Effect of Omethoate on DNA in Mice Testicle Cells / 环境与健康杂志

Objective To study the adverse effect of omethoate on DNA in mice testicle cells in vivo.Methods 24 mice were randomly divided to 4 groups:control(no omethoate),1,2 and 4 mg/kg.omethoate was given by gavage one time a day for consecutive 7 days.DNA damage was detected by single cell gel electrophoresiss (SCGE).Results At the concentration of 1,2,4 mg/kg,omethoate induced DNA damage in mice testicle cells in vivo with an obvious dose-effect relationship(r=0.969 5).Conclusion Omethoate may cause DNA damage in mice testicle cells.