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1.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 358-365, 2018.
Artigo em Inglês | WPRIM | ID: wpr-812394

RESUMO

One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 μg·mL.


Assuntos
Alcaloides , Química , Antibacterianos , Química , Farmacologia , China , Dicroísmo Circular , Dicetopiperazinas , Química , Staphylococcus aureus Resistente à Meticilina , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Penicillium , Química , Resorcinóis , Química , Farmacologia , Rhizophoraceae , Microbiologia , Áreas Alagadas
2.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 358-365, 2018.
Artigo em Inglês | WPRIM | ID: wpr-773605

RESUMO

One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 μg·mL.


Assuntos
Alcaloides , Química , Antibacterianos , Química , Farmacologia , China , Dicroísmo Circular , Dicetopiperazinas , Química , Staphylococcus aureus Resistente à Meticilina , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Penicillium , Química , Resorcinóis , Química , Farmacologia , Rhizophoraceae , Microbiologia , Áreas Alagadas
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