RESUMO
Objective To investigate the influence of safe sex education and antiretroviral therapy (ART) on human immunodeficiency virus (HIV) antibody sero-conversion status among HIV-discordant spouses.Methods Totally 1 258 HIV/acquired immunodeficiency syndrome (AIDS) cases and their spouses were enrolled and the related information was collected during 2005 to 2007.The HIV negative spouses were tested for HIV antibody once every 6 months.The effects of safe sex education and ART on sero-conversion status of HIV-discordant spouses were analyzed.The date were analyzed by x2 test.Results Without any intervention,505 out of 1 258 HIV/AIDS spouses were positive for HIV test,with the HIV natural spousal transmission rate of 40.1％.Among 442 blood source and 816 sexual source index HIV cases,HIV was positive in 103 and 402 of their spouses,respectively,with the HIV transmission rates between couples of 23.3％ and 49.3 ％,respectively.HIV transmission rate in sexual source group was higher than that in blood source group (x2 =80.421,P＜0.01).Among 608 male and 650 female index HIV cases,HIV was positive in 333 and 172 of their spouses,respectively,with the HIV transmission rates between couples of 54.8％ and 26.5％,respectively.Rate of HIV transmission from men to women was higher than that from women to men (x2 =104.770,P＜0.01).Among 753 HIV discordant couples,only 5 spouses had HIV sero-conversion (0.7％) after comprehensive intervention measures during 5 years of follow-up period.Among 31 HIV/AIDS patients who were only accepted safe sex education,3 of their spouses were HIV positive (9.7％).The transmission rate was lower than that in patients without any intervention (40.1％) (x2 =11.760,P＜0.01).Among 722 HIV/AIDS patients received ART,2 of their spouses were HIV positive (0.3 ％),which was lower than the transmission rate (9.7％) in ART-na(i)ve group (x2=39.821,P＜0.01).Conclusion Safe sex education should be implemented throughout the health management of HIV/AIDS patients and their spouses.If possible,early ART should be carried out to reduce the risk of HIV transmission between married couples.
RESUMO
Objective To study the management status of HIV-discordant family in Henan province from 2006 to 2010.Methods Data on AIDS infected family from “AIDS Infected Family Follow-up Management and Analysis System” was collected and analized to uderstand the management status of HIV-discordant situation.Results The sero-conversion rates of HIV-discordant spouse were 1.94/100 person-years in 2006,1.79/100 person-years in 2007,0.59/100 person- years in 2008 and 0.41/100 person-years in 2009,showing the yearly decrease.Regarding the number of sero-conversion in the same year,male was significantly higher than female in 2007,but not in the other years.The ratio on the course of sero-conversion which was ＞2.5 years was increasing.Frequency of most HIV-discordant couples' sexual activities was 1-4 times/month with consistent use of condoms.Conclusion The population of HIV-discordant spouse in Henan province was stable.Regarding management of those HIV-discordant spouse,the acceptance on the rate of test rate was increasing.The course of sero-conversion was also increasing,with most HIV-discordant couples insist on condom use while the sero-conversion rate of HIV-discordant spouse appeared to be low.