RESUMO
Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.
Assuntos
Humanos , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Produtos Biológicos/isolamento & purificação , Produtos Biológicos/farmacologia , Descoberta de Drogas/tendências , Tinha/tratamento farmacológico , Tinha/epidemiologia , Antifúngicos/uso terapêutico , Arthrodermataceae/efeitos dos fármacos , Produtos Biológicos/uso terapêuticoRESUMO
OBJECTIVE:To establish a method to distinguish between synthetic caffeine and natural caffeine METHODS:To identify the related substances obtained from synthetic caffeine and natural caffeine by HPLC,TLC,fluorescence spectrophotometry and X-ray powder diffraction RESULTS:Synthetic caffeine and natural caffeine can be identified by testing the related substances in them CONCLUSION:Using the described method,synthetic caffeine and natural caffeine can be discriminated accurately