Foeniculum vulgare (hinojo): alternativa terapéutica femenina / Foeniculum vulgare (fennel): female therapeutic alternative

INTRODUCCIÓN: el Foeniculum vulgare es una planta medicinal de gran importancia por sus propiedades y valor nutricional. Los extractos del hinojo poseen propiedades terapéuticas ante cambios endocrinos, perturbaciones psicológicas, malestares y sintomatología presente en el ciclo vital de la mujer. OBJETIVOS: analizar información sobre las diferentes propiedades y efectos terapéuticos del F. vulgare en las distintas etapas del ciclo vital de la mujer. METODOLOGÍA: se realizó una búsqueda crítica y analítica del tema por medio de lenguaje controlado recopilado del MeSH y DeCs en metabuscadores científicos. RESULTADOS: el desarrollo de esta revisión fue viable debido a la variedad de literatura, estudios y ensayos clínicos internacionales de libre acceso de información relevante al tema. CONCLUSIÓN: esta planta puede ser empleada como tratamiento, prevención y como fuente de nutrientes; y sus extractos tienen un efecto importante en el ciclo vital de la mujer dependiendo se encuentre en menstruación, menopausia o postmenopausia.

INTRODUCTION: foeniculum vulgare is a medicinal plant of great importance for its properties and nutritional value.Fennel extracts possess therapeutic properties against endocrine changes, psychological disturbances, discomfort and symptomatology present in the vital cycle of women. OBJECTIVES: analyze information on the different properties and therapeutic effects of F. vulgare in the different stages of the life cycle of women. METHODOLOGY: a critical and analytical search of the topic was performed ,by means of controlled language compiled from MeSH and DeCs in scientific meta-search engines. RESULTS: the development of this review was feasible due to the variety of freely available international literature, studies and clinical trials of information relevant to the topic. CONCLUSIÓN: this plant can be used as a treatment, prevention and as a source of nutrients; and its extracts have an important effect on the vital cycle of the woman depending on whether she is in menstruation, menopause or postmenopause.

Comparative study of the toxicity of hydroethanolic extracts of the root and stem barks of Cassia sieberiana D.C. on Wistar rats

This study was aimed to evaluate and to compare the acute and subchronic toxicities of the hydroethanolic extracts of theroot (HECRB) and stem bark (HECSB) of Cassia sieberiana in rats. In acute toxicity study, animals were divided into 2groups (n = 3). Rats received the single dose of 5000 mg/kg of HECRB and HECSB extracts of C. sieberiana orally. Forthe subchronic toxicity, 4 groups (n = 6) were given daily 500 and 1000 mg/kg of extracts for 28 days. Animal behaviorswere observed after each treatment. Results showed that HECRB and HECSB were not toxic at 5000 mg/kg. The LD50was >5000mg/kg for both extracts. After repeated doses of 500 and 1000 mg/kg, both extracts did not significantly affectthe relative organs weight of treated rats. HECSB did not affect biochemical and hematological parameters. However,HECRB significantly increased parameters such as red and white blood cells, hemoglobin, volume globulaire moyen,teneur corpusculaire moyenne en hemoglobine, and triglycerides. This study showed that HECRB and HECSB are nottoxic. It contributes to a better knowledge of the toxicity of C. sieberiana used for the treatment of several diseases in Togo.

Physicochemical properties and acute lung toxicity of paclitaxel / oleyl chitosan nanoparticles / 中国药学杂志

OBJECTIVE: To prepare paclitaxel / oleyl chitosan nanoparticles (PTX / OCS-NPs) and to examine its physicochemical properties and acute lung toxicity. METHODS: The morphology and size were determined by transmission electron microscope (TEM). The average diameters and polydispersity index were evaluated by dynamic light scattering (DLS). Encapsulation efficiency (EE) and in vitro release were determined by high performance liquid chromatography (HPLC). RESULTS: The RESULTS of PTX/OCS-NPs were spherical in shape, uniform particle size and dispersed uniformly. The diameters of NPs were(292.4±20)nm, PDI less than 0.246 and Zeta potential was about 25 mV. The drug loading of PTX was 15.06%. The encapsulation efficiency of PTX was 48.96%. In vitro release study showed that the cumulative release of PTX from NPs were 41.41% and 56.23% respectively, within 48 h in phosphate buffered saline (PBS) pH 7.4 and pH 4.5. Acute toxicity showed that there was no change in the number of white blood cells in the blood, and the content of LDH in the bronchoalveolar lavage fluid was not changed. The RESULTS indicated that the drug delivery system has a good biosafety and biocompatibility. CONCLUSION: PTX / OCS-NPs have excellent physicochemical properties, high drug loading, with sustained release, no acute lung toxicity, that is expected to be a good delivery of paclitaxel and other difficult anti-cancer drug delivery system.

Fumigant and repellent properties of sesquiterpene-rich essential oil from Teucrium polium subsp. capitatum (L.)

OBJECTIVE@#To test fumigant and repellent properties of sesquiterpene-rich essential oil from Teucrium polium subsp. capitatum (L.).@*METHODS@#The fumigant toxicity test was performed at (27±1)°C, (65±5)% relative humidity, and under darkness condition and 24 h exposure time. The chemical composition of the isolated oils was examined by gas chromatography-mass spectrometry.@*RESULTS@#The major compounds were α-cadinol (46.2%), caryophyllene oxide (25.9%), α muurolol epi (8.1%), cadalene (3.7%) and longiverbenone (2.9%). In all cases, considerable differences in mortality of insect to essential oil vapor were observed in different concentrations and exposure times. Callosobruchus maculatus (C. maculates) (LC50=148.9 μL/L air) was more susceptible to the tested plant product than Teucrium castaneum (T. castaneum) (LC50=360.2 μL/L air) based on LC50 values. In the present investigation, the concentration of 3 μL /mL acetone showed 60% and 52% repellency against T. casteneum and C. maculatus adults, respectively.@*CONCLUSIONS@#The results suggests that sesquiterpene-rich essential oils from the tested plant could be used as a potential control agent for stored-product insects.

Fumigant and repellent properties of sesquiterpene-rich essential oil from Teucrium polium subsp. capitatum (L.)

Objective: To test fumigant and repellent properties of sesquiterpene-rich essential oil from Teucrium polium subsp. capitatum (L.). Methods: The fumigant toxicity test was performed at (27±1)°C, (65±5)% relative humidity, and under darkness condition and 24 h exposure time. The chemical composition of the isolated oils was examined by gas chromatography-mass spectrometry. Results: The major compounds were α-cadinol (46.2%), caryophyllene oxide (25.9%), α muurolol epi (8.1%), cadalene (3.7%) and longiverbenone (2.9%). In all cases, considerable differences in mortality of insect to essential oil vapor were observed in different concentrations and exposure times. Callosobruchus maculatus (C. maculates) (LC