Consideraciones anestésicas en recién nacido con atresia y fístula traqueoesofágica / Anesthetic Considerations in Newborns with Tracheoesophageal Fistula and Atresia

Introducción: La atresia esofágica es una malformación congénita poco frecuente, que consiste en un defecto en el desarrollo del intestino anterior hacia el esófago y la tráquea que se produce aproximadamente en la cuarta semana de gestación. Objetivo: Describir los resultados de la actuación anestesiológica en un paciente con atresia esofágica y fístula traqueoesofágico, así como las consideraciones anestésicas para el tratamiento de la entidad. Presentación de caso: Paciente a término, femenina, blanca, peso al nacer 2880 g, Apgar 8-9 al min de vida, con diagnóstico de atresia esofágica ante la presencia de distrés respiratorio al nacimiento, salivación excesiva con crisis de atragantamiento a las 6 h de nacida e imposibilidad de introducir una sonda nasogástrica lo que fue confirmado en una radiografía de tórax. Fue anunciada por cirugía pediátrica y se efectuó reparación de la fístula. Se exponen las consideraciones anestésicas a seguir en el manejo de este caso, relacionadas con: los fármacos anestésicos, reposición de volumen y la estrategia de ventilación mecánica. Conclusiones: La urgente resolución quirúrgica en recién nacidos con atresia esofágica es importante para su supervivencia, para disminuir las complicaciones, los efectos adversos por la posición y el tipo de intervención que pueden presentar los pacientes. Por tanto, es imprescindible una detallada conducta anestésica. Representa un reto el manejo anestésico porque se requiere un abordaje multimodal en el pre-, intra- y posoperatorio; la seguridad de la vía aérea y una ventilación efectiva son las pautas en estas enfermedades(AU)

Introduction: Esophageal atresia is a rare congenital malformation, which consists of a defect in the development of the anterior intestine towards the esophagus and the trachea that occurs approximately in the fourth week of gestation. Objective: to describe the results of the anesthesiological intervention in a patient with EA and TEF, as well as the anesthetic considerations for the treatment of the entity. Case presentation: Term patient, female, white, birth weight 2880g, Apgar 8-9 at minute of life, diagnosed with esophageal atresia in the presence of respiratory distress at birth, excessive salivation with choking crisis at 6 hours of birth, and impossibility of inserting a nasogastric tube and confirmed by chest X-ray. She was announced for pediatric surgery and fistula repair was performed. The anesthetic considerations to be followed in the management of this case are exposed, related to: anesthetic drugs, volume replacement and the mechanical ventilation strategy. Favorable results were obtained. Conclusions: The urgent surgical resolution in newborns with esophageal atresia is important for their survival, to reduce complications, adverse effects due to the position and the type of intervention that patients may present, a detailed anesthetic conduct is essential. Anesthetic management represents a challenge because a multimodal approach is required pre, intra and postoperatively; airway safety and effective ventilation are the guidelines in these diseases(AU)

Fístula traqueoesofágica como complicación de la intubación endotraqueal prolongada / Tracheoesophageal fistula as a complication of prolonged endotracheal intubation

RESUMEN Introducción: La fístula traqueoesofágica consecutiva a intubación endotraqueal prolongada es una lesión grave con elevada morbimortalidad. El alto índice de sospecha, diagnóstico precoz, resolución de las complicaciones y un tratamiento quirúrgico definitivo son los pilares fundamentales en los cuales descansa su manejo correcto. Objetivo: Describir el comportamiento y manejo de la fístula traqueoesofágica en pacientes con intubación endotraqueal prolongada. Presentación del caso: Paciente de 34 años de edad que sufrió trauma craneoencefálico grave con necesidad de intubación endotraqueal prolongada. Su evolución fue favorable, con recuperación neurológica, pero presentaba tos incontrolable después de la deglución, aumento de las secreciones respiratorias y pérdida de 30 Kg de peso no resuelta, lo que motivó se le realizara tomografía computarizada multicorte dual sincronizada con el electrocardiograma, la que permitió de forma rápida y no invasiva, llegar al diagnóstico de la fístula traqueoesofágica. Conclusiones: La intubación endotraqueal prolongada constituye la causa principal de la aparición de la fístula traqueoesofágica. El mecanismo de producción fundamental fue la isquemia provocada por la compresión de las paredes posterior de la tráquea y anterior del esófago entre el manguito insuflado del tubo endotraqueal y la sonda nasogástrica. La tomografía computarizada multicorte dual sincronizada con el electrocardiograma permite realizar el diagnóstico de esta complicación.

ABSTRACT Introduction: Tracheoesophageal fistula following prolonged endotracheal intubation is a serious lesion with high morbidity and mortality. The high index of suspicion, early diagnosis, resolution of complications and definitive surgical treatment are the fundamental pillars on which its correct management rests. Objective: Describe the behavior and management of tracheoesophageal fistula in patients with prolonged endotracheal intubation. Case Presentation: A 34-year-old patient who suffered severe head trauma with the need of prolonged endotracheal intubation. His evolution was favorable, with neurological recovery, but he presented uncontrollable cough after swallowing, increased respiratory secretions and unsolved loss of 30 Kg of weight, which motivated to perform to him a dual multi-cut computed tomography synchronized with the electrocardiogram, which allowed quickly and non-invasively, to reach the diagnosis of tracheoesophageal fistula. Conclusions: Prolonged endotracheal intubation is the main cause of the appearance of tracheoesophageal fistula. The fundamental production mechanism was ischemia caused by compression of the posterior walls of the trachea and anterior walls of the esophagus between the inflated cuff of the endotracheal tube and the nasogastric tube. The dual multi-cut computed tomography synchronized with the electrocardiogram allows the diagnosis of this complication.

Advances in diagnosis and treatment of H-type tracheoesophageal fistula / 中华实用儿科临床杂志

Congenital H-type tracheoesophageal fistula (H-TEF) is a rare type of esophageal atresia.With the continuous development of ultrasound and magnetic resonance imaging (MRI) in the field of prenatal diagnosis in recent years, thoracoscopic surgery and endoscopic treatment, which are more minimally invasive than traditional open surgery, have also been carried out.Based on previous research reports, the diagnosis and treatment of congenital H-TEF was reviewed in this paper.

Clinical analysis of 10 cases of refractory tracheoesophageal fistula treated with novel double disc-shaped gastrointestinal occluder / 中华消化杂志

Objective:To evaluate the safety and clinical efficacy of the novel double disc-shaped gastrointestinal occluder (hereinafter referred to as occluder) in treatment of refractory tracheoesophageal fistula (TEF).Methods:From July 1, 2020 to January 31, 2021, 10 patients with refractory TEF treated with occluder at Department of Gastroenterology, the First Affiliated Hospital with Nanjing Medical University were collected. The patients′ clinical data such as gender, age, body mass index and fistula diameter were recorded. The success rate of operation, intraoperative and postoperative complications, operation time, postoperative hospital stay, efficacy of fistula closure and postoperative recovery were analyzed. The Karnofsky score and body mass index of patients 1 month and 3 months after operation were compared with those before operation for curative effect evaluation. Paired t test was used for statistical analysis. Results:Among the 10 TEF patients, there were 7 males and 3 females, the median age was 64.5 years old (ranged from 49.0 to 78.0 years old), the body mass index was (18.0±2.5) kg/m 2 and the diameter of the fistula was (1.2±0.6) cm. Occluder placement was successful in all patients. The operation time was (17.6±7.8) min (ranged from 7.0 to 30.0 min). Two cases had little bleeding during the operation, and there was no bleeding after the operation. The postoperative hospital stay was (5.9±4.0) d (ranged from 1.0 to 12.0 d). Among the 10 TEF patients, fistula of 5 patients were completely blocked, 4 cases were partially blocked and 1 case was ineffectively blocked, the effective rate of blocking was 9/10. One month follow-up after operation showed that the symptoms of choking and coughing during eating were significantly improved in 9 patients, and the symptoms of choking and coughing during eating were significantly improved in 1 patient after waist diameter of 12 mm occluder was replaced with the occluder of 15 mm. The 3-month follow-up after operation showed that the occluders were in the right place in 8 patients, the occluder was displaced in 1 patient and the occluder was removed and treated with enteral nutrition. One patient died due to the recurrence of esophageal cancer. The Karnofsky score of TEF patients 3 months after operation and the body mass index of TEF patients 1 month and 3 months after operation were higher than those before operation (70.0±34.0 vs. 46.0±10.7, (19.32±2.59) and (19.73±2.92) kg/m 2 vs. (18.03±2.50) kg/m 2), and the differences were statistically significant ( t=-3.09, -2.37 and -2.82, all P<0.05). Conclusions:Gastrointestinal occluder is safe and effective in the treatment of refractory TEF.

Application of electronic bronchoscope in 65 children with congential tracheoesophageal fistula during perioperative period / 中国小儿急救医学

Objective:To explore the value and risk of electronic bronchoscope applied in perioperative management of children with congential tracheoesophageal fistula.Methods:Sixty-five children with congential tracheoesophageal fistula performed electronic bronchoscope examination from September 2014 to November 2020 were enrolled in this study.The results of examination and complications were analyzed.Results:Sixty-three children with congenital tracheoesophageal fistula were diagnosed by electronic bronchoscopy.The diagnosis rate was 96.92%.Fifty-four children with congenital tracheoesophageal fistula were diagnosed by esophagography.The diagnosis rate was 91.53%.Sixty-one children with congenital tracheoesophageal fistula were diagnosed by multislice spiral computed tomography.The diagnosis rate was 93.85%.Airway anatomic abnormity was found in 27 children, including three cases of nasopharyngeal soft tissue collapse, 14 cases of laryngomalacia, five cases of tracheal stenosis, nine cases of tracheobronchomalacia, and nine cases of tracheobronchial and abnormal opening of the bronchus.The incidence was 41.54%.Three children with difficult ventilator weaning were related to tracheobronchial stenosis or tracheobronchomalacia.They were gradually weaning from ventilator after a long period of mechanical ventilation and treatment.Two children with transient decrease in oxygen saturation were noticed as complication.Conclusion:Electronic bronchoscopy is a safe and effective method for the diagnosis of congenital tracheoesophageal fistula and recurrence after operation.It is of great value to the airway management after operation by early detection of respiratory anatomic abnormity.

Atresia esofágica tipo III associada a ânus imperfurado: um relato de caso / Esophageal atresia type III associated to imperforate anus: a case report

Introdução: As malformações congênitas são defeitos que ocorrem durante o desenvolvimento embrio-fetal, principalmente entre a terceira e oitava semana de gestação, podendo ser suspeitado no período pré-natal. A atresia de esôfago com ou sem fístula traqueoesofágica pode estar associada a outras anomalias congênitas, como o ânus imperfurado, o qual faz parte uma síndrome denominada malformação anorretal. Objetivo: discutir o caso de um recém-nascido (RN) portador de atresia de esôfago tipo III e ânus imperfurado, bem como associar suas ocorrências simultâneas. Relato de caso: paciente do sexo masculino, advindo de uma gestação gemelar complicada por pré-eclâmpsia, apresentava ao nascimento ausência do reflexo de busca e sucção, bradicardia e cianose central. Foi diagnosticado com ânus imperfurado e atresia esofágica. Foram realizados cirurgia de Colostomia em Duas Bocas e tratamento cirúrgico da atresia de esôfago. O paciente ficou 48 dias em incubadora com intubação orotraqueal e ventilação mecânica por 26 dias. Resultado: a programação pós- alta indicada foi o acompanhamento com cirurgião pediátrico e neurocirurgião, tendo evoluído bem e aguardando anorretoplastia. Conclusão: o rápido diagnóstico é tão necessário, nesses casos, quanto as abordagens cirúrgicas. O apoio psicológico aos familiares é de extrema importância, pois visa a melhor aceitação da família frente ao caso, propiciando dessa forma, melhores prognóstico e tratamento do paciente.

Introduction: Congenital malformations are defects that occur during embryo-fetal development, especially between the third and eighth week of pregnancy, and may be suspected in the prenatal period. Esophageal atresia with or without tracheoesophageal fistula may be associated with other congenital anomalies, such as the imperforate anus, which is part of a syndrome called anorectal malformation. Objective: to discuss the case of a newborn (NB) with type III esophageal atresia and imperforate anus, as well as to associate its simultaneous occurrences. Case report: male patient, resulting from a twin pregnancy complicated by pre-eclampsia, had at birth the absence of the search and suction reflex, bradycardia and central cyanosis. He was diagnosed with imperforate anus and esophageal atresia. Double-barrel colostomy surgery and esophageal atresia surgery were performed. The patient spent 48 days in an incubator with orotracheal intubation and mechanical ventilation for 26 days. Results: the post-discharge schedule indicated was for follow-up with a pediatric surgeon and neurosurgeon. Patient evolved well and awaits anorectomy. Conclusion: rapid diagnosis is as necessary in these cases as surgical approaches. Psychological support to family members is extremely important, as it aims at better family acceptance in the case, thus providing better prognosis and treatment for the patient.

Asociación VACTERL con poliquistosis renal en un recién nacido: reporte de caso

Las malformaciones son causas importantes de mortalidad infantil, enfermedad crónica y discapacidad en muchos países, y ocasionan 3,2 millones de discapacidades al año. La asociación VACTERL involucra defectos vertebrales, atresia anal, fístula traqueoesofágica y displasia renal, así como anormalidades en las extremidades. Nuestro objetivo es describir las características generales de la asociación VACTERL y realizar un acercamiento a otros casos en la literatura. Nuestro caso trata de una recién nacida a las 35 semanas con grave dificultad respiratoria, que ingresa a la UCI neonatal por descompensación hemodinámica. Tiene un antecedente de poliquistosis renal bilateral a las 25 semanas dado por ecografía. En el examen físico se evidencia agenesia de órganos sexuales y ano imperforado, y en la radiografía se observa patrón atelectásico, cardiomegalia y posición dextrógira de la silueta cardiaca. La paciente fue diagnosticada con asociación VACTERL y ano imperforado. Sufrió un paro respiratorio y falleció luego de dos días.

Malformations are important causes of infant mortality, chronic disease and disability in many countries, causing 3.2 million disabilities per year. The VATERL association includes vertebral defects, anal atresia, tracheoesophageal fistula and renal dysplasia, as well as limb abnormalities. This case report aims to provide the general characteristics of the VACTERL association and discuss other cases found in the medical literature. This is the case of a female newborn delivered at 35 weeks of pregnancy with severe respiratory distress, who was admitted to the neonatal ICU due to hemodynamic decompensation. She had a history of bilateral polycystic kidney disease found by ultrasound at 25 weeks of pregnancy. A physical examination showed vaginal agenesis and imperforate anus. Atelectasis, cardiomegaly and dextroposition of the cardiac silhouette were observed in a radiography. The patient was diagnosed with VACTERL association and imperforate anus. She died 2 days after a respiratory arrest.

Primary repair: damage control surgery in esophageal trauma / El reparo primario: el control de daños en el trauma de esófago

Abstract Esophageal trauma is a rare but life-threatening event associated with high morbidity and mortality. An inadvertent esophageal perforation can rapidly contaminate the neck, mediastinum, pleural space, or abdominal cavity, resulting in sepsis or septic shock. Higher complications and mortality rates are commonly associated with adjacent organ injuries and/or delays in diagnosis or definitive management. This article aims to delineate the experience obtained by the Trauma and Emergency Surgery Group (CTE) of Cali, Colombia, on the surgical management of esophageal trauma following damage control principles. Esophageal injuries should always be suspected in thoracoabdominal or cervical trauma when the trajectory or mechanism suggests so. Hemodynamically stable patients should be radiologically evaluated before a surgical correction, ideally with computed tomography of the neck, chest, and abdomen. While hemodynamically unstable patients should be immediately transferred to the operating room for direct surgical control. A primary repair is the surgical management of choice in all esophageal injuries, along with endoscopic nasogastric tube placement and immediate postoperative care in the intensive care unit. We propose an easy-to-follow surgical management algorithm that sticks to the philosophy of "Less is Better" by avoiding esophagostomas.

Resumen El trauma esofágico es un evento poco frecuente pero potencialmente mortal. Una perforación esofágica inadvertida puede ocasionar la rápida contaminación del cuello, el mediastino, el espacio pleural o la cavidad abdominal, lo cual puede resultar en sepsis o choque séptico. Las complicaciones y la mortalidad aumentan con el retraso en el diagnóstico o manejo definitivo, y la presencia de lesiones asociadas. El objetivo del presente artículo es describir la experiencia adquirida por el grupo de cirugía de Trauma y Emergencias (CTE) de Cali, Colombia en el manejo del trauma de esófago de acuerdo con los principios de la cirugía de control de daños. Las lesiones esofágicas deben sospecharse en todo trauma toraco-abdominal o cervical en el que el mecanismo o la trayectoria de la lesión lo sugieran. El paciente hemodinámicamente estable se debe estudiar con imágenes diagnósticas antes de la corrección quirúrgica del defecto, idealmente por medio de tomografía computarizada del cuello, tórax y abdomen con contraste endovenoso. Mientras que en el paciente hemodinámicamente inestable se debe explorar y controlar la lesión. El reparo primario es el manejo quirúrgico de elección, con la previa colocación de una sonda nasogástrica y el seguimiento postoperatorio estricto en la unidad de cuidado intensivo. Se propone un algoritmo de manejo quirúrgico que resulta fácil de seguir y adopta la premisa "Menos es Mejor" evitando realizar derivaciones esofágicas.

Endoscopic features and management of acquired tracheoesophageal fistula caused by esophageal foreign bodies in children / 中华实用儿科临床杂志

Objective:To investigate the clinical characteristics, endoscopic features and management of acquired tracheoesophageal fistula (TEF) by esophageal foreign bodies in children.Methods:The clinical data and follow-up data of 21 children with acquired TEF who were treated in Children′s Hospital Affiliated to Zhengzhou University from January 2008 to January 2019 were retrospectively analyzed.Results:A total of 21 cases with esophageal foreign bodies were button batteries, irregular iron sheets, game coins, jujube seed, animal bone sheets, and fish thorn.The statistical results suggested that the cases of button batteries were 7 cases (33.33%), 4 cases of jujube pit (19.05%), 3 cases of irregular iron (14.29%) and 3 cases of animal bone (14.29%), 2 cases of game coin (9.52%), 2 cases of fish thorn (9.52%). All foreign bodies were removed by endoscopy.Esophageal perforation with TEF was discovered in 17 cases (80.95%) during the operation.Esophageal perforation with TEF was found in 4 cases (19.05%) within 2 week after the operation, and no death occurred.A total of 13 case fistula size ≤5 mm (61.90%), 4 case fistula size>5 mm and ≤10 mm (19.05%) and 4 case fistula size >10 mm (19.05%). The treatment methods included gastrointestinal decompression and nasojejunal nutrition tube support in 10 cases (47.61%), gastrostomy and jejunostomy in 4 cases (19.05%), surgical repair in 4 cases (19.05%) and endoscopic titanium clip suture in 3 cases (14.29%). Five cases (23.81%) were healed in 3 months, 6 cases (28.57%) in 5 months, 4 cases (19.05%) in 8 months, and 2 cases (9.52%) in 12 months.Conclusions:Acquired TEF in children are mostly caused by special foreign bodies embedded in the esophagus, and endoscopic management is effective for fistulas with less trauma.Appropriate operation and intervention should be taken as early as possible.

Pedicled latissimus dorsi myocutaneous flap for treatment of acquired tracheo-esophageal fistula combined with tracheocutaneous fistula: A case report / 中国胸心血管外科临床杂志

@#We reported a patient intubated for more than 30 d following brain injury, transferred to our department with tracheocutaneous fistula and a 2 cm fistula between the trachea and the esophagus. We performed tracheal resection and esophageal closure with a latissimus dorsi myocutaneous flap interposed between suture lines. The patient continued mechanical ventilation after surgery and the tracheotomy was achieved 14 d after the beginning of surgical treatment. The patient was started oral feeding and discharged on the 10 d after tracheotomy and referred to a neuromotor recovery clinic for treatment of post-traumatic sequelae.

Fístula traqueoesofágica en H en el período neonatal: dificultades en el diagnóstico y diferentes abordajes terapéuticos. Serie de casos / H-type tracheoesophageal fistula in neonatal period: Difficulties in diagnosis and different treatment approaches. A case series

La fístula traqueoesofágica congénita sin atresia esofágica asociada, conocida como tipo H, es una anomalía infrecuente. Se manifiesta con episodios de tos, ahogo y cianosis durante la alimentación y/o neumonía recurrente.Si bien los síntomas están usualmente presentes desde el nacimiento, el diagnóstico es difícil. La rareza de esta patología, los síntomas no específicos y las limitaciones en la demostración radiológica y endoscópica de la fístula contribuyen, a menudo, a la demora entre la presentación y la confirmación del diagnóstico.Se describen las manifestaciones clínicas, los métodos de evaluación y el tratamiento de 3 neonatos con esta patología, y se presentan recomendaciones para el diagnóstico a fin de evitar demoras innecesarias en el manejo de las fístulas en H.

Congenital tracheoesophageal fistula not associated with esophageal atresia, known as H-type fistula, is an uncommon anomaly. It presents with cough, choking, and cyanosis during feeding and/or recurrent pneumonia. Although symptoms are usually present from birth, diagnosis is difficult. The rarity of this disease, non-specific symptoms, and the limitations of radiological and endoscopic confirmation of the fistula often result in a delay between presentation and diagnosis confirmation. Here we describe the clinical manifestations, assessment methods, and management of 3 newborn infants with H-type tracheoesophageal fistula, together with diagnosis recommendations to prevent unnecessary delays in the management of this condition.

Delayed Referral and Anesthetic Management of Esophageal Atresia: A Challenge for Multidisciplinary Approach?

@#Esophageal atresia (EA) is one of congenital anomaly which needs early surgical intervention in most cases. The needs of early referral to tertiary healthcare in developing countries like Indonesia may be an issue. Airway management, adequate ventilation and concomitant comorbidities are serious challenges for the anesthesiologist. We reported a case of a 31 days old infant diagnosed as esophageal atresia and fistula in the tracheoesophageal with bilateral pneumonia and early onset of sepsis. Delayed of referral due to limited access to tertiary hospital. Preoperative optimization and stabilization to deal with respiratory problems and inadequate nutrition has done before the definitive surgery. Airway management to ensure adequate ventilation done by careful endotracheal placement. Thoracic epidural catheter was inserted to deliver adequate analgesia and reduce opioid requirements. We transferred the patient to the neonatal intensive care unit following 3 hours of uneventful surgery.

DSA-guided percutaneous radiologic gastrostomy for treatment of esophageal cancer with dysphagia / 中国介入影像与治疗学

Objective: To explore the therapeutic effect of DSA-guided percutaneous radiological gastrostomy (PRG) in patients with esophageal cancer with dysphagia. Methods: Data of 194 patients with esophageal cancer with dysphagia were retrospectively analyzed. The patients were divided into PRG group (enteral nutrition support via DSA-guided PRG, n=80) and non-PRG group (nutritional support through oral feeding after esophageal stent insertion, n=114). Body mass index (BMI), the serum levels of albumin, prealbumin, hemoglobin before and 1 month after operation, and the incidence of adverse reactions were compared between 2 groups. Results: There was no significant difference of BMI, albumin, prealbumin nor hemoglobin between 2 groups preoperation (all P>0.05). Albumin, prealbumin and hemoglobin 1 month after operation were lower than those preoperation in both groups (all P<0.05),but in PRG group were significantly higher than those in non-PRG group (all P<0.05). During the follow-up period, the incidences of aspiration pneumonia and tracheoesophageal fistula in PRG group were significantly lower than in non-PRG group (both P<0.05). Conclusion: DSA-guided PRG can improve nutritional status and reduce the incidences of aspiration pneumonia and tracheoesophageal fistula in patients with esophageal cancer with dysphagia.

Use of Hybrid Stent in Management of Complex Malignant Airway Stenosisand Fistulas / 中国肺癌杂志

BACKGROUND@#Airway stents has been widely used in airway stenosis and fistula, yet clinical date of airway stents in reestablishment a complex airway is insufficient. The aim of this study is to evaluate the efficacy and safety to combine the silicon stent and the metal stent in reestablishment a complex malignant airway.@*METHODS@#Patients with non-operable complex malignant airway stenosis and fistula were recruited in this study. Silicon Y stent combined with covered metal stent (Hybrid stent) were inserted to reestablishment the airway. Clinical outcomes and complications were observed over six months.@*RESULTS@#A total of 23 silicon Y stents and 25 covered metal stents were inserted in 23 patients. Nineteen of 23 (19/23, 82.6%) patients felt a immediately relieving of current symptoms. The mean duration of stents placement in patients was (153.43±9.14) days. The modified British Medical Research Council, Karnofsky Performance Status and Performance Status scale were improved significantly after stenting. A total of 12 patients living with stent at 6 months. Others dead of tumor progression. There were no death or immediate complications related to hybrid stenting implication.@*CONCLUSIONS@#Hybrid stenting proved to be useful and was well-tolerated in the management of complex malignant airway stenosis and fistula.

Clinical value of multi-slice spiral CT in the diagnosis of esophageal fistula after radiotherapy for esophageal cancer / 中国基层医药

Objective@#To investigate the application of multi-slice spiral CT in the diagnosis of esophageal fistula after esophageal cancer radiotherapy.@*Methods@#The subjects who were suspected to have esophageal fistula after radiotherapy for esophageal cancer admitted to the People's Hospital of Quzhou from January 2015 to February 2017 were randomly divided into A group and B group by means of lottery, with 15 cases in each group.The detection scheme of A group was multi-slice CT (MSCT), and the diagnosis of B group was performed by routine esophagography.The diagnostic accuracy of the two groups was observed, and the rate of missed diagnosis was compared.The amount of contrast agent such as gargle, mediastinal gas accumulation, and pneumothorax was observed.@*Results@#After the multi-slice spiral CT technique in A group, the missed diagnosis rate was 0%, which was significantly lower than that of B group (40%), the difference was statistically significant (χ2=8.097, P=0.016). In A group, the amount of contrast agent used in the diagnosis process were (32.4±4.5)mL, (25.1±3.2)mL, (20.5±2.4)mL, (19.5±12.3)mL in the diagnosis of effusion, pneumothorax, pneumonia and empyema, which were significantly better than those in B group (t=14.325, 15.652, 16.534, 15.973, P=0.025, 0.018, 0.013, 0.017).@*Conclusion@#Esophageal cancer complicated with esophageal fistula, especially small fistula is difficult to observe, resulting in missed diagnosis, the use of multi-slice spiral CT technology combined with appropriate post-treatment can greatly improve the accuracy of diagnosis, and thus timely treatment of patients, it is recommended for use.

Communicating Bronchopulmonary Foregut Malformation Type III with Pulmonary Sequestration Diagnosed in a Newborn: A Case Report

Communicating bronchopulmonary foregut malformation (CBPFM) is a communication between the respiratory and gastrointestinal tracts that can be difficult to differentiate from pulmonary sequestration or H-type tracheoesophageal fistula (TEF) because of the similarities in clinical features. A female neonate born at full term had been experiencing respiratory difficulty during feeding from the third day of life. The esophagography performed to rule out H-type TEF revealed that the esophageal bronchus directly communicated with the left lower lobe (LLL) of the lung. Lobectomy of the LLL, fistulectomy of the esophagobronchial fistula, and primary repair of the esophagus were performed. Finally, CBPFM type III with pulmonary sequestration was confirmed on the basis of the postoperative histopathological finding. We report the first newborn case of CBPFM type III with pulmonary sequestration in Korea.

Clinical value of multi-slice spiral CT in the diagnosis of esophageal fistula after radiotherapy for esophageal cancer / 中国基层医药

Objective To investigate the application of multi-slice spiral CT in the diagnosis of esophageal fistula after esophageal cancer radiotherapy.Methods The subjects who were suspected to have esophageal fistula after radiotherapy for esophageal cancer admitted to the People's Hospital of Quzhou from January 2015 to February 2017 were randomly divided into A group and B group by means of lottery,with 15 cases in each group.The detection scheme of A group was multi-slice CT (MSCT),and the diagnosis of B group was performed by routine esophagography.The diagnostic accuracy of the two groups was observed,and the rate of missed diagnosis was compared.The amount of contrast agent such as gargle,mediastinal gas accumulation,and pneumothorax was observed.Results After the multi -slice spiral CT technique in A group,the missed diagnosis rate was 0％,which was significandy lower than that of B group (40％),the difference was statistically significant (x2 =8.097,P =0.016).In A group,the amount of contrast agent used in the diagnosis process were (32.4 ± 4.5) mL,(25.1 ± 3.2) mL,(20.5 ± 2.4) mL,(19.5 ± 12.3) mL in the diagnosis of effusion,pneumothorax,pneumonia and empyema,which were significantly better than those in B group (t =14.325,15.652,16.534,15.973,P =0.025,0.018,0.013,0.017).Conclusion Esophageal cancer complicated with esophageal fistula,especially small fistula is difficult to observe,resulting in missed diagnosis,the use of multi-slice spiral CT technology combined with appropriate post-treatment can greatly improve the accuracy of diagnosis,and thus timely treatment of patients,it is recommended for use.

Cuidados de las fístulas traqueoesofágicas postintubación / Care of the post-intubation tracheoesophageal fistulae

RESUMEN Introducción: Las fístulas traqueoesofágicas posintubación son lesiones graves que presentan alta frecuencia de complicaciones y mortalidad. Objetivo: Actualizar el diagnóstico y tratamiento de pacientes con esta afección. Método: Se revisó la literatura en PUBMED/Medline e Infomed con las palabras clave: fístula, traqueoesofágica, fístula traqueoesofágica, postintubación y las correspondientes en inglés. Se revisaron las referencias bibliográficas de los artículos en busca de publicaciones relevantes. Se escogieron, preferentemente, trabajos prospectivos. Los informes de casos sólo se tomaron en cuenta cuando hacían referencia a alguna técnica novedosa. Desarrollo: Se encontraron 4260 artículos en Medline/Pubmed y 17 en Infomed. No se encontraron ensayos clínicos, metanálisis, ni revisiones sistemáticas. La mayoría de los artículos revisados hacen referencia a presentación de casos y algunos fueron estudios retrospectivos. Las presentaciones de casos se usaron solo si describían una técnica novedosa. Conclusiones: La intubación endotraqueal prolongada es la causa principal de FTEs. La patogenia se asocia con isquemia secundaria a compresión de las paredes traqueal posterior yesofágica anterior, entre el manguito insuflado del tubo endotraqueal y la sonda nasogástrica. El tratamiento conservador, generalmente, no cura la fístula, pero puede limitar la contaminación del árbol traqueobronquial y garantiza la nutrición. La derivación esofágica raramente está indicada, excepto cuando persiste entrada a la VR del contenido gastrointestinal. Actualmente, el tratamiento definitivo es la sutura esofágica y, en la mayoría de los casos, la resección y anastomosis traqueal(AU)

ABSTRACT Introduction: Post-intubation tracheoesophageal fistulae are severe lesions with high frequency of complication and high rate of mortality. Objective: To update the knowledge about the diagnosis and treatment of patients with this disease. Method: Literature review made in PUBMEDF/Medline and Infomed using the keywords: fistula, traqueoesophageal, tracheoesophageal fistula, and post-intubation in Spanish and English. References of articles were also reviewed to find out relevant publications. Prospective papers were particularly chosen. The case reports were only taken into account when they made reference to some novel technique. Results: In this search, 4260 articles were found in Medline/Pubmed and 17 in Infomed databases. No clinical assays, meta-analysis or systematic reviews were found. Most of the articles made reference to case reports and some to retrospective studies. The case reports were only used if they described a novel technique. Conclusions: Prolonged endotracheal intubation is the main cause of traqueoesophageal fistula. The pathogeny is associated to ischemia secondary to compression of posterior tracheal wall and anterior esophageal wall between the inflated cuff of the endotracheal tube and the nasogastric probe. In general, the conservative treatment does not cure the fistula but may restrict contamination of the tracheobronchial tree and guarantee nutrition. The esophageal shunt is rarely indicated, except when the gastrointestinal content continues entering into the VR. At present, the definitive treatment is the esophageal suturing and in most of cases, the resection and tracheal anastomosis(AU)

Clinical efficacy of stapler technique for repair of cervical tracheoesophageal fistula / 中国胸心血管外科临床杂志

@#Objective    To evaluate the clinical efficacy of fistula repair by stapler technique in patients with cervical tracheoesophageal fistula. Methods    Retrospective analysis of 8 patients with cervical tracheoesophageal fistula who accepted operative treatment in the Department of Thoracic Surgery, Lanzhou University Second Hospital from October 2014 to October 2016 was conducted. There were 5 males and 3 females at a mean age of 46.4±13.9 years ranging from 23 to 67 years. The fistula was induced by tracheal intubation in 4 patients, by esophageal foreign bodies in 2, by tracheal stent in 1 and by esophageal diverticulum in 1. The fistula was closed by stapler technique. The surgical effects were evaluated through Karnofsky performance score (KPS), image assessment, patient satisfaction score and assessment of improvement in feeding-induced bucking. Results    The operations were performed successfully with time of 117.5±6.6 min and intraoperative blood loss of 60.0±7.0 ml. After the operations, the patients did not suffer incision bleeding and infection, hoarseness, dyspnea, drinking-induced bucking, fistula relapse, tracheoesophageal stenosis or any other complications, and no death occurred during the perioperative period. The chest X-ray test was performed 1 week later showed that the pulmonary infection disappeared, and only 1 patient suffered from esophageal stenosis 1 year later. The postoperative KPS score was 90.0±7.0 points, which significantly improved in contrast to preoperation (P<0.01).   Postoperative pulmonary infection area reduced significantly (P<0.05), tracheoesophageal fistula disappeared, postoperative patients satisfaction rate was 90%, and assessment of feeding-induced bucking was excellent. Conclusion    Using stapler technique to repair cervical tracheoesophageal fistula is safe, easy and useful, with less operation time and postoperative complications.

Effects of angiogenic factors on lung development in rats with congenital esophageal atresia / 国际儿科学杂志

Objective To investigate the gene expression of Efnb2 and Ephb4 in the lung tissue of congenital esophageal atresia and tracheoesophageal fistula(EA-TEF) rat,and to explore the effect on lung development in EA rat.Methods Twenty-four female Wistar rats were randomly divided into experimental group(EATEF group)and control group(CON group)with 12 rats in each group.Adriamycin(ADR)-treated rats were established by intrapedtoneal injection of adriamycin at 1.75 mg / kg on day E7-9.The rats were sacrificed by caesarean on day 15 (E15),day 18 (El8) and day 21 (E21).The expression of Ephb4 and Efnb2 in fetal lung was detected by Q-PCR and immunohistochemistry.Results (1) It showed significantly higher mRNA expression levels of Efnb2 at the canalicular stage,which decreased and returned to pseudoglandular level at the sacular stage.The trend of Ephb4 mRNA and Efnb2 mRNA in the two groups was basically the same.The expression of Efnb2 mRNA in EA-TEF group(50.65 ± 12.65) was significantly higher than that in control group(23.63 ± 11.31) at the canalicular stage (P ＜ 0.05),but there was no statistical significance between the two groups at both pseudoglandular stage and sacular stage;The expression of Ephb4 mRNA in EA-TEF group (4.32 ± 2.88) was significantly higher than that in control group (1.01 ± 0.19) at the pseudoglandular stage (P ＜ 0.05),but there was no statistical significance between the two groups at both canalicular stage and sacular stage.(2)Efnb2 and Ephb4 proteins were expressed on the surface of vascular epithelium,alveolar and bronchial epithelium at different developmental stages,and there was no statistical significance in the distribution pattern.The expression of Efnb2 (162.70 ± 10.04) and Ephb4 (152.20 ± 12.32) in EA-TEF group was enhanced at the canalicular stage,while returned to normal level at the sacular stage.Conclusion The angiogenesis factor Efnb2 and its receptor Ephb4 can regulate the branching development of fetal lung tissue,which maybe a compensatory mechanism for pulmonary dysplasia in adriamycin-induced EA-TEF model.