The mechanism of NLRP3 inflammasome affecting vascular aging and the development of related drugs / 药学学报

Nucleotide binding oligomerization domain (NOD)-like receptor protein 3, NLRP3) inflammasomes regulate the secretion of caspase-1, interleukin-18 (IL-18), IL-1β, and other cytokines, and participates in aging. In recent years, it has been found that NLRP3 inflammasomes are abnormally activated in aging heart and vessels, and inhibition of NLRP3 inflammasomes can alleviate heart aging and vascular aging. This review summarizes the research of NLRP3 inflammasome in heart and vascular aging, and the related drugs to promote the discovery of the mechanism of NLRP3 inflammasome in heart and vascular aging and the development of related drugs.

Development of senolytics for selectively elimination of senescent cells / 中国药理学通报

Aging is the primary risk factor for many of the most common chronic diseases. The association of cellular senescence with aging-associated conditions has gaining increasing attention. There is now considerable evidence that senescent cell accumulation is an underlying mechanism of aging and age-related diseases. Senescent cells have been emerging as a target for new therapeutic strategies against aging-related pathology. Herein, we review the evidence that cellular senescence drives age-related deterioration and senolytics produce beneficial effect by selective elimination of senescent cells.

Can we rejuvenate? Implications of biological aging research / 영남의대학술지

The life history of man is summarized as a birth-aging-disease-death. Man eventually ages and dies. How long can humans live? What is aging? Why do we age? Is aging inevitable? Can we rejuvenate? Recent researches on biological aging suggest that humans might overcome aging and rejuvenate. In this paper, we review the biologic characteristics of aging and the latest results of biological aging research, implicating that aging can be controlled, further treated, and that humans can ultimately be rejuvenated.

Can we rejuvenate? Implications of biological aging research / 영남의대학술지

The life history of man is summarized as a birth-aging-disease-death. Man eventually ages and dies. How long can humans live? What is aging? Why do we age? Is aging inevitable? Can we rejuvenate? Recent researches on biological aging suggest that humans might overcome aging and rejuvenate. In this paper, we review the biologic characteristics of aging and the latest results of biological aging research, implicating that aging can be controlled, further treated, and that humans can ultimately be rejuvenated.