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BACKGROUND@#Microwave ablation and radioactive seed implantation are therapeutic options for patients with advanced lung cancer and lung metastases lesion who are not surgical candidates. However, reports on therapeutic effectiveness and safety of the two combination treatments methods have been limited to small case series. This research was to assess the clinical outcome and safety of radioactive seed implantation combined with computed tomography (CT)-guided microwave ablation for the treatment of advanced lung cancer and lung metastases lesion.@*METHODS@#The clinical data of 21 advanced lung cancer and lung metastases patients who received treatment at author hospital during the period from May 2018 to December 2018 were retrospectively analyzed. The patients were divided into two groups by whether received extra percutaneous microwave thermal ablation therapy. The short-term effectiveness and safety were analyzed.@*RESULTS@#The efficacy of control group was 28.75%, and the efficacy of experiment group was 14.28%. The rate of adverse reaction between two groups has no significantly difference (P>0.05).@*CONCLUSIONS@#Seed implantation combined with CT-guided microwave ablation for advanced lung cancer and lung metastases is safety and effective.
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Objective: To observe the value of contrast-enhanced ultrasound (CEUS) and acoustic radiation force impulse (ARFI) elastography in evaluating efficacy of microwave ablation (MWA) on hepatic alveolar echinococcosis in rats. Methods: Totally 40 HAE rat models were divided into experimental group (n=30) and control group (n=10). Rats in experimental group underwent ultrasound-guided MWA, while those in control group received routine feeding. Routine 2D ultrasound, CEUS and ARFI were used to measure the maximum diameter of lesions before and 1 month later. The changes of mean gray scale ratio and shear wave velocity (SWV) in marginal zone of lesions in experimental group were compared with pathologic findings. Then the rats were all scarified, and routine HE staining, CD34 immunohistochemical staining and Masson staining were performed to count the microvessel density (MVD) and fibrosis area at the edge of lesions. Results: There were 19 rats (21 lesions) in experimental group and 10 rats (10 lesions) in control group. One month after MWA, the maximum diameter of lesions obtained with 2D ultrasound, CEUS and ARFI became smaller in experimental group (all P0.05). One month after MWA, the mean gray scale ratio of ablation edge in experimental group was lower, while SWV value was higher than that before (both P<0.001). MVD of the ablation edge in experimental group was lower than that in control group (P<0.001), and the fibrosis area of experimental group was higher than that of control group (P<0.001). MVD was positively correlated with the gray scale ratio at the ablation edge (r=0.541, P=0.011), and SWV was positively correlated with the fibrosis area of Masson (r=0.494, P=0.023). Conclusion: Both CEUS and ARFI had certain application value for evaluation on efficacy of microwave ablation for treatment of HAE in rat models.
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Objective To introduce the hydro-dissection technique and its application in ultrasound-guided percutaneous thermal ablation therapy of neck nodular lesions. Methods A total of 1 126 patients suffering from neck nodular diseases received percutaneous thermal therapy using radiofrequency ablation or microwave ablation from May 2005 to April 2013. As a part of the treatment procedure, ultrasound-guided injection of separating liquid was performed into between the target nodules and surrounding structures to form a separating zone prior to ablation. The roles of hydro-dissection technique in improving the safety of puncture route, reducing the thermal injury to normal tissues, and enhancing the curative effects of ablation were analyzed. Results Hydro-dissection technique was successfully performed in as many as fourteen parts related to the thyroids, parathyroids, submandibular glands and lymph nodes. The key points and ultrasonic characteristics of this maneuver were well established and understood. Compared with those not receiving the technique, those receiving the technique had significantly reduced heat damage to lesion-adjacent structures (0.7% vs 15%, P < 0.01) and decreased incomplete ablation rate of the lirst try (0.29% vs 7.4%, P < 0.01). Conclusion Hydro-dissection technique under ultrasound-guidance is easy to perform, has good repeatability and reliable effect; it may serve as a safe and effective supplementary measure for thermal ablation of various neck nodular lesions.