RESUMO
Objective: To study the chemical constituents from the barks of Lannea coromandelica. Methods: The chemical constituents were isolated and purified by column chromatography on silica gel column. NMR spectra were used for structural identification. Results: Thirteen compounds were isolated and identified as quercetin (1), (2. S,3. S,4. R,10. E)-2-[(2'. R)-2'-hydroxytetracosanoyl amino]-10-octadecene-1,3,4-triol (2), aralia cerebroside (3), 5,5'-dibuthoxy-2,2'-bifuran (4), β-sitosteryl-3β-glucopyranoside-6'-. O-palmitate (5), β-sitosterol palmitate (6), myricadiol (7), protocatechuic acid (8), p-hydroxybenzoic acidethyl ester (9), isovanillin (10), trans-cinnamic acid (11), palmitic acid (12), and stearic acid (13). Conclusion: Compounds 2-13 are isolated from this plant for the first time. © 2014 Tianjin Press of Chinese Herbal Medicines.
RESUMO
Objective: Using ethanol as solvent, deionized water as anti-solvent, and HPMC as the surfactant, to prepare trans-cinnamic acid (TCA) micro powder by single factor analysis. The effects of five experimental parameters on the mean particle size (MPS) and morphology of TCA nanosuspension were investigated. Methods: Transmission electron microscope (TEM), laser granulometric analysis, Fourier transform infrared spectroscopy (FTIR), high performance liquid chromatography-mass spectrometry (LC-MS), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and dissolution were used to analyze the characteristic of micronized TCA nanosuspension. Results: The micronized TCA with an MPS of 130 nm was obtained under the optimum conditions. The dissolution rate of TCA nanosuspension was 1.67 times of raw drug. Conclusion: Using anti-solvent recrystallization to prepare micronized TCA can improve the solubility and dispersion of TCA nanosuspension in water, and they provide the basis for further formulation development.
RESUMO
Objective: To study the chemical constituents from the leaves of Acanthopanax evodiaefolius. Methods: The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were identified on the basis of their physicochemical properties and spectroscopic data. Results: Thirteen compounds were isolated from the methanol extract of A. evodiaefolius and their structures were identified as heptadecanoic acid (1), heptacosanol (2), trans-cinnamic acid (3), ursolic acid (4), oleanolic acid (5), betulinic acid (6), corosolic acid (7), apigenin (8), naringenin (9), maltol (10), syringic acid (11), stigmasterol (12), and daucosterol (13), respectively. Conclusion: Compounds 1-3 and 7-10 are obtained from the plans in genus Acanthopanax Miq. for the first time and all the compounds are obtained from A. evodiaefolius for the first time.