RESUMO
Spindle cell lipoma (SCL), also called as pleomorphic adenoma, is a rare variant of lipoma histopathologically characterized by an admixture of mature fat cells with spindle cells and occasionally mast cells with myxoid connective tissue stroma and thick bends of birefringent collagen. Although buccal mucosa is the most common location for oral lipomas, for SCL, it is an exceedingly rare location. We report a case of an asymptomatic swelling of buccal mucosa that simulated the features of neurofibroma on histopathological examination, and the final diagnosis of SCL was made on the basis of immunohistochemical features. This is the first documentation of oral SCL using SOX10 to achieve the final diagnosis.
RESUMO
No abstract available.
Assuntos
Feminino , Humanos , Lipoma/patologia , Neoplasias Faríngeas/patologiaRESUMO
PURPOSE: Spindle cell lipoma(SCL) is an uncommon subcutaneous soft tissue neoplasm that arises in the shoulder and posterior neck of older male patients. The imaging appearance of SCL is not pathognomonic and can display some features overlapping with liposarcoma. We report a case of SCL on the posterior neck. METHODS: The patient is a 50-year-old man with a slowly enlarging subcutaneous mass on the right side of posterior neck. Computed tomographic imaging revealed a 7.0cm sized, well-circumscribed, heterogenous and fatty mass with enhanced solid components. Whole body Fluorine-18 Fluorodeoxyglucose Positron emission tomogram(FDG PET-CT) showed little increase of FDG uptake on the right posterior neck and there was no distant metastasis. RESULTS: The mass was surgically removed. The resection margin was free of tumor on frozen biopsy. Histopathologic examination indicated spindle cell lipoma consisting of a mixture of mature adipocytes and uniform spindle cells within a matrix of mucinous material. CONCLUSION: Although CT image of the solitary mass in posterior neck is similar with the one of liposarcoma, we should consider that it may be a spindle cell lipoma if PET-CT and other systemic studies reveal no distant metastasis. And we should perform fine needle aspiration to differentiate SCL from malignant lesions.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Adipócitos , Biópsia , Biópsia por Agulha Fina , Elétrons , Lipoma , Lipossarcoma , Mucinas , Pescoço , Metástase Neoplásica , Ombro , Neoplasias de Tecidos MolesRESUMO
Spindle cell lipoma is a benign, subcutaneous neoplasm typically located on the neck, back and shoulder of men. Pseudoangiomatous spindle cell lipoma is a rare variant of spindle cell lipoma that is characterized by non-vascular branching spaces. A 64-year old man presented with 2 masses on the abdomen. Although 1 tumor had a very low fat component, it could be histologically diagnosed as pseudoangiomatous spindle cell lipoma due to CD 34 positive spindle cells, ropey collagen and blood vessels. We report a case of pseudoangiomatous spindle cell lipoma on the abdomen, which was diagnostically difficult due to a scanty fat component.
Assuntos
Humanos , Masculino , Abdome , Vasos Sanguíneos , Colágeno , Lipoma , Pescoço , OmbroRESUMO
Spindle cell lipoma is a benign tumor composed of ropey collagen, myxoid stroma, CD34-positive spindled cells, and mature fat. The variable proportion of these elements among different cases of the neoplasm makes diagnosis difficult. Furthermore, numerous variants have been reported, including pseudoangiomatous spindle cell lipoma, angiomatous spindle cell lipoma, fibrous spindle cell lipoma, and low-fat or fat-free spindle cell lipoma. Here we report a case of low-fat, fibrous spindle cell lipoma in which fat is noted to be present in <5% of the tumor, whereas fibrous collagenous stroma is predominant.
Assuntos
Colágeno , LipomaRESUMO
Spindle cell lipoma, an entity first described in 1975, accounts for about 1.5% of adipocytic neoplasms and is outnumbered by conventional benign lipomas by approximately 60 to 1. We report an unusual pseudoangiomatous variant of spindle cell lipoma on the right thigh of a 78-year-old man. The lesion had the features of typical spindle cell lipoma which was composed of mature fat cells and uniform spindle cells in a mucoid matrix with collagen bundles. In addition, the lesion exhibited irregular, branching spaces with villiform connective tissue projections, giving a striking angiomatoid appearance. Immunohistochemically, the spindle cells were positive for CD34, and lining cells of pseudoangiomatous spaces were negative for CD31, factor VIII-Ag.
Assuntos
Idoso , Humanos , Adipócitos , Colágeno , Tecido Conjuntivo , Lipoma , Greve , Coxa da PernaRESUMO
Spindle cell lipoma is an unusual and benign neoplasm, which normally occurs in middle age to older individuals oh the posterior neck, shoulders, and upper part of the back in the form of a solitary, slowly growing, painless, and subcutaneous nodule. We report a case of spindle cell lipoma on the right forearm of a 49-year-old female. Histopathologic examination revealed that the subcutaneous tumor was composed of mature fat cells and uniform spindle cells within a mucinous matrix. In some areas, the spindle cell proliferation was dominant due to variation in the ratio of spindle cells to mature fat cells. Vascularity was prominent in many parts of the tumor, and there were numerous mast cells scattered throughout the tumor. Immunohistochemically, the spindle cells were positive for vimentin and CD34, while S-100 protein and actin were not expressed.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Actinas , Adipócitos , Proliferação de Células , Antebraço , Lipoma , Mastócitos , Mucinas , Pescoço , Proteínas S100 , Ombro , VimentinaRESUMO
Spindle cell lipoma (SCL) is a relatively uncommon, benign tumor that usually presents in the subcutaneous fat of adult men. Histopatholgical findings show the lipomatous tissue to be replaced by a mixture of uniform spindle cells and mature fat cells closely within a mucoid matrix. We report a first case of SCL in a 24-year-old female. She had a solitary subcutaneous mass on right flank. Immunohistochemical staining shows positive for vimentin, CD34, but negative for S-100 protein. The patient was excised and showed no evidence of recurrence.
Assuntos
Adulto , Feminino , Humanos , Masculino , Adulto Jovem , Adipócitos , Lipoma , Recidiva , Proteínas S100 , Gordura Subcutânea , VimentinaRESUMO
A 33-year-old woman developed a pea-sized, painless, pedunculated nodule on the right palm. Microscopically, it consists of an intricate mixture of lipocytes and uniform spindle cells that was closely associated with a varying number of short bundles of collagen fibers. The lesion had been excised and showed no evidence of recurrence.
Assuntos
Adulto , Feminino , Humanos , Adipócitos , Colágeno , Lipoma , RecidivaRESUMO
A 50-year-old man developed 3cm sized, well-marginated, subcutaneous mass on the right upper back. Histopathologic finding showed the lipomatous tissue was replaced by a mixture of uniform spindle cells and mature fat cells that were closely associated with a mucoid matrix and a varying number of collagen fibers. The patient had been treated with excision and showed no evidence of recurrence.