Effects of preoperative dezocine patient-controlled analgesia pump on stress response and cognitive function in elderly patients with lower extremity fractures / 中国临床药理学与治疗学

AIM: To explore the effects of preoperative application of dezocine patient-controlled analgesia pump on stress response and cognitive function in elderly patients with lower extremity fractures. METHODS: A total of 80 elderly patients with lower extremity fractures who were treated from November 2018 to June 2020 were selected and randomly divided into a control group and a study group, 40 cases in each. The control group was not given a patient-controlled analgesia pump before anesthesia, and the study group was given intravenous analgesia with a dezocine patient-controlled analgesia pump before surgery. The postoperative stress response, cognitive function and safety were compared between the two groups.RESULTS: There were no significant differences in cognitive function MMSE score, stress response index (cortisol, epinephrine) levels, and inflammatory factors (IL-6, TNF-α) levels between the two groups before intervention (P>0.05). Compared with the indexes after operation, the MMSE scores of the study group at 12 h, 24 h and 3 days after operation were higher than those in the control group (P<0.05); The levels of cortisol, epinephrine, IL-6 and TNF-α in the study group were lower than those in the control group at 12 h and 24 h after operation (P<0.05); At the same time, the incidences of respiratory depression, urinary retention and nausea and vomiting in the study group were significantly lower than those in the control group (P<0.05).CONCLUSION: Preoperative application of dezocine patient-controlled analgesia pump in elderly patients with lower extremity fracture can significantly reduce postoperative stress response, reduce inflammatory response, and improve postoperative cognitive function, which is worthy of clinical application.

A self-controlled study on corneal nerve invasion phenomenon of Bowman's membrane in patients with ⅢA lattice corneal dystrophy / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To analyze and study the corneal nerve invasion phenomenon of Bowman's membrane in patients with IIIA lattice corneal dystrophy by confocal laser scanning microscopy. Quantitative analysis of 10a continuous observation image data was performed, followed by self-control studies.<p>METHODS: A total of 10 patients(13 eyes)with IIIA Lattice corneal dystrophy were continuously examined by confocal laser scanning microscopy. The data were observed and analyzed. <p>RESULTS: The normal corneal nerve of Bowman's membrane(Grade 0)of IIIA LCD patients gradually decreased with the prolongation of observation time. The nerves of grade I to V involved(amyloid-wrapped nerve fibers)gradually increased correspondingly. So suggested that the corneal nerve invasion of Bowman's membrane(amyloid deposits)in patients with IIIA LCD were gradually increasing with time. <p>CONCLUSION: In patients with type ⅢA lattice corneal dystrophy, there is a neurotropic phenomenon in Bowman's membrane, which gradually worsens with the aggravation of the lesion. This lesion can explain the recurrent epithelial damage of the IIIA LCD from some degrees. Continuous observation of patients with type IIIA LCD by corneal laser confocal microscopy can well understand the development of the lesion and explain its clinical manifestations.

Vigilancia activa de convulsiones febriles vinculadas a vacuna pentavalente en un hospital centinela en Uruguay / Active surveillance of febrile seizures associated to DPT vaccines in a sentinel hospital in Uruguay

Resumen Introducción: Las convulsiones febriles son eventos supuestamente atribuidos a la vacunación e inmunización (ESAVI) frecuentemente asociados a vacuna difteria - tétanos- pertussis a células completas. Objetivo: Analizar la asociación de convulsiones febriles con la administración de la vacuna pentavalente en niños bajo 2 años de edad asistidos en el Centro Hospitalario Pereira Rossell durante el año 2014. Material y Métodos: Estudio de series de casos auto-controlados. Se incluyeron niños procedentes de Montevideo con 2 a 24 meses de edad con diagnóstico de convulsión febril. Se estimó el riesgo relativo (RR) de los períodos de riesgo (0 a 3 días) y de lavado (4a 14 días), en comparación con el período de no riesgo (más de 14 días). Resultados: Se registraron 135 convulsiones febriles, que ocurrieron en 114 niños; 16 niños presentaron dos o más episodios. El total de eventos ocurridos en el período de riesgo fueron 7 (5,2%) y 8 (5,9%) en el período de lavado. El período de riesgo mostró un RR significativo de 4,14 (IC 95%: 1,73; 8,36). Conclusiones: Este trabajo permitió establecer una línea de base nacional sobre el riesgo de convulsiones febriles asociadas con la vacunación pentavalente al utilizar por primera vez en el país una metodología específica para tal fin.

Background: Febrile seizures are VAERS often associated with whole-cells Diphtheria-Pertussis-Tetanus vaccines. Aim: To analyze the association of febrile seizures with the administration of pentavalent vaccine in children under two-years-old assisted in the Centro Hospitalario Pereira Rossell (CHPR), in Montevideo during 2014. Methods: Self-controlled case series study. We included children from Montevideo from two to 24-month-old at the time of admission, with diagnosis of febrile seizure at the time of discharge. We estimated the relative risk in three time periods: 0 to 3 days (risk period), 4 to 14 days (wash-out) and more than 14 days after vaccination (no-risk). Results: We recorded 135 febrile seizures in 114 children, 16 of whom presented two or more events. The total number of events was 7 (5.2%) in risk periods and 8 (5.9%) in wash-out periods. The risk period showed a significantly increased risk (RR = 4.14, CI 95% = [1.73; 8.36]). Conclusions: This work allowed us to establish a national base line for the risk of febrile seizures associated with pentavalent vaccination, by using for the first time in the country a methodology specifically designed for this goal.

Effect of self controlled exercise program on cancer-related fatigue and sleep quality in cancer patients / 中国实用护理杂志

Objective@#To explore the effect of self controlled exercise program on cancer-related fatigue and sleep quality in patients with cancer chemotherapy.@*Methods@#A total of 195 cases of cancer chemotherapy patients in Harbin Medical University Cancer Hospital were selected by convenience sampling. They were divided into experimental group (97 cases) and control group (98 cases) by random digits table method. The patients in the control group were treated with routine nursing, and the patients in the experimental group implemented the self-control exercise program on the basis of routine nursing. After 12 weeks, the Cancer Fatigue Scale and the Pittsburgh Sleep Quality Index were evaluated.@*Results@#The total score of cancer induced fatigue was (37.67 ± 8.35) points in the experimental group and (42.42±8.94) points in the control group. The difference was statistically significant (t = 3.833, P < 0.05). The total score of sleep quality was (9.73±2.69) points in the experimental group and (11.92±3.05) points in the control group. The difference was statistically significant (t = 5.316, P < 0.05).@*Conclusions@#The self-control exercise program can improve the cancer induced fatigue and sleep quality of cancer patients. It is suggested that the application of self-control exercise in the nursing of cancer patients should be strengthened in the future.

Effect of seLf controLLed exercise program on cancer-reLated fatigue and sLeep quaLity in cancer patients / 中国实用护理杂志

Objective To explore the effect of self controlled exercise program on cancer-related fatigue and sleep quality in patients with cancer chemotherapy. Methods A total of 195 cases of cancer chemotherapy patients in Harbin Medical University Cancer Hospital were selected by convenience sampling. They were divided into experimental group (97 cases) and control group (98 cases) by random digits table method. The patients in the control group were treated with routine nursing, and the patients in the experimental group implemented the self-control exercise program on the basis of routine nursing. After 12 weeks, the Cancer Fatigue Scale and the Pittsburgh Sleep Quality Index were evaluated. ResuLts The total score of cancer induced fatigue was (37.67 ± 8.35) points in the experimental group and (42.42±8.94) points in the control group. The difference was statistically significant (t = 3.833, P <0.05). The total score of sleep quality was (9.73 ± 2.69) points in the experimental group and (11.92 ± 3.05) points in the control group. The difference was statistically significant (t = 5.316, P < 0.05). ConcLusions The self-control exercise program can improve the cancer induced fatigue and sleep quality of cancer patients. It is suggested that the application of self-control exercise in the nursing of cancer patients should be strengthened in the future.

Effect and function analysis of sulfentanyl on tongue cancer in patients with postoperative analgesia / 中国生化药物杂志

Objective To investigate the effect and function analysis by sulfentanyl in patients with tongue cancer postoperative analgesia.Methods A total of 74 patients with radical resection of tongue cancer in department of anesthesiology with general anesthesia from our hospital were collected, patients or their families signed consent, according to postoperative self-controlled intravenous analgesia drugs divided into experimental group and control group with 37 cases in each group.Patients in control group were treated by fentanyl self-controlled intravenous analgesia;patients in experimental group were treated by sulfentanyl self-controlled intravenous analgesia, determination of the analgesic effect, sedative effect and the changed of vital signs postoperative 2, 4, 8, 12, 24, 48 h,at the same time recorded complications.Results After operation, at different time points analgesic effect and sedative effect were changed in the two groups, the VAS scored of the experimental group was lower than the control group postoperative 2, 4, 8, 12, 24, 48 h time points, the Ramsay Sedation scored of the experimental group was lower than the control group postoperative 2 h, 4 h, 8 h, 12 h time points ( P 0.05 ) . Conclusion Sulfentanyl in the treatment of patients with radical resection of tongue cancer the analgesic effect and sedative effect are better than fentanyl, has no effect on the vital signs, and the role is security and exact.

The effect acute pain service for the postoperative continue analgesia after cesarean section / 中国基层医药

Objective To observe the acute pain service for analgesia effect and complications of postopera-tive analgesia and satisfaction after cesarean section.Methods 360 patients undergoing cesarean section and postop-erative continue analgesia were randomly divided into two groups.The control group (group C,n =178)was given with routine postoperative self -control analgesia give guidance.In the observation group (group A,n =182),a group for acute pain was founded,and the patients were explained about PCA self -control analgesia related knowledge before operation,together with the APS analgesia group people,the patients were given with postoperative pain management,observed self -control analgesia efficacy and side effects,and gives the corresponding treatment and guidance.The difference of analgesia incomplete and complication were observed such as nausea and vomiting,calm, itchy skin.Questionnaires that postoperative analgesia satisfaction survey were filled inafter discharged.The satisfac-tion of nurse with the APS were observed.Results Postoperative analgesia complication in group A were significantly lower than that in group C(P <0.01,P <0.05),APS analgesic incomplete in group C was significantly higher than groupA (χ2 =11,P <0.01).The satisfaction of PCA in group A were significantly higher than group C (P <0.01, P <0.05),ward nurses job satisfaction also increased significantly (t =2.63,P <0.05).Conclusion Acute pain service effectively improve analgesic quality and reduce related complications after cesarean section increase patients postoperative analgesia satisfaction,increase the ward nurses job satisfaction.

Efeitos do autocontrole da sequência de movimentos na aprendizagem de uma tarefa de "timing" coincidente / Effects of self-controlling the movement sequence on learning a coincident timing task

O objetivo do presente estudo foi investigar os efeitos de autocontrolar a sequência de movimentos, na aprendizagem de uma tarefa de "timing" coincidente. Trinta adultos jovens (idade = 23 ± 5,5 anos) sem experiência prévia na tarefa foram distribuídos aleatoriamente em dois grupos com condições diferentes quanto a sequência de movimentos, autocontrolado (LIVRE) e externamente controlado (DET). Os participantes deveriam tocar seis sensores sequencialmente, o último coincidentemente à chegada de um estímulo visual (tarefa de "timing"). Na aquisição, os participantes do grupo DET deveriam tocar os sensores numa sequência determinada, enquanto os do grupo LIVRE poderiam tocar os sensores em qualquer ordem (exceto o último, que foi o mesmo para ambos os grupos). Apesar de nenhuma diferença ter sido encontrada em relação ao número de tentativas necessárias ao alcance do desempenho critério na aquisição, o grupo LIVRE apresentou pior desempenho na transferência comparado ao grupo DET, indicando que ter controle sobre a sequência de movimentos que precede a coincidência prejudica a aprendizagem da habilidade

The purpose of this study was to investigate the effects of self-controlling a movement sequence on learning a coincident timing task. Thirty young adults (age = 23± 5.5 years) with no previous experience with the task were randomly assigned into two groups with different movement sequence conditions, self-controlled (FREE) and externally controlled (DET). Participants were required to tap six sensors sequentially, the last one coinciding with the arrival of a visual stimulus (timing task). On acquisition, participants in the DET group had to tap the sensors in a determined sequence, while those in the FREE group were allowed to tap the sensors in any order (except for the last one, which was the same for both groups). While no difference was found regarding the number of trials needed to reach the performance criterion in acquisition, the group FREE showed higher timing errors in transfer compared to the group DET, indicating that self-controlling the movement sequence that precedes the coincidence impairs the learning of the motor skill

Efeitos do "feedback" autocontrolado na aprendizagem do lançamento da bola da ginástica rítmica / Effects of self-controlled feedback on the learning of ball throwing in rhythmic gymnastics

O objetivo do presente estudo foi investigar os efeitos da frequência autocontrolada de "feedback" na aprendizagem do lançamento da bola da ginástica rítmica. A amostra foi constituída de 24 crianças, de sete a 10 anos de idade, distribuídas em dois grupos em relação aos diferentes tipos de condições de "feedback": autocontrolado e externamente controlado. O estudo foi composto de uma fase de prática e um teste de retenção. Os resultados de um questionário revelaram que a maioria dos participantes do grupo autocontrolado solicitou "feedback" principalmente após as boas tentativas de prática, enquanto os participantes do grupo "yoked" indicaram ter recebido "feedback" nas tentativas em que o desejavam. Nenhuma diferença foi encontrada em relação ao desempenho ou aprendizagem. Conclui-se que a frequência autocontrolada de "feedback" é tão eficiente quanto a frequência externamente controlada na aprendizagem da habilidade motora específica lançamento do aparelho bola em crianças desta faixa etária...

The aim of this study was to investigate the effects of self-controlled frequency of feedback on the learning of ball throwing in rhythmic gymnastics. 24 children, ranging from 7 to 10-years old participated in the study, divided into two groups in relation to the different feedback conditions: self-controlled and externally controlled (yoked). The study consisted of a practice phase and a retention test. The results of a questionnaire showed that the majority of participants of the self-control group requested feedback mainly after good trials, while participants of the yoked group indicated that they had received feedback on the trials they desired. No differences were found regarding performance or learning. We concluded that self-controlled feedback frequencies are as effective as externally controlled feedback frequencies for the learning of rhythmic gymnastics ball throwing in children...

Efeitos do conhecimento de resultados autocontrolado na aprendizagem motora / Effects of self-controlled knowledge of results in motor learning

O objetivo do presente estudo foi analisar três diferentes estratégias de fornecer conhecimento de resultados (CR): autocontrolado, yoked pareado por tentativa e yoked pareado pela frequência média total de CR, na prática aleatória. A amostra foi constituída por 45 voluntários universitários, distribuídos em três grupos (n= 15 sujeitos). A tarefa consistiu em pressionar as teclas 2, 4, 8 e 6 do teclado numérico de um computador, em três diferentes tempos alvo (700, 900 e 1100 ms), praticados aleatoriamente. O experimento constou de fase de aquisição e testes de retenção e transferência atrasados. A análise dos dados foi realizada por meio da ANOVA e não foi constatada diferença significativa entre os grupos. Os resultados demonstraram que não houve efeito das frequências autocontroladas para a aprendizagem motora quando se utiliza a prática aleatória. Além disso, uma nova possibilidade de parear o grupo autocontrolado foi apresentada.

The purpose of this study was to examine three different strategies to provide knowledge of results (KR), yoked paired by trial and yoked paired by average of total frequency of KR in random practice. The sample was composed by 45 volunteers, distributed into three groups (n=15 subjects). The task consisted of press three keys, 2, 4, 8 and 6 in the numeric keypad of the computer in three different total time (700, 900 and 1100 ms) in random practice. The experiment consisted of acquisition phase and delay retention and transfer test. The data analysis was conducted by ANOVA and the results were not demonstrated difference between groups. The results showed no effect of self-controlled frequency of KR to the motor learning when using random practice. In addition, a new possibility to be used the yoked group was presented.

The impact of startup time of patient controlled intravenous analgesia on the analgesia efficacy in aged patients after thoracotomy / 中华护理杂志

Objectives To explore the optimal startup time of patient controlled intravenous analgesia (PCIA) in aged patients after thoracotomy for pulmonary lobectomy.Methods The 67 aged patients after thoracotomy for pulmonary lobectomy from January to December 2008 were randomized divided into two groups:PCIA was startup immediately after waking (instantly group) or after removal tracheal intubation (delayed group).The analgesia efficacy,cardiopulmonary function and side effect were evaluated at the awake time,12,24 and 48 hours after surgery respectively.Result Both of VAS scores at 12 hours after surgery and oxygenation index at 48 hours after surgery had significant difference (P<0.05) between the two groups.The analgesia efficacy was better in the instantly group.There was no significant difference on the duration of mechanical ventilation and side-effect rates between the two groups.No patient suffered from respiratory depression.Conclusion The early use of PCIA in aged patients after thoracotomy for pulmonary lobectomy can gain better pain control and oxygenation effect.

Changes of Alpha Competitive Structure after Administration of Single Dose Methylphenidate in Children with Attention Deficit Hyperactivity Disorder / 中国心理卫生杂志

Objective:To investigate the effects of stimulant medications on the EEG of children with attention deficit hyperactivity disorder(ADHD) by measuring the changes of the alpha competitive structure after administration of single dose of methylphenidate,and to explore the neuropathological mechanism of ADHD.Methods:The study involved 110 ADHD children who met the DSM-Ⅳ diagnostic criteria of ADHD and 110 normal children matched by age and sex.Their continuous EEG data were collected before and 2 hours after taking methylphenidate(10 mg) and were analyzed with EEG-encephaloflutuographic technology(EEG-ET).Results:(1)After taking methylphenidate,the main frequency of alpha band obviously increased [(8.97?0.94) Hz vs.(9.40?0.99) Hz,P0.05].Conclusion:Single dose methylphenidate can ameliorate the brain self-organization in ADHD children and improve the lower efficient state,and produce changes in the EEG towards normalization.