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China Pharmacy ; (12): 1241-1246, 2019.
Artigo em Chinês | WPRIM | ID: wpr-816971

RESUMO

OBJECTIVE: To predict the anti-inflammatory active components and mechanism of couplet medicine of Notopterygium incisum-Angelica pubescens. METHODS: According to the principle of oral bioavailability≥30% and drug- likeness≥0.18, active components of N. incisum and A. pubescens were screened; TCMSP was used to predict and screen the potential target of them. Using “Anti-inflammatory” as keyword, inflammatory related target genes were retrieved from human gene database Genecards. Common target was screened by mapping the target genes of active ingredients from couplet medicine of N. incisum-A. pubescens. The active ingredient-target network was established by using Cytoscape 3.5.1 software. The screened targets were used to construct the target protein interaction (PPI) network on the STRING V 10.5 platform. Its anti-inflammatory mechanism was studied by KEGG signaling pathway and GO biological enrichment analysis. RESULTS: Totally 15 active components such as coumarin, beta-sitosterol, ammidin, nodakenin were selected from couplet medicine of N. incisum-A. pubescens. Acting on 49 targets such as transcription factor AP-1, PI3-kinase subunit gamma, estrogen receptor, they mainly involved 19 signaling pathways such as hepatitis B and cell apoptosis, and were involved in 47 biological processes such as regulating inflammatory response and prostaglandin biosynthesis. CONCLUSIONS: The anti-inflammatory mechanism of active components of couplet medicine of N. incisum-A. pubescens on multi-target, multi-channel and multi-biological processes is predicted, and it points out the direction for further anti-inflammatory mechanism study.

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