RESUMO
Objective To compare the sedative effect of intranasal dexmedetomidine and midazo-lam for premedication in children,and the effect of reducing agitation after general anesthesia.Methods Sixty pediatric patients,age 3~7, ASA I~II,were randomly allocated into 3 groups(DEX1,DEX2,MID) with 20 cases for each group.The children received intranasal dexmedetomidine 1.0μg/kg ( group DEX1) , dexmedetomidine 2.0μg/kg (group DEX2),midazolam 0.2 mg/kg(group MID) 30min before induction re-spectively.The sedation status, behavior scores, emergence agitation and other complications after surgery were observed.Results Children in group DEX2 were significantly more sedated after general anesthesia when compared with other groups ( P <0.05).Conclusions The sedative effect of intranasal dexmedeto-midine is satisfying for premedication in children.And the effect of reducing agitation after general anesthe-sia is superior to that of midazolam.