Website for families of non-breastfed children: development and validation of content and interface / Sitio de Internet para familias de niños no amamantados: desarrollo y validación de contenido y de interfaz / Website para família de crianças não amamentadas: desenvolvimento e validação de conteúdo e de interface

ABSTRACT Objectives: to develop and validate the content and interface of a guidance website to support families in promoting Food and Nutrition Security for children under six months who are not breastfed. Methods: methodological study, Knowledge Translation, in two stages of creation: 1) content and validation on the criterion of accuracy in a panel of experts; 2) interface and validation on the criteria of content, language, illustrations, layout, motivation, culture and applicability. Results: the "Milky Way" website is freely available: https://www.ufsm.br/pet/ciencia-da-computacao/alimentacao-lactea. The content was structured in a decision tree made up of types of milk: milk formula, whole cow's milk and powdered milk; and utensils: bottle, cup and measuring spoon. There were 46 illustrations to elucidate the content, facilitate understanding and engage the target population. The Content Validity Index was 0.91. Conclusions: the website is a validated technology with evidence-based written and pictorial content translated for use with families.

RESUMEN Objetivos: desarrollar y validar el contenido y la interfaz de sitio web orientador para apoyar a familias en la promoción de Seguridad Alimentaria y Nutricional de niños menores de seis meses no amamantadas. Métodos: estudio metodológico, de Traducción del Conocimiento, en dos etapas de creación: 1) contenido y validación según el criterio de precisión por panel de expertos; 2) interfaz y validación según los criterios contenido, lenguaje, ilustraciones, maquetación, motivación, cultura y aplicabilidad. Resultados: el sitio "Vía Láctea" es de libre acceso: https://www.ufsm.br/pet/ciencia-da-computacao/alimentacao-lactea. El contenido se estructuró en un árbol de decisión compuesto por tipos de leche: fórmula láctea, leche entera de vaca y leche en polvo; y utensilios: biberón, taza y cuchara dosificadora. Hay 46 ilustraciones para elucidar el contenido, facilitar la comprensión y atraer a la población objeto. El índice de validez del contenido fue de 0,91. Conclusiones: el sitio web es una tecnología validada con contenidos escritos y visuales basados en pruebas y traducidos para su uso con las familias.

RESUMO Objetivos: desenvolver e validar o conteúdo e a interface de website orientativo para apoiar a família na promoção de Segurança Alimentar e Nutricional de crianças menores de seis meses não amamentadas. Métodos: estudo metodológico, de Tradução do Conhecimento, em duas etapas de criação: 1) conteúdo e validação no critério precisão em painel de especialistas; 2) interface e validação nos critérios conteúdo, linguagem, ilustrações, layout, motivação, cultura e aplicabilidade. Resultados: o website "Via láctea" está disponível em livre acesso: https://www.ufsm.br/pet/ciencia-da-computacao/alimentacao-lactea. O conteúdo foi estruturado em árvore de decisão composta por tipo de leite: fórmula láctea, leite de vaca integral e em pó; e utensílios: mamadeira, copinho e colher dosadora. Constam 46 ilustrações para elucidar conteúdo, facilitar compreensão e engajar população-alvo. O Índice de Validade do Conteúdo foi de 0,91. Conclusões: o website é uma tecnologia validada com conteúdo escrito e imagético baseado em evidências e traduzido para uso com famílias.

The fruits of innovation and transformation will blossom and bear fruit on the land of China / 中华骨科杂志

In the new journey of building a modern socialist country in an all-round way, China is gradually entering the ranks of innovative countries. The national emphasis on scientific and technological innovation and transformation and the policy guidance have inspired the unprecedented enthusiasm and confidence of Chinese orthopaedic surgeons for innovation and transformation. After decades of unremitting efforts of orthopaedics predecessors, Chinese orthopaedics, as the new force of scientific and technological innovation, has been developing towards the direction of digitalization, personalized, minimally invasive, precise and intelligent, but some problems have also been exposed. We should strengthen the main position of independent innovation of orthopedics new technology, materials and instruments, implement the strategy of combining "import" with China's specific national conditions, and use Chinese and western, strive to solve the problem of transformation of scientific research results, accelerate the process of localization replacement, so that the innovation transformation results in the land of China.

Video clip for learning the physiology of lactation: evaluation by the family support network for breastfeeding women / Videoclip para aprender la fisiología de la lactancia: evaluación realizada por la red de apoyo familiar para mujeres en lactancia / Videoclipe para aprendizagem da fisiologia da lactação: avaliação pela rede de apoio familiar às lactantes

ABSTRACT Objective: to evaluate the adequacy of using a care-educational technology with video clips for learning the physiology of lactation by the family support network for breastfeeding women. Method: a methodological study guided by the Knowledge Translation in Action Model. The collection procedure was carried out from July to September 2022 in the city of Santa Cruz do Sul, state of Rio Grande do Sul, Brazil. After the childcare consultation, each puerperal woman indicated one or more members of her support network to participate in the research. In face-to-face interviews, 52 participants answered the following instruments: Assistive Technology Assessment and Face Validation of Educational Technologies in Health. Normality of the variables was verified using the Kolmogorov-Smirnov test. The quantitative variables with normal distribution were described by mean and standard deviation. Face Validity Index and Cronbach's Alpha were calculated. Results: the video clip was evaluated as adequate (1.75) in all attributes: Interactivity (1.75), Objectivity (2.00), Relevance and efficacy (2.00) and Clarity (2.00). Face validity was excellent (0.969). Both instruments obtained Cronbach's Alpha values of 0.883 and 0.852, respectively, indicating reliability in this population. Conclusion: the video clip for learning the physiology of lactation is suitable for use by the family support network for breastfeeding mothers.

RESUMEN Objetivo: evaluar lo adecuado de utilizar una tecnología de atención-educativa del tipo videoclip para aprender la fisiología de la lactancia con la red de apoyo familiar para mujeres en lactancia. Método: estudio metodológico guiado por el Modelo de Traducción del Conocimiento en Acción. Los datos se recolectaron entre julio y septiembre de 2022 en la ciudad de Santa Cruz do Sul, estado do Río Grande do Sul, Brasil. Después de la consulta de puericultura, cada puérpera indicó al menos un integrante de su red de apoyo para que participara de la investigación. En sendas entrevistas presenciales, 52 participantes respondieron los siguientes instrumentos: Evaluación de Tecnología de Asistencia y Validación de la Apariencia de Tecnologías Educativas en Salud. La normalidad de las variables se verificó con la prueba de Kolmogorov-Smirnov. Las variables cuantitativas con distribución normal se describieron con valores medios y desviaciones estándar. Se calcularon el Índice de Validez de la Apariencia y el coeficiente Alpha de Cronbach. Resultados: el videoclip fue evaluado como adecuado (1,75) en todos los atributos: Interactividad (1,75), Objetividad (2,00), Relevancia y eficacia (2,00) y Claridad (2,00). La validez de la apariencia fue excelente (0,969). Ambos instrumentos obtuvieron coeficientes Alpha de Cronbach de 0,883 y 0,852 respectivamente, indicando confiabilidad en esta población. Conclusión: el videoclip para aprender la fisiología de la lactancia es adecuado para ser usado por la red de apoyo familiar para mujeres en lactancia.

RESUMO Objetivo: Avaliar a adequação do uso da tecnologia cuidativo-educacional, do tipo videoclipe, para aprendizagem da fisiologia da lactação pela rede de apoio familiar às lactantes. Método: Estudo metodológico, guiado pelo Modelo de Tradução do Conhecimento em Ação. A coleta foi desenvolvida na cidade de Santa Cruz do Sul, no Estado do Rio Grande do Sul, Brasil, no período de julho a setembro de 2022. Após a consulta de puericultura, a puérpera indicou um ou mais membros de sua rede de apoio para participar da pesquisa. Em entrevista presencial, 52 participantes responderam os instrumentos: Avaliação de Tecnologia Assistiva e Validação de Aparência de Tecnologias Educacionais em Saúde. A normalidade das variáveis foi verificada com o teste de Kolmogorov Smirnov. As variáveis quantitativas com distribuição normal foram descritas pela média e o desvio padrão. Foram calculados o Índice de Validade de Aparência e o Alpha de Cronbach. Resultados: O videoclipe foi avaliado como adequado (1,75) em todos os atributos interatividade (1,75), objetividade (2,00), relevância e eficácia (2,00) e clareza (2,00). A validade de aparência foi excelente (0,969). Ambos os instrumentos obtiveram Alpha de Cronbach, 0,883 e 0,852 respectivamente, apontando a confiabilidade nesta população. Conclusão: O videoclipe para aprendizagem da fisiologia da lactação está adequado ao uso pela rede de apoio familiar às lactantes.

Methodological quality of network meta-analysis in dentistry: a meta-research

Abstract This meta-research aimed to provide an overview of the methodological quality and risk of bias of network meta-analyses (NMA) in dentistry. Searches for NMA of randomized clinical trials with clinical outcomes in dentistry were performed in databases up to January 2022. Two reviewers independently screened titles/abstracts, selected full texts, and extracted the data. The adherence to PRISMA-NMA reporting guideline, the AMSTAR-2 methodological quality tool, and the ROBIS risk of bias tool were assessed in the studies. Correlation between the PRISMA-NMA adherence and the AMSTAR-2 and ROBIS results was also investigated. Sixty-two NMA studies were included and presented varied methodological quality. According to AMSTAR-2, half of the NMA presented moderate quality (n = 32; 51.6%). The adherence to PRISMA-NMA also varied. Only 36 studies (58.1%) prospectively registered the protocol. Other issues lacking of reporting were data related were data related to the NMA geometry and the assessment of results consistency, and the evaluation of risk of bias across the studies. ROBIS assessment showed a high risk of bias mainly for domains 1 (study eligibility criteria) and 2 (identification and selection of studies). Correlation coefficients between the PRISMA-NMA adherence and the AMSTAR-2 and ROBIS results showed moderate correlation (rho < 0.6). Overall, NMA studies in dentistry were of moderate quality and at high risk of bias in several domains, especially study selection. Future reviews should be better planned and conducted and have higher compliance with reporting and quality assessment tools.

Fourth Generation Evaluation as a path for Knowledge Translation in mental health / La Evaluación de Cuarta Generación como camino para la Traslación del Conocimiento en salud mental / Avaliação de Quarta Geração enquanto percurso para a Translação do Conhecimento na saúde mental

ABSTRACT Objective: To discuss the use of the Fourth Generation Evaluation methodology as a powerful theoretical-methodological path for the implementation of Knowledge Translation in child and adolescent mental health. Method: It comprises the description of the stages and fieldwork of a research that evaluated mental health practices aimed at adolescents in a Child and Adolescent Psychosocial Care Center, between August and December 2018, with the health care team. Results: Using strategies to involve workers in all stages, a dialectical construction of knowledge, the adaptation of the path to the field - with the implementation of interventions suggested by the participants - and the research path itself, in its condition of product/result, enable the interface with Knowledge Translation. Final considerations: The characteristics discussed allow to suggest using the Evaluation as an alternative to the implementation of Translation, especially in the field of mental health.

RESUMEN Objetivo: Discutir el uso de la metodología de Evaluación de Cuarta Generación como un camino teórico-metodológico para la implementación de la Traducción del Conocimiento en salud mental del niño y del adolescente. Método: Comprende la descripción de las etapas y el trabajo de campo de una investigación que evaluó las prácticas de salud mental dirigidas a adolescentes en un Centro de Atención Psicosocial de Niños y Adolescentes, entre agosto y diciembre de 2018, con el equipo. Resultados: Utilizar estrategias para involucrar a los trabajadores en las etapas, construir conocimiento dialécticamente, la adecuación del camino al campo - implementar intervenciones sugeridas por los participantes- y el camino de la investigación, en su condición de producto/resultado, habilite la interfaz con Traducción del Conocimiento. Consideraciones finales: Las características discutidas permiten sugerir el uso de la Evaluación como una alternativa a la implementación de la Traducción, especialmente en el campo de la salud mental.

RESUMO Objetivo: Discutir o uso da metodologia da Avaliação de Quarta Geração como um percurso teórico-metodológico potente para implementação da Translação do Conhecimento na saúde mental infantojuvenil. Método: Compreende a descrição das etapas e do trabalho de campo de uma pesquisa que avaliou as práticas em saúde mental voltadas aos adolescentes em um Centro de Atenção Psicossocial infantojuvenil, entre agosto e dezembro de 2018, com a equipe assistencial do serviço. Resultados: A utilização de estratégias para envolver os trabalhadores em todas as etapas, a construção do conhecimento de maneira dialética, a adaptação do percurso ao campo - com a realização de intervenções sugeridas pelos participantes - e o próprio percurso da pesquisa,em sua condição de produto/resultado, viabilizam a interface com a Translação do Conhecimento. Considerações finais: As características discutidas possibilitam sugerir que se utilize a Avaliação como alternativa à implementação da Translação, sobretudo no campo da saúde mental.

Cost-related variables in the public purchase of dental materials for endodontic application: 10-year analysis

Aim: This study analyzed public procurements for different endodontic materials used in the Brazilian public health system and evaluated the variables related to their cost. Methods: A time-series study was performed by screening materials for endodontic application in the public Brazilian Databank of Healthcare Prices from 2010 to 2019. Data were categorized according to material composition and clinical application. The collated variables were used in a multiple linear regression model to predict the impact of unit price in procurement processes. Results: A total of 5,973 procurement processes (1,524,693 items) were evaluated. Calcium hydroxides were found in 79% of the observations (4,669 processes). Prices drop each year by US$1.87 while MTAs and epoxy resins are increasingly purchased at higher prices (US$50.87; US$67.69, respectively). The microregion, the procurement modality, and the type of institution had no influence on unit prices in the adjusted model (p > 0.05). Conclusions: Calcium hydroxide-based materials were the cheapest and most frequently purchased endodontic materials in the public health care system. Novel formulations are being implemented into clinical practice over time and their cost may be a barrier to the broad application of materials such as MTAs, despite their effectiveness

Nurse-led translational research: An emerging field in multidisciplinary research

Translational research is well-known concept in healthcare still nurse-led translational research is an emerging area of multidisciplinary nursing research. This study intends to offer an in-depth look at translational research and the process for its applications in nursing education, practice, and research. Nurses, educators, researchers, and policymakers will better understand nurse scientists’ expanded role in education and clinical practice. This paper will assist the nurse educators, researchers to stay informed of translational research and its nursing impact. To develop a narrative synthesis study, a detailed systematic literature review was conducted in Pub Med, Web of Sciences, Scopus, ProQuest, Ovid using the keywords “translational research,” “nursing,” “implementation science,” “barriers in translational research” themes generated in selected paper are discussed in detail in this paper. 32 articles were found to be relevant to discuss the concepts of translational research in nursing practices. In contrast to basic research, translational research works cooperatively to assess the efficacy of evidence from the bench to the bed, from one realm to another. It requires the transparent method for dealing with roadblocks, such as following evidence-based recommendations while assessing evidence, so that policymakers can determine whether to embrace them for the development of the health-care system. Nurse-led translational research under the direction of a nurse scientist has the potential to advance nursing excellence in both clinical and community health settings.

Significance of a neglected tropical disease: lessons from a paradigmatic case of 'success in translation'

In a previous publication, I stressed the fundamental importance of research for improving health using as an example the control of Chagas disease in the Americas.(1) For that purpose, I analysed the major scientific breakthroughs and public health events from the 1909 discovery of Chagas disease and its causative pathogen, Trypanosoma cruzi, by Carlos Chagas,(2) through the successful control of its transmission by insect vectors in large regions of the Southern Cone countries in the 90s.(3) In the twenty years since that publication, Brazil and Latin American countries had to cope with a number of serious public health threats, old and new: (i) recrudescence of well-known diseases, such as dengue and yellow fever; (ii) emergence of viral diseases that had been restricted to other continents (Zika, Chikungunya); (iii) new epidemics (H1N1) or (iv) pandemics (COVID-19). Are there still some lessons from that success story against a neglected disease of the 90s that would be relevant today in the context of these recent challenges?

Research on the clinical and translational science awards of The National Institutes of Health / 中华医学科研管理杂志

Translational medicine is a more effective and efficient way to improve the investment return on bioscience and provide equitable access to high—quality healthcare.Recognizing the need for a new impetus to spur clinical and translational research,the National Institutes of Health established the Clinical and Translational Science Awards Program.

Pesquisa Translacional: uma interpretação / Translational research: an interpretation

A Pesquisa Translacional (TR) parece estar se tornando o principal mote da pesquisa em saúde neste início de século. Nascida nos Estados Unidos da América (EUA), vem se disseminando rapidamente pelo mundo desenvolvido bem como pela periferia. O artigo discute os principais tópicos relativos a ela. A sua definição e o seu escopo, as razões de ter nascido nos EUA e o porquê de ter nascido neste século. Debate as relações entre a TR e os fundamentos da política científica nos EUA, estabelecidos ao final da Segunda Grande Guerra. Interpreta a demanda de uma indústria farmacêutica poderosa e em crise, associada a dificuldades de outputs científicos em quantidade adequada para atendê-la como um móvel suficiente para explicar a intervenção do governo norte-americano na pesquisa biomédica através do NIH. Entende que é difícil prognosticar o futuro da TR, mas que não se trata de uma proposição sustentada em terreno teórico-conceitual sólido. Tematiza também a oportunidade e as possibilidades da TR em países com sistemas nacionais de inovação imaturos, como é o caso do Brasil. Finalmente, propõe que a existência de um sistema universal de saúde seja a principal ferramenta organizadora das respostas possíveis da pesquisa em saúde às demandas de inovação por parte da sociedade.

Translational Research (TR) appears to be developing into the key health research issue of the beginning of this century. Initially proposed in the United States, TR is spread rapidly throughout both the developed and the developing world. This article discusses the main topics it covers, such as its definition and scope and the reasons why it has emerged in the USA and in this century. It examines the relationship between TR and the basic principles of US scientific policy established at the end of World War II. It sees the demands of a mighty pharmaceutical industry, currently facing a major crisis, linked to scientific genomic and post-genomic output impairments in terms of real innovative products and processes as being the explanation for US government intervention in biomedical research via the NIH. It realizes that it is not easy to predict the future of TR and suggests that it is not sustained by a solid conceptual and theoretical framework. It also discusses the opportunities and possibilities of TR in countries with nascent national innovative systems, such as Brazil. Lastly, it suggests that the existence of a universal health system can be an important tool to provide potential research answers tin health for the demands of innovation on the part of society.