RESUMO
Objective: To study the chemical constituents from the roots of Breynia fruticosa. Methods: The compounds were isolated by comprehensive column chromatography, and the structures were elucidated by spectral methods. Results: Thirteen compounds were isolated and elucidated, including four triterpenoids, friedelin (1), friedelinol (2), lupenone (3), and glochidiol (4); three steroids, including β-sitosterol (5), stigmastane-3β, 6β-diol (6), and β-sitosterylglucoside-6'-octadecanoate (7); two cerebrosides, including 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2-hydroxyoctadecanoyl) amido]-4, 8-octadecadiene-1, 3-diol (8) and 1-O-β-D-glucopyranosyl-(2S, 3S, 4R, 8Z)-2-[(2R)-2-hydroxypentacosanoylamino]-8-octadecene-1, 3, 4-triol (9); and four other compounds, including (-)-epicatchin (10), ε-caprolactone (11), aviculin (12), and vanillin (13). Conclusion: Compounds 3, 4, 6-9, and 11 are isolated from the plant of Breynia J. R. et G. Forst. nom. cons. for the first time, and compound 11 is isolated from the natural product for the first time.