Repair of large traumatic tympanic membrane perforation using ofloxacin otic solution and gelatin sponge / Reparo de grande perfuração da membrana timpânica traumática utilizando solução otológica de ofloxacina e curativo de Gelfoam®

Abstract Introduction Traumatic large tympanic membrane perforations usually fail to heal and require longer healing times. Few studies have compared the healing and hearing outcomes between gelatin sponge patching and ofloxacin otic solution. Objectives To compare the healing outcomes of large traumatic tympanic membrane perforations treated with gelatin sponge, ofloxacin otic solution, and spontaneous healing. Methods Traumatic tympanic membrane perforations >50% of the entire eardrum were randomly divided into three groups: ofloxacin otic solution, gelatin sponge patch and spontaneous healing groups. The healing outcome and hearing gain were compared between the three groups at 6 months. Results A total of 136 patients with large traumatic tympanic membrane perforations were included in analyses. The closure rates were 97.6% (40/41), 87.2% (41/47), and 79.2% (38/48) in the ofloxacin otic solution, gelatin sponge patch, and spontaneous healing groups, respectively (p = 0.041). The mean times to closure were 13.12 ± 4.61, 16.47 ± 6.24, and 49.51 ± 18.22 days in these groups, respectively (p < 0.001). Conclusions Gelatin sponge patch and ofloxacin otic solution may serve as effective and inexpensive treatment strategies for traumatic large tympanic membrane perforations. However, ofloxacin otic solution must be self-applied daily to keep the perforation edge moist, while gelatin sponge patching requires periodic removal and re-patching.

Resumo Introdução As grandes perfurações traumáticas da membrana timpânica geralmente apresentam falha de cicatrização e requerem tempos de cicatrização mais longos; poucos estudos compararam os resultados de cicatrização e a audição dessas perfurações obtidos com curativo de Gelfoam® e solução otológica de ofloxacina. Objetivo Comparar os resultados de cicatrização de grandes perfurações traumáticas da membrana timpânica tratadas com Gelfoam®, solução otológica de ofloxacina e cicatrização espontânea. Método Perfurações traumáticas de > 50% de todo o tímpano foram divididas aleatoriamente em três grupos: tratamento com solução otológica de ofloxacina, com curativo de Gelfoam® e grupo de cicatrização espontânea. O resultado da cicatrização e o ganho auditivo foram comparados entre os três grupos após 6 meses. Resultados Foram incluídos nas análises 136 pacientes com grandes perfurações traumáticas de membrana timpânica. As taxas de cicatrização foram de 97,6% (40/41), 87,2% (41/47) e 79,2% (38/48) com a solução otológica de ofloxacina, curativo de Gelfoam® e grupos de cicatrização espontânea, respectivamente (p = 0,041). O tempo médio de cicatrização foi de 13,12 ± 4,61, 16,47 ± 6,24 e 49,51 ± 18,22 dias nesses grupos, respectivamente (p < 0,001). Conclusões O curativo de Gelfoam® e a solução otológica de ofloxacina podem servir como estratégias de tratamento eficazes e de baixo custo para grandes perfurações traumáticas de membrana timpânica. Entretanto, a solução otológica de ofloxacina deve ser autoaplicada diariamente para manter a borda da perfuração úmida, enquanto o curativo de Gelfoam® requer sua remoção e reaplicação periódicas.

Identification and management of inverted or everted edges of traumatic tympanic membrane perforations / Identificação e conduta nas perfurações traumáticas da membrana timpânica com bordas invertidas ou evertidas

Abstract Introduction: Most of traumatic tympanic membrane perforations have inverted or everted edges, however, the effects of inverted and everted edges on the spontaneous healing of the eardrum remain controversial. Objective: We investigated the influence of inverted or everted edges on the spontaneous healing of traumatic tympanic membrane perforations. Methods: The clinical records of patients with a traumatic tympanic membrane perforations who met the study criteria were retrieved and categorized into two groups, based on whether the eardrum was inverted or everted. The features along the edge of each inverted or everted eardrum were described using 30º and 70º endoscopes. Results: In total, 196 patients (196 ears) met the inclusion criteria; of these, 148 had inverted or everted eardrums while 48 did not. Of the 148 patients with inverted or everted eardrums, the perforation edges were everted in 77 patients, inverted in 44 patients, drooping in 17 patients, and both inverted and everted in 10 patients. The perforation shape was triangular in 18.9% of patients, sector-shaped in 11.5%, kidney-shaped in 14.2%, ovoid in 20.3%, and irregularly shaped in 35.1% of patients. The difference was not significant between the with and without inverted/everted eardrum edges groups in terms of the closure rate or closure time. Similarly, the difference was not significant between the with and without edge approximation groups in terms of the closure rate or closure time at the end of the 12-month follow-up period. Conclusion: This study suggests that endoscopic inspection can clearly identify inverted/everted eardrum edges using 30º and 70º endoscopes. The edge is glossy in inverted/everted eardrums, whereas the edge is rough and irregular in non-inverted/everted cases. The inverted/everted eardrums gradually became necrotic, but this did not affect the healing process. Additionally, edge approximation did not improve the healing outcome of traumatic tympanic membrane perforations.

Resumo Introdução: A maioria das perfurações de membrana timpânica traumáticas apresenta bordas invertidas ou evertidas; no entanto, os efeitos dessas configurações sobre a cicatrização espontânea do tímpano continuam a ser uma questão controversa. Objetivo: Investigar a influência de bordas invertidas ou evertidas sobre a cicatrização espontânea de perfurações traumáticas de membrana timpânica. Método: Os prontuários clínicos de pacientes com perfuração traumática de membrana timpânica que preencheram os critérios do estudo foram recuperados e categorizados em dois grupos, baseados na configuração invertida ou evertida das bordas da membrana timpânica. As características de configuração da borda de cada membrana foram descritas com o uso de endoscópios de 30º e 70º. Resultados: No total, 196 pacientes (196 orelhas) preencheram os critérios de inclusão; desses, 148 apresentavam bordas de membranas timpânicas invertidas ou evertidas, enquanto 48 não. Dos 148 pacientes, as bordas da perfuração estavam evertidas em 77 pacientes, invertidas em 44 pacientes, caídas em 17 pacientes e ambas invertidas e evertidas em 10 pacientes. O formato da perfuração era triangular em 18,9% dos pacientes, em forma de fatia de pizza em 11,5%, em forma de rim em 14,2%, ovoide em 20,3% e de forma irregular em 35,1% dos pacientes. A diferença não foi significante entre os grupos com e sem membrana timpânica invertida/evertida em termos de taxa ou tempo de fechamento. Da mesma forma, a diferença não foi significativa entre os grupos com e sem aproximação das bordas em termos de taxa de fechamento ou tempo de fechamento no fim do período de seguimento de 12 meses. Conclusões: Este estudo sugere que a avaliação com endoscópios de 30º e 70º pode identificar claramente as bordas invertidas/evertidas das perfurações de membranas timpânicas. A borda da perfuração timpânica em casos invertidos/evertidos é brilhante, enquanto a borda é áspera e irregular em casos não invertidos/evertidos. O rebordo timpânico invertido/evertido gradualmente torna-se necrótico, mas isso não afetou o processo de cicatrização. Além disso, a aproximação das bordas não melhorou o resultado da cicatrização.

Rupturas agudas de ligamento cruzado anterior. ¿Existe la cicatrización espontánea? / Anterior cruciate ligament acute ruptures. Is there spontaneous healing?

OBJETIVOS: Identificar pacientes que, con diagnóstico de ruptura aguda y completa del LCA, cicatrizaron espontáneamente; y si esta curación tiene relación con la edad, sexo, tipo de ruptura, tiempo de reposo y mecanismos del trauma. MATERIALES Y MÉTODOS: Se evaluaron 30 pacientes con ruptura aguda completa del LCA mediante diagnóstico clínico e imagenológico con resonancia magnética nuclear (RMN). Se utilizó para valoración subjetiva test de Lysholm e IKDC 2000. RESULTADOS: Todos los pacientes mejoraron de la primera a la segunda consulta, con resultados: Lachman (p<0.0406), pivot shift (p=0.071) y cajón anterior (p<0.001). En la segunda RMN de control, se observó el LCA con signos de cicatrización en la totalidad de los pacientes. Podría inferirse, con un seguimiento promedio de 12 meses para hombres (IC95% 6-17) y de 13 meses para las mujeres (IC95% 31max), una recuperación clínica prácticamente completa, así como también que la cicatrización se produciría independientemente de variables como la edad, sexo o tratamiento específico (p=0.795 y p=0.841). CONCLUSIÓN: A pesar de la limitación del tamaño del presente estudio, los objetivos planteados fueron alcanzados. Existiría la cicatrización espontánea del LCA y la misma no estaría asociada a la edad, sexo, ni a tratamientos específicos de fisioterapia o al uso de inmovilizadores; aunque sí, al reposo durante los primeros 3 meses post lesión. Tipo de estudio: Retrospectivo. Nivel de evidencia: IV.

OBJECTIVES: To identify patients who, with a diagnosis of acute and complete ACL rupture, healed spontaneously, and determine whether such healing is related to age, sex, type of rupture, resting time, and mechanisms of trauma. MATERIALS AND METHODS: Thirty patients with complete acute ACL rupture were evaluated by clinical diagnosis and Magnetic Resonance Image (MRI). Both Lysholm test and IKDC 2000 were used for subjective evaluation. RESULTS: All patients improved from the first to the second consultation, with results: Lachman (p <0.0406), pivot shift (p = 0.071), and anterior drawer (p <0.001). In the second control MRI, ACL with signs of healing in all patients were observed. With an average follow-up of 12 months for men (95% CI 6-17) and 13 months for women (95% CI 31max), a practically complete clinical recovery could be inferred, as well as healing taking place independently of variables such as age, sex, or specific treatment (p = 0.795 and p = 0.841). CONCLUSION: Despite the size limitation for the present study, the objectives set were achieved. There would be spontaneous ACL healing associated with a 3-month-post-injury resting time, but dissociated from age, sex, specific physiotherapy treatments, or the use of immobilizers. Type of study: Retrospective. Level of evidence: IV.

Management of horizontal root fractures by fabrication of canine protected occlusion using composite resin

Traumatic injuries of the face often involve root fractures especially in anterior teeth. The prognosis and the treatment of the root fracture depend on the extent of the fracture line, general health and patient compliance. This case report outlines a new conservative trial treatment modality to stabilize the maxillary central incisors with horizontal root fracture on the cervical to middle third by fabricating canine guidance to remove loading on the traumatized maxillary central incisors during eccentric movements and thus inducing spontaneous healing of the fractured line between the fragments. Radiographs after thirty months showed adequate healing with no signs of pathological changes including root resorption, ankylosis or displacement. Long term follow-up revealed that vitality, stability and aesthetics were maintained and the patient was satisfied with the outcome.

Healing Potential of the Transected Posterior Cruciate Ligament of the Rabbit

PURPOSE: We intended to investigate the spontaneous healing response of the posterior cruciate liga-ment(PCL) of the knee to the location of injury in a mature rabbit model. MATERIALS AND METHODS: In the group I(30 rabbits), PCLs were transected at femoral insertion site and in the group II(30 rabbits), they were transected at mid-substance. Subsequent changes were investigated by histological examination with Hematoxylin-Eosin(HE) staining, immunohistochemical analysis for growth factors and biomechanical test with Instron machine(model 4206). Sham operation was performed on the contralateral side, which was used as the control. RESULTS: On gross inspection, significant difference was not observed between the two groups but scar tissue was thicker in group II than group I. On histological examination and immuno-his-to-chem-i-cal study, there was no significant differnce too. On tensile stress test with Instron machine, ultimate tensile strength steadily increased with time, but it was significantly lower than control in both groups. The length of healed ligaments also increased with time in both groups. CONCLUSION: The spontaneous healing of the PCL can occur in the mature rabbit, yet there were no significant differences of healing characteristics between group I and II. The healed ligaments were elongated and biomechanical properties were far inferior to those of control. We expect the further study on spontaneous healing of PCL with more researches on the other factors which are not considered in this