Curative effect ofDan'e-Fukang soft extract for dysmenorrhea associated with endometriosis / 国际中医中药杂志

Objective To investigate the efficacy of Dan'e-Fukang soft extract for dysmenorrhea associated with endometriosis.Methods A total of 88 patients with dysmenorrhea associated with endometriosis were randomly recruited into a treatment group and a control group. The patients in the control group were treated with gestrinone, while the patients in the treatment group were treated withDan'e-Fukang soft extract. The therapeutic efficacy, improvement of dysmenorrhea and drug safety after the treatment were observed in both groups.Results The total effective rate of in the treatment group(95.45%, 42/44), was apparently higher than that in the control group(81.82%, 36/44)(χ2=4.062,P<0.05). The dysmenorrhea improvement in the treatment group was better than that in the control group and also better than that before treatment in both groups(allP<0.05). The adverse reaction rate in the control group(22.73%,10/44) was higher than that in the treatment group(9.09%, 4/44)(χ2=5.906,P<0.05).ConclusionsDan'e-Fukang soft extract has a definite clinical efficacy for dysmenorrhea associated with endometriosis, can ameliorate the symptoms of dysmenorrhea.

The influence of Dan'e-Fukang soft extract on anxiety and depression of edometriosis patients / 国际中医中药杂志

Objective To explore the influence of Dan'e-Fukang soft extract on anxiety and depression of edometriosis patients.Methods 83 patients with endometriosis were randomly divided into a treatment group,treated with Dan'e-Fukang soft extract and a control group,treated with Gesrtinone capsules.Gynecological examination,pelvic B-mode ultrasonopgraphy,liver function,kidney function and CA 125 were detected before and after the treatment.The alteration of dysmenorrhea pain,menstrual blood volume,and adverse reactions were observed.Self-rating Depression Scale (SDS) and self-rating Anxiety Scale (SAS) were used to test the patients after treatment.Results ① Endometriosis effective rate of the treatment group and the control group were 95.35％ and 100.0％ respectively.② SAS and SDS score of the treatment group were (48.56± 5.39) and (50.35 ± 6.76) respectively before treatment,(33.43 ± 4.52) and (35.54± 4.68) respectively after treatment.The score of control group were (46.92±6.35) and (53.41 ±7.00) before treatment (37.56±5.64)and (42.87± 5.79) respectively after treatment.The scores had no significances between the two groups before the treatment,but had significant difference after the treatment(P＜0.05).Conclusion Dan'e-Fukang soft extract has exact effects on endometriosis,and its effects on mood are partly independent from endomet riosis.

Standardization of the quality control parameters of the Tamarindus indica L. soft extract

Introduction: Tamarindus indica L or Tamarind as commonly known is a medicinal plant witha broad spectrum of application in medicine. Tamarind is the most useful plant for liver disorders treatment in Cuba and The Caribbean. People use it as decoction and have to take up to four liters a day of this preparation, because the use of alcohol in the Tamarind fluid extracts prevent its use in patient with lever desorders. Objective: the aim of this study was the preliminary establisment of quality control parameters of the Tamarindus indica L soft extract as a novel alcohol-free active ingredient for solids pharmaceutical formulation. Methods: organoleptics properties, total solids, relative density, pH, and total ashes were stablished. The polyphenols content was evaluated as a chemical marker using Folin-Ciocalteau spectrophotometric method. The WHO methodology was followed for the establishment of limits for each one of the parameters...

Introducción: el Tamarindus indica L o tamarindo, como se le conoce comúnmente, es una planta medicinal con un amplio espectro de aplicación en la medicina. Es la más utilizada en Cuba y en el Caribe para los trastornos hepáticos. La población la utiliza en forma de decocción y consume alrededor de 4 L/d de esta preparación, porque el contenido de alcohol del extracto fluido de tamarindo impide su utilización en pacientes con estas enfermedades. Objetivo: establecer de forma preliminar los parámetros de control de calidad en el extracto blando de las hojas de Tamarindus indica L como un nuevo ingrediente activo libre de etanol, para la preparación de formas farmacéuticas sólidas. Métodos: se evaluaron las propiedades organolépticas, sólidos totales, densidad relativa, pH y cenizas totales. Se evaluó el contenido de polifenoles como marcador para el control de calidad de este extracto utilizando el método de Folin Ciocalteau. Se empleó la metodología propuesta por la Organización Mundial de la Salud para el establecimiento de los límites de control...

Formulación de comprimidos de tamarindo por el método de granulación húmeda / Formulation of tamarind tablets using the wet granulation method

El objetivo de este trabajo fue la formulación de tabletas farmacéuticas para lo cual se empleó como principio activo el extracto blando de las hojas de la especie Tamarindus indica L. Se utilizó el método de elaboración de tabletas por granulación húmeda a escala de laboratorio. Se prepararon 3 formulaciones en las que se varió las cantidades de lactosa, Aerosil®, celulosa microcristalina y croscarmelosa sódica. Se obtuvieron 3 formulaciones con características adecuadas para el proceso de producción de tabletas, de las cuales la número 3 fue la que mostró mejor calidad tecnológica. Se encontró una relación directa entre la cantidad de desintegrante añadido y el tiempo de desintegración, por lo que deberá estudiarse el efecto de este excipiente para la optimización de esta formulación

The objective of this paper was to prepare tablets using Tamarindus indica L. leaf soft extract as active ingredient. The classic method for manufacturing tablets by means of wet granulation at lab scale was used. Three formulations were prepared in which the quantities of excipients lactose, Aerosil®, microcrystalline cellulose and croscarmellose sodium varied. Three formulations were obtained with adequate characteristics in the manufacturing process but the number 3 exhibited the best technological quality. For further optimization of this formulation, the effect of the excipient must be studied because there was direct relationship between the added amount of disintegrant and the disintegration time

Content Determination of Paenol in Liuwei Dihuang Soft Ectract by HPLC / 中国药房

OBJECTIVE: To establish the HPLC method for the content determination of paenol in Liuwei dihuang soft extract. METHODS: The octadecylsilyl silicagel was used as filter. Mobile phase consisted of methanol-water(70 ∶ 30) at detection wavelength of 274 nm. The flow rate was 0.8 mL?min-1 and the column temperature was room temperature. RESULTS: The linear range of paeonol was 50～300 ?g?mL-1(?g?mL-1) with an average recovery of 99.63%(RSD=1.26%, n=6). CONCLUSION: This method is sensitive, accurate and reproducible for quality control of Liuwei dihuang soft extract.