Anti-Hyperglycemic Effect of Tecomella undulata Extract by Ameliorating Pancreatic Dysfunction in Streptozotocin Induced Diabetic Albino Rats.

Objective: The primary objective of the present investigation is to evaluate the antihyperglycemic activity of the 50% ethanolic extract of the Tecomella undulata Seem. (TUE) bark in the streptozotocin induced diabetic rats. Methods: Single intraperitoneal injection (i.p.) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes is wistar albino rats. The induction of diabetes was confirmed after 3 days after STZ injection and rats with fasting blood glucose levels greater than 200 mg/dl were considered to be diabetic used in the experiment. TUE at a once a daily dose of 250 mg/kg, and 500 mg/kg, p.o. along with glibenclamide 600μg/kg, p.o. was also given for 21 days. On the 21st day rats from all the groups fasted overnight and the blood was collected from the puncturing the retro orbit of the eye under mild ether anesthetic condition. The oral acute toxicity studies did not show any toxic effect till the dose at 2000 mg/kg. Results: The statistical data indicated that the different doses of the TUE significantly decreases the level of fasting blood glucose, total cholesterol, triglycerides, low density lipoprotein and increase high density lipoprotein in STZ induced diabetic rats. This result indicated that T. undulata extract can protect pancreatic β-cells from STZ-induced damage which is confirmed by the results of the histopathological examination of the pancreas. Conclusion: Our investigation has clearly indicated that the bark extract of Tecomella undulata Seem. showed remarkable antihyperglycemic activity due to its possible systematic effect involving in the pancreatic and extra pancreatic mechanism. Moreover, the antihyperlipidemic activity was exerted possible by lowering the higher level of lipid profile.

Traditional uses, phytochemistry and pharmacology of Tecomella undulata- A review

The aim of the present review is to present comprehensive information of the traditional uses, phytochemistry and pharmacology of Tecomella undulata (Family, Bignoniaceae) and to discuss future scope of research. Tecomella undulata (TU) is commonly known as desert teak (ver. Rohiro) and is traditionally for treating liver and spleen diseases, tumours, conjunctivitis, hepatosplenomegaly, syphilis, gonorrhea, hepatitis, as a blood purifier and in wound healing. Compounds such as naphthaquinone derivative, iridoid glucoside, phytosterol, fatty alcohol, flavonols, flavonoid glucoside and triterpenoids have been reported from TU. Anti HIV, anti bacterial, anti microbial, immune modulator, analgesic and hepatoprotective activities have been reported from its various aerial parts. In the present review, attempts have been made to compile research reports on TU, to assess current research trends with possible future avenues of research.

A Phytopharmacological overview on Tecomella undulata G Don.

Tecomella undulata G. Don. is a popular medicinal plant has long been used in ayurvedic system of medicine. The plant has been found to exhibit diverse pharmacological activities. The present paper gives an account of updated information on its photochemical and pharmacological properties. The review of literature reveals that wide range of phytochemical constituents have been isolated from plant and it possesses important pharmacological activities like antibacterial, anticancer and its utility in treatment of certain ailments like syphilis, swelling, leucorrhoea and leucoderma, enlargement of spleen have also been reported. The reports are encouraging hence the herb must be extensively used for its therapeutic benefits. Also the study based on clinical trials should be carried out to support the usage of drug traditionally for treatment of various ailments.

Assessment of hepatoprotective effect of Tecomella undulata (Sm.) Seem., Bignoniaceae, on paracetamol-induced hepatotoxicity in rats

The aim of the present study was to validate the hepatoprotective activity of bark of Tecomella undulata (Sm.) Seem., Biognoniaceae, against paracetamol (PCM) induced hepatic damage. Chloroform soluble fraction (Fraction-I), acetone soluble fraction (Fraction-II), methanol soluble fraction (Fraction-III) and methanol insoluble fraction (Fraction-IV) of ethanolic extract of bark of T. undulata were evaluated for hepatoprotective activity against paracetamol induced hepatic damage using biochemical, morphological, functional and histopathological studies. The methanol soluble fraction (Fraction-III) was most potent among the four fractions studied in detail. Fraction-III showed significant hepatoprotective activity against paracetamol induced hepatic damage as evident by normalization of substantially elevated levels of aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and total bilirubin (TBil), decreased level of total protein (TP), increased wet liver weight and volume, increased thiopentone sodium induced sleeping time and abnormal histopathology. Present study showed that the Fraction-III of ethanolic extract of bark of T. undulata significantly restores physiological integrity of hepatocytes. Fraction-III did not show any sign of toxicity up to oral dose of 1500 mg/kg in mice.