Systemic lupus erythematosus retinopathy in a 32-year-old female: Report of a case.

Systemic lupus erythematosus (SLE) is rare in India with a prevalence of 3 in 100,000.[1] SLE retinopathy is second most common ocular manifestation after keratoconjunctivitis sicca and a major vision‑threatening complication of SLE with an incidence of upto 29% in patients with systemic active disease.[2] We present this photo essay to illustrate the classic features of SLE retinopathy and the co‑ordinated role of Ophthalmologist (including sub‑specialties) with Physicians (Rheumatologist and/or Dermatologist) in managing these multi‑system and multi‑organ autoimmune disorders.

Expression of DNAM-1 on T cells subsets from patients with systemic lupus erythematosus / 中国免疫学杂志

Objective:To investigate functional of DNAM 1 antigen in T cell subsets activation process from patients with SLE and determine whether they are correlated with the pathogenesis of SLE.Methods:The peripheral blood monouclear cells from 31 SLE and 30 healthy volunteers were stimulated with PHA.Those cells were quantified using flow cytometric analysis with three colour immunofluorescent staining method.The levels of anti dsDNA,complement C 3 and C 4 were measured as well as.Results:The percentages of DNAM 1 positive from SLE on CD + 4 and CD + 8 T cells were increased,compared with that of the controls (P0.05).The DNAM 1 expression on CD + 8 cells from SLE showed relatively high positive correlation with SLEDAI and anti dsDNA antibody and that on CD + 8 T cells have negative correlation with C 3 and C 4 complement(P0.05).Conclusion:There are some abnormal activated T cell subsets in SLE.The expression of DNAM 1 on CD + 4?CD + 8 T cells with active SLE are increased.That on CD + 8 cells are correlated to SLEDAI?anti dsDNA antibody?C 3 and C 4 complement and there is a clinical correlation with it's levels.So DNAM 1 may play an important roles in the mechanisms of immune activation and immunopathology in SLE.