RESUMO
Objective To investigate the efficacy and safety of tiotropium bromide aerosol combined with salmeterol in the treatment of ACOS. Methods 76 patients with ACOS were enrolled in this study from October 2014 to November 2016. They were divided into experimental group and control group according to the random number table method. The test group was given tiotropium bromide combined with salmeterol Casson aerosol treatment, the control group was given salmeterol tacrolone aerosol treatment, compared the two groups of patients with clinical efficacy and adverse reactions. Results The total effective rate was 92.11% in the experimental group and 73.68% in the control group, the difference was statistically significant (Z = 4.547, P<0.05). The ACT score of the test group was higher than that of the control group, the CAT score was lower than that of the control group, the difference was statistically significant (P<0.05); The incidence of adverse reactions in the test group was 10.53%, the incidence of adverse reactions in the control group was 13.16%,the difference was not statistically significant (χ2 = 0.126). Conclusion Tiotropium powder combined with salmeterol tegon aerosol in the treatment of bronchial asthma-chronic obstructive pulmonary syndrome is reliable and worthy of clinical practice.
RESUMO
Objective To analyze the effects of salmeterol/fluticasone propionate aerosols fluticasone propionate and salmeterol joint tiotropium aerosol on pulmonary function and exercise tolerance in patients with chronic obstructive pulmonary disease (COPD),and to provide a theoretical basis for clinical treatment.Methods 119 COPD patients were selected in this study.They were randomly divided into 65 cases of seretide group and 54 cases of combined treatment group.Before treatment,three months after treatment and six months after treatment,the pulmonary function and 6MWD were measured in all patients.Results After 3 months,6 months of treatment,the FEV1,FEV1/FVC,FVC,6MWD of the combined treatment group had significant differences compared with before treatment (ta =-5.89,tb =-6.88,te =-8.46,tf =-8.86,ti =-10.74,tj =-8.52,tm =-9.37,tn =-13.04,all P ＜0.05).After 3 months,6 months of treatment,the FEV1,FEV1/FVC,FVC,6MWD in the control group had significant differences compared with before treatment (tc =-4.29,td =-7.19,tg =-6.16,th =-11.40,tk =-11.69,tl =-7.43,to =-11.71,tp =-10.53,all P ＜ 0.05).After 3 months of treatment,the differences of FEV1,FEV1/FVC,FVC between two groups were significant (tv =2.69,tq =6.74,tr =2.91,all P ＜ 0.05).In the control group,theFEV1,FEV1/FVC,FVC after 6 months of treatment had significant differences compared with after 3 months of treatment(ts =-2.50,tt =-9.46,tu =-1.65,all P ＜ 0.05).Conclusion Seretide and tiotropium aerosol aerosol can better improve lung function in patients with COPD and exercise tolerance,but the result of using two drugs to improve the patients'lung function was significantly better than seretide alone.