Leukemia Therapy: Mechanisms of Drug Resistance and Investigational Strategies.

Certain types of leukemia are amongst the first neoplasias to be “cured” with relatively high 5-year remission rates. This is largely due to targeted therapeutics. However, considerable resistance to tumor-specific targeting drugs has developed due to the presence of abundant cancer stem cells, profound genetic diversity, redundant growth/survival pathways and residual disease. Although these issues propose a challenge, they also provide the opportunity for novel innovations of therapy which currently include the development of multi-target kinase inhibitors, multiple drugs acting on multiple targets, key upstream targets covering multiple downstream targets and the future direction of hybrid molecules targeting two or more targets in different pathways.

Application of high-throughput sequencing technology in lung cancer research / 肿瘤研究与临床

Over the past decade,the treatment of lung cancer gradually develops to individulized molecule targeted therapy for certain driver gene from chemotherapy based on histological features.High-throughput sequencing (HTS) technology has many advantages,such as higher throughput,shorter running time,less cost and so on.Further mining analysis to the massive data generated by HTS can reveal the mechanism of the development of lung cancer at genome level and seek new driver gene as the target of targeted therapy,it also can identify the gene alternatives that confer resistance to certain targeted therapy.

HSP70: probable role in Pathogenesis and therapeutics of oral lichen planus / HSP70: provável papel na patogênese e terapêutica de líquen plano oral

Objective: To evaluate a potential role of HSP70 in the pathogenesis of oral lichen planus (OLP). Materials and methods: The study sample comprised of 30 samples of histopathologically confirmed cases of OLP, which were grouped on the basis of the thickness of the epithelial layer into atrophic, normal (classical) and acanthotic. An immunohistochemical analysis of the expression of HSP-70 protein was done, followed by a quantitative and qualitative analysis of the stained layers. The results were statistically analyzed. Results: An increased expression of HSP70 was noted in the basal and suprabasal cells of the epithelium of OLP. A higher count and intensity of HSP70 expression was seen in the basal layer of the epithelium. Greater expression was noted in the epithelium of the atrophic group. Conclusion: The expression pattern of HSP70 positively implicates it in the pathogenesis of OLP. A potential role of HSP 70 usage as therapeutic modality is suggested.

Objetivo: Avaliar o potencial papel do HSP70 na patogênese do líquen plano bucal (LPB). Materiais e métodos:A amostra foi composta de casos histologicamente confirmados de LPB, os quais foram agrupados em função da espessura da camada epitelial em atrófica, normal (clássica) e acantose. Uma análise imuno-histoquímicada expressão da proteína HSP70 foi feita, seguida por uma análise quantitativa e qualitativa dascamadas coradas. Os resultados foram analisados estatisticamente. Resultados: Um aumento da expressãode HSP70 foi observado nas células basais e suprabasais do epitélio de LPB. A maior contagem e intensidadede expressão HSP70 foi vista na camada basal do epitélio. Maior expressão foi observada no epitélio do grupoatrófica. Conclusão: O padrão de expressão de HSP70 demonstrou uma ação positiva do mesmo na patogêneseda LPB. O uso do HSP70 como modalidade terapêutica do LPB é sugerido.