RESUMO
Irritable bowel syndrome is a long-lasting disorder that affects a significant number of people worldwide. This comprehensive study explores the complexities of IBS, thoroughly investigating its classification, signs, and various treatment approaches. It emphasizes the nature of IBS symptoms, highlighting the importance of tailored treatment strategies that consider adjustments, medications, and psychological therapies. The study recognizes that each patient responds differently to treatments, underscoring the need for care. By shedding light on the nature of IBS and acknowledging experiences, this research aims to provide an updated and evidence-based understanding of managing IBS. The significance of an approach is emphasized, recognizing how health, psychological well-being, and lifestyle factors are interconnected in IBS. Alongside medication for symptom relief and therapies addressing aspects, dietary modifications play a vital role in improving patient outcomes and overall quality of life. This integrated strategy aims to address IBS's impact on health and overall well-being. In summary, this study provides information for healthcare professionals and researchers to provide an understanding of the complexities of IBS and advocate for a personalized and evidence-based approach to its treatment.
RESUMO
BackgroundOcular melanoma is a malignant tumor with a poor prognosis.To study its mode of pathogenesis and development is helpful for early diagnosis and treatment and improving prognosis. Objective This study was to analyze the location and pathological types of ocular melanoma,and explore the relationship of pathological types with prognosis of ocular malignant melanoma. Methods 110 clinical data and specimens of ocular melanoma were collected at West China Hospital,China.The specimens were examined by hematoxylin & eosin staining,immunochemistry and studying their ultrastructure.The growth location,histological classification,and their relationship with prognosis were analyzed and discussed.The clinicopathological records of the 1 l0 cases with ocular region malignant melanoma treated from January 1980 to December 2007 were analyzed.Results The primary locations of the tumors with respect to the tissue type were:66 cases in the uvea (60.00％ ),27 cases in the ocular surface tissue (24.55％),8 cases in the secondary lesion of orbit cavity (7.27％),7 cases on the eyelid skin (6.36％),and 2 cases in the lacrimal sac ( 1.82％ ).The neoplasm was classified according to pathological types:spindle-cell A type in 31 cases (28.18％ ),spindle-cell B type in 31 cases (28.18％),mixed-cell type in 25 cases (22.73％),epithelioid-cell type in 17 cases ( 15.46％ ) and other type in 6 cases (5.45％).The notability of diffusion or recurrence rate of the 5 pathological types showed statistical significance (x2 =14.463,P =0.006 ),and the rank in decending order was:other type,epithelioid-cell type,mixed-cell type,spindle-cell B type and spindle-cell A type.The clinical manifestations of ocular melanoma were dependent upon the lesion position without specificity.ConclusionsThe majority of the ocular malignant melanoma appears in the uvea and ocular surface tissue,and its common pathological types were spindle-cell type followed by mixed-cell type,epithelioid-cell type and other type.The highest recurrence rate is in other type of ocular malignant melanoma.Ophthalmologist should be aware of the clinical manifestation of ocular malignant melanoma.