Clinical usefulness of KolomarkTM, a Korean radio-opaque marker for measuring colon transit time / 대한내과학회지

BACKGROUND: Among various methods for measuring colon transit time, radio-opaque marker study is simple, reproducible and economical method. The commonly used marker, Sitzmarks (Konsyl Pharmaceuticals Inc. Texas) had limitation in its use due to expensiveness and difficulty in importation. We thought that the new domestic marker comparable to Sitzmarks is necessary and made a Kolomark (Korean colon marker)TM. The comparison of radio-opaqueness and the measurement of colon transit times by two markers were done. METHODS: In two 1000 ml beakers, 350 ml of rice-gruel, several chicken-bones and ten rings of Sitzmarks and KolomarkTM were mixed separately. Then, X-ray films of the two beakers were taken. The digital image file was analyzed by Image and the value of pixels were obtained. These were repeated five times. Colon transit times were measured in 60 healthy persons stratified by age, 30 by Sitzmarks and 30 by KolomarkTM. RESULTS: The mean value of pixel of KolomarkTM was much lower than that of Sitzmarks. The difference between background or beaker and KolomarkTM was much greater than that of Sitzmarks . There was no significant difference between colon transit time studied by Sitzmarks and KolomarkTM. CONCLUSION: KolomarkTM, a more radio-opaque and cheaper marker than Sitzmarks will be applied usefully for measuring colon transit time.

The Development of Kolomark(TM), A Korean Radio-opaque Marker for Measuring Colon Transit Time / 대한소화관운동학회지

BACKGROUND/AIMS: Colon transit time is a useful method for assessing colonic motor function and classifying the type of idiopathic chronic constipation. Among various methods, a radio-opaque marker study is a simple, reproducible and economical method. The commonly used marker, Sitzmarks(R)(Konsyl Pharmaceuticals Inc. Texas) had limitations in its use due to expensiveness and difficulty in importation. We thought that a new domestic marker comparable to Sitzmarks(R) was necessary and we developed Kolomark (Korean colon marker)(TM). The radio-opaqueness of Kolomark(TM) was compared to that of Sitzmarks(R). METHODS: In two 1000ml of beakers, 350ml of rice-gruel, several chicken-bones and ten rings of Sitzmarks(R) and Kolomark(TM) were mixed separately. Then, X-ray films of the two beakers were taken. The digital image file was analyzed by image(R), a medical image processing program, and the value of pixels were obtained. These were repeated five times. RESULTS: The mean value of pixel of Kolomark(TM) was much lower than that of Sitzmarks(R). The difference between background or beaker and Kolomark(TM) was much greater than that of Sitzmarks. CONCLUSION: Kolomark(TM), a Korean colon marker which is more radio-opaque and cheaper than Sitzmarks(R) is developed and further study is needed to prove its clinical usefulness.