was small.The optimal extraction process of Jinlei Compound was determined by comprehensive production practice as the ratio of solid to liquid 1:10,extraction for 0.5 h,extraction for 3 times.Conclusion The optimized process based on BAS-BP neural network has higher extraction efficiency and good stability,which can provide reference for subsequent development and quality control.

Research Progress of the Infectious Disease Prediction Models Based on Internet Data / 医学信息学杂志

Purpose/Significance The paper systematically reviews relevant research on infectious disease prediction models based on internet data,helps to realize the advancement of infectious disease surveillance,and provides references for the construction of intelli-gent three-dimensional prevention and treatment system of infectious diseases.Method/Process The development history and research direction of infectious disease surveillance and early warning based on internet data collected in the core database of Web of Science and CNKI in the past 20 years are reviewed,major existing problems and challenges are analyzed,and common prediction models and their optimization directions are summarized.Result/Conclusion The study on internet infectious disease surveillance shows the trend of diver-sification of monitoring diseases,refinement and specialization of data sources.Due to the complexity and uncertainty of internet data,most of the existing models are only suitable for short-term or real-time prediction.By constructing a combination model,strengthening multi-source data fusion,improving the selection of keywords and influencing factors,the model can be further optimized and the fitting effect and prediction capacity can be strengthened.

Internet use by pregnant women during prenatal care

ABSTRACT Objective: The search for medical information on the internet is a part of people's daily lives. Exponential volumes of data are available through various media and platforms. There are several problems related to the ease of creating and accessing medical information on the internet, as evidenced by the quantity of false content and increasing anxiety due to the consumption of these data. In light of this accessibility, it is necessary to understand how people use internet-based medical information and its impact on specific populations. This prospective study aimed to analyze pregnant women's behavior when searching for health-related information on the internet, and how they were influenced by the information. Methods: Questionnaires were administered to the participants during their immediate puerperium, and their answers were tabulated. Results: Three hundred and two patients answered the questionnaires. We observed that internet use was frequent, and most patients discussed the findings with their physicians. However, this did not affect the delivery routes. Conclusion: The search for health information by pregnant women is very prevalent but does not interfere with the delivery route.

Inefficacious drugs against covid-19: analysis of sales, tweets, and search engines / Medicamentos ineficazes contra covid-19: análise de vendas, tweets e mecanismos de busca

ABSTRACT OBJECTIVE Assess the correlation between the sales of two drugs with no proven efficacy against covid-19, ivermectin and chloroquine, and other relevant variables, such as Google® searches, number of tweets related to these drugs, number of cases and deaths resulting from covid-19. METHODS The methodology adopted in this study has four stages: data collection, data processing, exploratory data analysis, and correlation analysis. Spearman's method was used to obtain cross-correlations between each pair of variables. RESULTS The results show similar behaviors between variables. Peaks occurred in the same or near periods. The exploratory data analysis showed shortage of chloroquine in the period corresponding to the beginning of advertising for the application of these drugs against covid-19. Both drugs showed a high and statistically significant correlation with the other variables. Also, some of them showed a higher correlation with drug sales when we employed a one-month lag. In the case of chloroquine, this was observed for the number of deaths. In the case of ivermectin, this was observed for the number of tweets, cases, and deaths. CONCLUSIONS The results contribute to decision making in crisis management by governments, industries, and stores. In times of crisis, as observed during the covid-19 pandemic, some variables can help sales forecasting, especially Google® and tweets, which provide a real-time analysis of the situation. Monitoring social media platforms and search engines would allow the determination of drug use by the population and better prediction of potential peaks in the demand for these drugs.

RESUMO OBJETIVO Investigar a correlação entre as vendas de dois medicamentos sem eficácia comprovada no tratamento de covid-19, ivermectina e cloroquina, e outras variáveis relevantes: pesquisas no Google®, número de tweets relacionados aos medicamentos, casos e óbitos decorrentes da covid-19. MÉTODOS A metodologia adotada neste estudo se divide em quatro partes: coleta de dados; processamento dos dados; análise exploratória; e análise de correlação. Foi utilizado o método de Spearman para obter as correlações cruzadas entre cada par de variáveis. RESULTADOS Os resultados mostram similaridade entre os comportamentos das variáveis. Os picos ocorreram em períodos iguais ou próximos. A análise exploratória dos dados apontou que houve falta de cloroquina no período correspondente ao início das divulgações sobre a aplicação desses medicamentos para o tratamento da covid-19. Ambos os medicamentos apresentaram correlação alta e estatisticamente significativa com as demais variáveis analisadas. Também foi observado que algumas delas apresentaram maior correlação com as vendas de medicamentos quando assumiram defasagem temporal de um mês. No caso da cloroquina, isso ocorreu com a variável óbitos. No caso da ivermectina, ocorreu com as variáveis número de tweets, casos e óbitos. CONCLUSÕES Os resultados observados contribuem para a tomada de decisão durante a gestão de crises por parte de governo, indústrias e comércios. Em momentos de crises, como observado durante a pandemia, as variáveis mostraram que são capazes de auxiliar na previsão de vendas, em especial o Google® e os tweets, que proporcionam uma análise em tempo real da situação. Acompanhar as redes sociais e mecanismos de busca permitiria detecção de uso pela população e melhor previsão de potenciais picos de demanda desses medicamentos.

Revisão por pares das estratégias de busca para revisões sistemáticas: o PRESS, histórico, tradução para o português e funcionalidade / Peer review of search strategies for systematic reviews: the PRESS, history, Portuguese translation and functionality / Revisión por pares de las estrategias de búsqueda para revisiones sistemáticas: el PRESS, historia, traducción al portugués y funcionalidad

O Peer Review of Electronic Search Strategies (PRESS) é um instrumento elaborado na Canadian Agency for Drugs & Technologies in Health (CADTH) para avaliar cada elemento das estratégias de busca em bases de dados eletrônicas que podem influenciar a base das evidências das revisões sistemáticas. Os autores obtiveram licença para traduzir o PRESS para o português. O objetivo é contribuir para disseminação, uso e posterior implementação do PRESS, especialmente entre os bibliotecários, consolidando uma prática de avaliação de estratégias de busca das revisões sistemáticas. A metodologia foi o relato de experiência. Para contextualizar, inicia-se com o histórico da construção do PRESS, seguido do processo da tradução e apresentação das funcionalidades de cada tabela. O resultado é a disponibilização da versão do PRESS em português na página da CADTH. Conclui-se que a tradução deve impactar positivamente na qualidade das estratégias de busca das revisões sistemáticas com participação de bibliotecários brasileiros

The Peer Review of Electronic Search Strategies (PRESS) is an instrument developed at the Canadian Agen-cy for Drugs & Technologies in Health (CADTH) to evaluate each element of search strategies in electronic databases that may influence the evidence base of systematic reviews. The authors obtained a license to translate the PRESS into Portuguese. The objective is to contribute to the dissemination, use and sub-sequent implementation of PRESS, especially among librarians, to consolidate the practice of evaluating search strategies for systematic reviews. The methodology used was the experience report. It begins with the history of the construction of PRESS, followed by the report of the translation process and the function-alities of each table. The result is the availability of the PRESS version in portuguese on the CADTH page. It is concluded that the translation should have a positive impact on the quality of search strategies for systematic reviews involving Brazilian librarians

El Peer Review of Electronic Search Strategies (PRESS) es un instrumento de la Canadian Agency for Drugs & Technologies in Health (CADTH) para evaluar cada elemento de las estrategias de búsqueda en bases de datos electrónicas que pueden influir en la base de evidencia de revisiones sistemáticas. Los autores obtu-vieron permiso para traducir PRESS al portugués. El objetivo es contribuir para difusión, uso e implemen-tación del PRESS, especialmente entre bibliotecarios, para consolidar la práctica de evaluar las estrategias de búsqueda de revisiones sistemáticas. La metodología utilizada fue relato de experiencias. Comienza con la historia de la construcción de PRESS, sigue el relato de la traducción, y de las funcionalidades de cada ta-bla. Como resultado el PRESS en portugués está en el sitio web de CADTH. Se concluye que esta traducción debe tener un impacto positivo en la calidad de las estrategias de búsqueda de revisiones sistemáticas que involucren bibliotecarios brasileños

DIGITAL SEARCH ADVERTISING – THE ROLE OF POST-CLICK FACTORS IN GENERATING PURCHASE CONVERSIONS

A lot of research is available on the effectiveness of search as an advertising channel. Most of these studies tend to treat a click on a search ad as a binary event. All of them study the events leading to the click. This paper goes beyond this to study the post click actions taken by a user subsequent to clicking on a search ad, and refers to those actions as depth of interaction, and testing the variables that have an effect on the nal outcome. We use a prescriptive research design employing binary logistic regression analysis. Results indicate that the duration of time spent, device used, and recency of visit have a very high positive effect on the nal outcome.

Metasearchers in the biomedical field An update / Metabuscadores en el área biomédica Una actualización

Abstract The biomedical field has benefited greatly from the influx of information and communication technologies. Over the last few years, enormous strides have been made in organizing, structuring and seeking information, facilitating this task, as evidenced by the various databases and search engines. In this context, metasearchers are a powerful tool for optimizing the effectiveness of searches for scientific evidence and, therefore, represent an added value both in clinical practice as well as in the research setting. This article is aimed at healthcare workers. The purpose is to update the basic concepts about metasearchers, their generalities and the main characteristics of the most outstanding ones in the biomedical field. (Acta Med Colomb 2022; 48. DOI:https://doi.org/10.36104/amc.2023.2587).

Resumen El área biomédica ha recibido grandes beneficios con el influjo de las tecnologías de la información y la comunicación. En los últimos años, en lo que respecta a organizar, estructurar y buscar información, se han visto enormes avances que facilitan esta labor y las diversas bases de datos y los motores de búsqueda dan cuenta de ello. En este contexto, los metabuscadores constituyen una herramienta poderosa para optimizar la eficacia de las búsquedas de evidencia científica y, por ende, representan un valor agregado tanto en la práctica clínica como en el escenario de la investigación. Este artículo está dirigido al personal de la salud. El propósito es actualizar conceptos básicos en cuanto a los metabuscadores, sus generalidades y las principales características de los más destacados en el área biomédica. (Acta Med Colomb 2022; 48. DOI:https://doi.org/10.36104/amc.2023.2587).

Perspectives of Teachers at Medical Colleges Across India regarding the Competency based Medical Education Curriculum – A Qualitative, Manual, Theoretical Thematic Content Analysis

Background: Competency-based medical education (CBME) curriculum has been implemented in India since 2019 with a goal to create an “Indian Medical Graduate” (IMG) possessing requisite knowledge, skills, attitudes, values, and responsiveness. Objectives: To explore teachers’ perceptions across India at medical colleges on the newly implemented competency-based medical education curriculum. Methods: This was a qualitative cross?sectional study conducted among teachers working at medical colleges across India, between February and April 2022 (n = 192). The data collection was done using Google forms online survey platform on teachers’ perception regarding CBME, its specific components, and perceived bottlenecks. We analyzed this qualitative data using manual, theoretical thematic content analysis following the steps endorsed in Braun and Clarke’s six-phase framework. Results: The majority of the teachers (64.1%) have positively responded to the CBME curriculum’s implementation. However, it came with a caution that the curriculum should continuously evolve and adapt to regional demands. The foundation course, early clinical exposure, and the family adoption program were the specific components of CBME curriculum over which the teachers raised concerns. The need for additional teachers in each department (department-specific teacher or faculty per hundred students ratio to be worked out) and the need for enabling faculty preparedness through adequate training was highlighted. Concerns were also raised regarding implementing CBME with teachers without a medical background (especially in preclinical departments). Conclusion: It is the need of the hour for the curriculum to incorporate a systematic feedback mechanism built into the system, though which such critical appraisals can be meaning collated and acted upon, to ultimately evolve, thereby creating an “Indian Medical Graduate” for the needs of todays’ society.

Relevância das fontes de informação no cenário brasileiro durante a pandemia de covid-19 / Relevance of the information sources in the Brazilian scenario during the covid-19 pandemic / Relevancia de las fuentes de información en el escenario brasileño durante la pandemia del covid-19

Este artigo apresenta os resultados de um estudo sobre a percepção que os usuários têm da relevância das fontes de informação utilizadas por eles para se elucidarem sobre a covid-19 no cenário brasileiro durante a pandemia dessa doença. Os dados coletados para o estudo foram obtidos mediante a aplicação de um questionário distribuído via e-mail, Facebook, Instagram e WhatsApp. Os resultados mostram atribuição de relevância predominante a fontes formais e institucionais, como a Organização Mundial de Saúde (OMS), artigos científicos, universidades, Agência Nacional de Vigilância Sanitária (Anvisa), hospitais e postos de saúde. Dentre as fontes consideradas menos relevantes destacam-se jornais e/ou revistas, o Ministério da Saúde (MS) brasileiro e canais de televisão. As redes sociais (Facebook, Instagram, YouTube, WhatsApp, Twitter etc.), os amigos e/ou colegas, os mecanismos de busca na Internet (Google, Yahoo, Bing etc.) e familiares também se destacam como fontes de informação menos relevantes

This paper presents the results of a study on the users' perception of information of the relevance of infor-mation sources used by them to elucidate about covid-19 in the Brazilian scenario during the pandemic of this disease. The data were collected with use of a questionnaire distributed by email, Facebook, Instagram and WhatsApp. The results demonstrated a predominant attribution of relevance to formal and institution-al information sources, such as the World Health Organization (WHO), scientific papers, universities, the Anvisa ­ Agência Nacional de Vigilância Sanitária (the National Health Surveillance Agency), hospitals, and health centers. Among the sources considered less relevant were highlighted newspapers and/or mag-azines, the Brazilian Ministry of Health, and television channels. Social networks (Facebook, Instagram, YouTube, WhatsApp, Twitter, etc.), friends and/or colleagues, Internet search engines (Google, Yahoo, Bing, etc.) and family members also stand out as less relevant sources of information

Este artículo presenta los resultados de un estudio sobre la percepción que tienen los usuarios de la relevancia de las fuentes de información utilizadas por ellos para enterarse de la covid-19 en el escenario brasileño durante la pandemia de esta enfermedad. Los datos recolectados para el estudio se obtuvieron mediante la aplicación de una encuesta distribuida a través de correo electrónico, Facebook, Instagram y WhatsApp. Los resultados muestran una atribución de relevancia predominante a fuentes formales e institucionales, como la Organización Mundial de la Salud (OMS), artículos científicos, universidades, la Anvisa - Agência Nacional de Vigilância Sanitária (Agencia Nacional de Vigilancia Sanitaria), hospitales y centros de salud. Entre las fuentes consideradas menos relevantes están periódicos y/o revistas, el Ministerio de Salud brasileño y canales de televisión. También se destacan como fuentes de información menos relevantes las redes sociales (Facebook, Instagram, YouTube, WhatsApp, Twitter, etc.), los amigos y/o compañeros, los motores de búsqueda en la Internet (Google, Yahoo, Bing, etc.) y los familiares.

Study on the mechanism of the effect of endothelial progenitor cell injury-derived microparticles on endothelial progenitor cells / 重庆医学

Objective To investigate the effects of endothelial progenitor cells(EPC)-derived microp-articles(MPs)with different injury treatments on EPC.Methods EPC cells were cultured and EPCs were i-dentified by flow cytometry.EPCs were treated with high glucose(HG)and tumor necrosis factor(TNF)-a recombinant protein,and MPs were extracted.The structural changes of microtubules,Golgi bodies and other organelles in EPC were observed by transmission electron microscopy.MTT assay was used to detect cell pro-liferation.Cell scratch assay was used to evaluate cell migration ability.Cell lumen formation assay was used to detect lumen formation.The expression levels of endothelial nitric oxide synthase(eNOS),silent informa-tion regulator 1(SIRT1),rat sarcoma(RAS)and extracellular regulated protein kinase(ERK)in EPC after different treatments were detected by quantitative real-time fluorescence PCR(qPCR)and Western blot.Re-sults Compared with the control-EPC-MPs group,the microtubule structure of the HG-EPC-MPs group and the TNF-α-EPC-MPs group was complete,the length was shortened,and the Golgi structure was relatively complete.Compared with the control-EPC-MPs group,the proliferation rate of EPC in the HG-EPC-MPs group and the TNF-α-EPC-MPs group was down-regulated,the cell migration ability was decreased,and the tube formation was decreased(P＜0.05).Compared with the control-EPC-MPs group,the mRNA and protein expressions of eNOS,SIRT1,RAS and ERK in the HG-EPC-MPs group and the TNF-α-EPC-MPs group were down-regula-ted(P＜0.05).Conclusion HG and TNF-α mediated MPs derived from EPC injury may change the structure of organelles in EPC by regulating the expression of SIRT1/ERK1 pathway proteins,thus affecting the biolog-ical function of EPC.

Design of remote fault detection method for CT scanning equipment based on two-dimensional search model and ZigBee network / 中国医学装备

Objective:To design and construct a remote fault detection method for CT scanning equipment based on two-dimensional search model and ZigBee network to improve the accuracy of fault detection.Methods:ZigBee network technology was used to collect the operating status data of CT scanning equipment from three aspects:environmental factors,electrical factors and gas circuit factors.The time and frequency domain signals were extracted from the monitoring data,and the extracted fault signal feature parameters were fused.The fault data were transformed into stationary time series by inverse binary transformation to restrain the fluctuation of the data.The dependence degree of fault data was calculated by establishing corresponding two-dimensional search model and matching function.Based on this,Bayesian evaluation function was introduced to realize the remote detection of equipment fault.A large-scale clinical CT scanner in clinical use in the hospital was selected as the experimental prototype,and at the same time,550 real fault data generated from the 80 CT scanning scanners with the same model and configuration as the experimental prototype were randomly selected as training samples.The accuracy of CT scanning equipment faults remote detection method with that of the long short-term memory network(referred to as method 1)and deep belief network(referred to as method 2)were compared.Results:The designed remote fault detection method of CT scanning equipment only had detection error on status label 5,but the judgment error was in the controllable range.In the five fault detection experiments,the detection accuracy of the remote fault detection method of CT scanning equipment was more than 80%,which was much higher than that of method 1 and method 2.Conclusion:The fault detection method of CT scanning equipment has a high detection accuracy and can realize the practical requirement of remote detection of CT scanning equipment.

Analysis and suggestions on China′s Traditional Chinese Medicine health service policies from the perspective of policy life cycle / 中华医院管理杂志

Objective:To analyse China′s Traditional Chinese Medicine(TCM) health service policy from the perspective of policy life cycle, so as to provide reference for improving the policy system of TCM health service.Methods:The official websites of national government agencies were searched for policy documents on TCM health service from 2012 to 2022, using the keywords of " Chinese medicine" " Traditional Chinese Medicine" and " health service", and policy text entries were extracted and coded. A two-dimensional analytical framework of policy tools(supply, demand, and environment) and policy life cycle(agenda setting, policy formulation, policy implementation, and policy evaluation) was constructed to quantitatively analyze the policy texts.Results:A total of 58 policy documents were included, containing 2 898 text entries. The distribution of policy instruments was uneven, with a high percentage of entries using supply-based instruments(40.57%, 1 176 entries), followed by environmental instruments(38.86%, 1 126 entries) and demand-based instruments(20.57%, 596 entries). From the perspective of policy cycle, the policy tools were mainly concentrated in the stages of policy formulation(53.77%, 1 558 entries) and policy implementation(36.86%, 1 068 entries), while the policy tools in the stages of agenda setting(4.97%, 144 entries) and policy evaluation(4.40%, 128 entries) needed to be strengthened.Conclusions:In recent years, the distribution of policy tools in China′s TCM health service policy was uneven, and the articulation of the stages in the policy life cycle needed to be strengthened.

Development status of UAV and its application in aviation emergency rescue / 医疗卫生装备

The present situation of UAV in the world was introduced,and its application was described in disaster relief,medical rescue and aerial search and rescue.The problems and challenges of UAV were analyzed in terms of safety and tech-nology.The future research directions of UAV were proposed for aviation emergency rescue.[Chinese Medical Equipment Journal,2023,44(10):108-113]

Formulation,Interpretation and Application of the Group Standard of"Specification for Scientific and Technical Novelty Search of Traditional Chinese Medicine" / 医学信息学杂志

Purpose/Significance To strengthen the management of scientific and technical novelty search of traditional Chinese med-icine(TCM),and to standardize the work of novelty search.Method/Process The process of"Specification for Scientific and Technical Novelty Search of Traditional Chinese Medicine"standard formulation is expounded in detail,and the key points of the standard and its application in science and technology novelty management system are analyzed.Result/Conclusion The standard can better guide the scientific and technical novelty search institutions,standardize the writing of scientific and technical novelty search reports,improve the quality of scientific and technical novelty search reports,and help promote the healthy development of scientific and technical novelty search of TCM.The scientific and technical novelty management system based on the standard improves the efficiency of novelty search.

Por uma pesquisa e escrita parafusos: pulos, rodopios e invenções de si / For research and writing screws: jumps, twirls and inventions of self / Para tornillos de investigación y escritura: saltos, giros e autoinvenciones

O artigo parte da aposta na pesquisa como uma prática em movimento, na composição de territórios do ato de pesquisar como uma experiência. Inspiradas(os) na força disruptiva do torcer-retorcer dos Parafusos (folguedo sergipano, derivado de práticas de resistência à escravidão dos povos pretos), propomos um método-pensamento de inventar modos de ver, dizer e narrar a partir daquilo que está ao nosso redor, uma posição em relação ao mundo e a si mesmo, engendrando a ideia de que este mundo não é um dado, mas um efeito de nossas práticas. A partir dessa perspectiva, intentamos interpelar as próprias práticas discursivas e não discursivas da Psicologia, em favor de abrir trilhas nas quais esse saber possa refundar sua própria história, acentuando suas descontinuidades e heterogeneidades e, com isso, uma atitude de fazer frente às tendências colonialistas, agora em suas versões neoliberais. Esse modo de pesquisar se faz por: operar uma ideia-método genealógico-cartográfica e uma escrita polifônica; produzir máquinas de guerras nômades, minoritárias, pós-identitárias, decoloniais; e inventar com aquilo que está ao nosso redor em favor de saberes e fazeres das redes locais, que, tais como a planta mangabeira, não se deixam domesticar.(AU)

The article starts from the research as a moving practice; in the composition of territories of the act of researching as an experience. Inspired by the disruptive force of the twisting-twining of the Screws (revelry from Sergipe, derived from practices of resistance to the slavery of black people), we propose a thought-method of inventing ways of seeing, saying, and narrating from what is around us, a position in relation to the world and itself, engendering the idea that this world is not a given, but an effect of our practices. From this perspective, we try to question the very discursive and non-discursive practices of Psychology, in favor of opening trails, in which this knowledge can refund its own history, accentuating its discontinuities and heterogeneities and, thus, an attitude of facing the colonialist tendencies, now in their neoliberal versions. This way of searching is done by: operating a genealogical-cartographic idea-method and polyphonic writing; producing nomadic, minority, post-identity, decolonial war machines; and inventing with what is around us, in favor of knowledge and practices of local networks, which, like the mangabeira plant, do not allow domestication.(AU)

Este artículo parte de la investigación como práctica en movimiento, en la composición de territorios del acto de investigar como experiencia. Inspirándonos en la fuerza disruptiva de torsión-retorsión de los Tornillos (juerga de Sergipe, derivada de prácticas de resistencia a la esclavitud de los negros), proponemos un método de pensamiento para inventar formas de ver, decir y narrar a partir de lo que nos rodea, una posición en relación con el mundo y con él mismo, el cual constituye la idea de que este mundo no es un hecho, sino un efecto de nuestras prácticas. Desde esta perspectiva, pretendemos cuestionar las prácticas discursivas y no discursivas de la Psicología en favor de abrir caminos, en las cuales este conocimiento pueda refundar su propia historia, acentuando sus discontinuidades y heterogeneidades y, así, una actitud de hacer ante las prácticas colonialistas, ahora desde una perspectiva neoliberal. Este modo de investigación se realiza mediante: el funcionamiento de un método-idea de escritura genealógica, cartográfica y polifónica; la producción de máquinas de guerra nómadas, minoritarias y posidentitarias; y la composición con el tema que nos rodea a favor del conocimiento y las redes locales que no puede ser domesticada, como el árbol mangabeira.(AU)

An U pdate on B iomedical L iterature Search for B udding R esearch S cholars

Literature search can be defined as systematic review of all scientific resources, both published and unpublished. Literature search is continuous process. It provides new ideas of research. It helps us to frame new research questions and to identify the knowledge gap. There are no straightforward rules for literature search. Each researcher has its own m ethod of literature search. In this review article we shall discuss about various types and sources of literature, steps and techniques of literature search which will serve as a quick guide for budding research scholars.

Sustentabilidade afetiva na universidade: por uma política de resistência / Affective sustainability at the university: for a policy of resistance / Sostenibilidad afectiva en la universidad: para una policia de resistencia

Vivemos em um tempo histórico marcado pela exigência crescente de produção de conhecimento científico. Os protagonistas desse empreendimento são os Programas de Pós-graduação que se dedicam à produção científica e à formação de pesquisadores-professores comprometidos com a transformação social e com a democratização do conhecimento. O presente estudo busca problematizar as condições objetivas e subjetivas dessa produção, enfatizando a necessidade de favorecer uma sustentabilidade afetiva no contexto acadêmico. Para tanto, a pesquisa foi dividida em três momentos. Primeiro, é exposto um breve histórico da Psicologia como ciência. Em seguida, abordamos a possibilidade de construir uma sustentabilidade afetiva nas universidades. Por fim, apresentamos a desobediência como estratégia de resistência ao produtivismo vazio das ciências. Como conclusão, o estudo mostra que as pesquisas, para além de seus resultados objetivos, envolve também a experimentação de múltiplos afetos que são a condição de possibilidade para alavancar transformações sociais e políticas em nosso país.

We live in a historical period marked by the growing demand for the production of scientific knowledge. The protagonists of this enterprise are the Graduate Programs that are dedicated to scientific production and the training of researchers-professors committed to social transformation and the democratization of knowledge. The present study aims to problematize the objective and subjective conditions of this production, emphasizing the need to favor an affective sustainability in the academic context. Therefore, the research was divided into three moments. First, a brief history of Psychology as science is exposed. Next, we address the possibility of building affective sustainability in universities. Finally, we present disobedience as a strategy of resistance to the empty productivism of science. In conclusion, the study shows that research, in addition to its objective results, also involves the experimentation of multiple affects that are the condition of possibility to leverage social and political transformations in our country.

Vivimos en un tiempo histórico marcado por la creciente demanda de producción de conocimiento científico. Los protagonistas de esta empresa son los Programas de Posgrado dedicados a la producción científica y la formación de investigadores-profesores comprome tidos con la transformación social y la democratización del conocimiento. El presente estudio busca problematizar las condiciones objetivas y subjetivas de esta producción, destacando la necesidad de favorecer la sostenibilidad afectiva en el contexto académico. Por lo tanto, la investigación se dividió en tres momentos. Primero, una breve historia de la psicología a medida que se expone la ciencia. A continuación, abordamos la posibilidad de construir sostenibilidad afectiva en las universidades. Por último, presentamos la desobediencia como una estrategia de resistencia al productivismo vacío de las ciencias. En conclusión, el estudio muestra que la investigación, además de sus resultados objetivos, también implica la experimentación de múltiples afectos que son la condición de posibilidad de aprovechar las transformaciones sociales y políticas en nuestro país.