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Objective:To probe into the mechanism of Shenshuai Capsule in delaying advance of chronic renal failure(CRF)and against interstitial renal fibrosis.Methods:74 cases of CRF at decompensation phase were randomly divided into a treatment group and a control group.Changes of their serum urea nitrogen(BUN),creatinie(SCr),endogenous creatinine clearance rate(Ccr),collegen Ⅳ (Col Ⅳ),procollagen Ⅲ(PC Ⅲ),laminin(LN),and improvement of urinary protein(uPro),urinary ?_2-microglobulin(?_2-MG)and clinical symptoms and signs were observed.Results:After treatment of Shenshuai Capsule,BUN,SCr,Col Ⅳ,PC Ⅲ,LN,urinary protein and ?_2-MG decreased and Ccr increased in the treatment group,with a significant differences between the two group in the above mentioned indexes except LN(P
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AIM: To explore the effect of Shenshuai Capsule on renal functio n, NO and TNF-? in CRF rat's blood. METHODS: Wister rats were fed with adenine to establish the chronic renal insufficiency anemia model, and then they were divided into three groups and fed with Shenshuai Capsule (high or low dosage) and Niaoduqing proup, respec tively. Kidney function index and the levels of NO and TNF-? in blood of CR F rats were measured. RESULTS: The comparison of renal function between the treatment gro up (high dosage) and the Niaoduqing group were significantly different respectiv ely. At the same time, Shenshuai Capsule can increase the NO of CRF rat's blood and reduce the TNF-?. CONCLUSION: Shenshuai Capsule can improve renal function of CRF rat , simultaneously raise the NO of CRF rat's blood and reduce the TNF-?. The lat ter may be one of the mechanism of action that Shunshuai Capsule can delay the r enal failure.