Adaptação cultural do questionário de avaliação de resultados em blefaroplastia: Blepharoplasty Outcomes Evaluation / Cultural adaptation of the blepharoplasty outcomes evaluation questionnarie: Blepharoplasty Outcomes Evaluation

Introdução: O emprego de questionários de qualidade de vida tem se mostrado muito útil no sentido de dar maior objetividade à avaliação de resultados de tratamentos. A internacionalização desses instrumentos, por sua vez, permite a comparação interpopulacional, mas requer uma metodologia específica, a fim de não causar distorções devido a falhas na tradução ou a diferenças culturais. O questionário Blepharoplasty Outcomes Evaluation, de língua inglesa, é uma ferramenta de simples aplicação, com perguntas objetivas com boa aplicação para esse fim. O questionário já foi testado em relação à sua confiabilidade, validade e capacidade de resposta. Métodos: Realizada tradução e adaptação cultural para a língua portuguesa, segundo a metodologia proposta por Beaton et al., na qual existem 5 estágios. Estágio 1 - tradução por meio de dois tradutores nativos de língua portuguesa. Estágio 2 - confecção de versão de síntese. Estágio 3 - tradução reversa por dois tradutores nativos de língua inglesa. Estágio 4 - revisão por um comitê avaliador. Estágio 5 - aplicação a uma população de 20 pessoas. Resultados: A partir do comitê avaliador, não houve problemas de compreensão para a população final. Conclusão: O questionário foi traduzido e adaptado com sucesso.

Introduction: The use of quality of life questionnaires has proved to be very useful in giving greater objectivity to evaluating treatment results. The internationalization of these instruments, in turn, allows for interpopulation comparison but requires a specific methodology in order not to cause distortions due to failures in translation or cultural differences. The Blepharoplasty Outcomes Evaluation questionnaire, in English, is a simple application tool with objective questions with a good application for this purpose. The questionnaire has already been tested for reliability, validity and responsiveness. Methods: According to the methodology proposed by Beaton et al., translation and cultural adaptation into Portuguese was performed with 5 stages. Stage 1 - translation by two native Portuguese-speaking translators. Stage 2 - preparation of the synthesis version. Stage 3 - reverse translation by two native English-speaking translators. Stage 4 - review by an evaluation committee. Stage 5 - application to a population of 20 people. Results: There were no comprehension problems for the final population from the evaluation committee. Conclusion: The questionnaire was successfully translated and adapted.

Vítimas com traumatismo cranioencefálico na sala de emergência e fator associado à permanência no setor / Víctimas con traumatismo craneoencefálico en urgencias y factor asociado a permanencia en el sector / Victims with traumatic brain injury in the emergency room and factor associated with permanence in the sector

Objetivo: analisar a evolução das vítimas de traumatismo cranioencefálico contuso na sala de emergência e identificar fatores independentes para tempo de permanência nesse serviço. Método: coorte prospectiva que incluiu todas as vítimas que atenderam aos critérios de elegibilidade e foram admitidas entre julho e dezembro de 2017 em hospital referência para trauma. Foi aplicado o Rapid Emergency Medicine Score para identificar a evolução das vítimas até 6 horas após admissão e aplicadas estatísticas descritivas e análise bivariada. Resultados: entre a admissão e 2 horas, foram observadas mudanças desfavoráveis em 35,1% das vítimas, entre 2-4 horas em 13,6% e entre 4-6 horas, em 42,8%; foi observada melhora entre 27% e 28,6% da casuística. Suporte hemodinâmico foi fator independente para tempo de permanência. Conclusão: a evolução desfavorável foi mais frequente entre a admissão e 2 horas e após 4 horas. A maior permanência na sala de emergência ocorreu em vítimas com suporte hemodinâmico.

Objetivo: analizar la evolución de las víctimas de traumatismo craneoencefálico contundente en la sala de urgencias e identificar factores independientes para la duración de la estancia en este servicio. Método: cohorte prospectiva que incluyó a todas las víctimas que cumplieron con los criterios de elegibilidad y estuvieron ingresadas entre julio y diciembre de 2017 en un hospital de referencia por traumatismo. Se aplicó el Rapid Emergency Medicine Score para identificar la evolución de las víctimas hasta 6 horas después del ingreso y se aplicó estadística descriptiva y análisis bivariado. Resultados: entre el ingreso y 2 horas, se observaron cambios desfavorables en 35,1% de las víctimas, entre 2-4 horas en 13,6% y entre 4-6 horas, en 42,8%; se observó mejoría entre el 27% y el 28,6% de la muestra. El soporte hemodinámico fue un factor independiente para la duración de la estancia. Conclusión: la evolución desfavorable fue más frecuente entre el ingreso y 2 horas y después de 4 horas. La estancia más larga en la sala de urgencias ocurrió en víctimas con soporte hemodinámico.

Objective: analyzing the evolution of victims of blunt traumatic brain injury in the emergency room and identifying independent factors for length of stay in this service. Method: a prospective cohort that included all victims who met the eligibility criteria and were admitted between July and December 2017 in a reference hospital for trauma. The Rapid Emergency Medicine Score was applied to identify the evolution of the victims up to 6 hours after admission and descriptive statistics and bivariate analysis were applied. Results: between admission and 2 hours, unfavorable changes were observed in 35.1% of the victims, between 2-4 hours in 13.6% and between 4-6 hours, in 42.8%; improvement was observed between 27% and 28.6% of the sample. Hemodynamic support was an independent factor for length of stay. Conclusion: unfavorable evolution was more frequent between admission and 2 hours and after 4 hours. The longest stay in the emergency room occurred in victims with hemodynamic support.

Pulmonary balloon angioplasty for patients with chronic thromboembolic pulmonary hypertension accompanying with progressed pulmonary hypertension after pulmonary endarterectomy / 中国胸心血管外科临床杂志

@#Objective    To describe the effect of sequential pulmonary balloon angioplasty for patients with chronic thromboembolic pulmonary hypertension, who was accompanied with progressed pulmonary hypertension after pulmonary endarterectomy surgeries. Methods    From 2014 to December 2017, 7 patients were treated with a combination therapy of pulmonary endarterectomy and sequential pulmonary balloon angioplasty. There were 1 male and 6 females at age of 58 (43–59) years. A follow-up period of more than 1 year was accomplished. The result of right sided heart catheterization and ultrasonic cardiogram between and after the pulmonary endarterectomy or balloon angioplasty was collected. Results    Seven patients were treated with a combination of pulmonary endarterectomy and sequential pulmonary balloon angioplasty, which included 1 patient of single pulmonary balloon angioplasty and 6 patients of multiple pulmonary balloon angioplasties. The balloon dilation times was 2 (2–6), and the number of segments during each single balloon dilatation was 3–5, compared with the first clinical results before  the first balloon dilation, systolic pulmonary artery pressure [53 (47–75) mm Hg vs. 45 (40–54) mm Hg, P=0.042), mean pulmonaryartery pressure [38 (29–47) mm Hg vs. 29 (25–39) mm Hg, P=0.043], N terminal-B type natriuretic peptide [1 872 (1 598–2 898) pg/ml vs. 164 (72–334) pg/ml, P=0.018] improved significantly after the last balloon angioplasty. Heart function classification (NYHA) of all the 7 patients were recovered to Ⅰ-Ⅱclasses (P<0.05). Conclusion    Sequential pulmonary balloon angioplasty after pulmonary endarterectomy can further reduce the patient's right heart after load, improve the heart function for patients with progressed pulmonary hypertension after pulmonary endarterectomy surgeries.

Desarrollo y validación de escala multimodal para resultados de tratamiento en trastornos por uso de sustancias / Development and validation of multimodal scale for results of treatment in disorders caused by substance use / Desenvolvimento e validação de escada multimodal para resultados de tratamento em trastornos por uso de substancias

Resumen Objetivo: Describir el proceso de desarrollo y validación de un instrumento creado para la evaluación de los resultados de tratamiento en los trastornos por uso de sustancias. Materiales y métodos: Este fue llevado a cabo en tres fases. Fase 1: revisión de la literatura en las principales bases de datos de ciencias de la salud sobre escalas o instrumentos para evaluación de resultados de tratamiento en trastornos por uso de sustancias. Fase 2: desarrollo de un instrumento de novo y validación por expertos mediante técnica Delphi modificada a 2 fases. Fase 3: estudio de validación clínica en el que participaron 100 usuarios de una institución pública. Resultados: La escala de evaluación de tratamiento multimodal (EETM) obtuvo, luego de su análisis de contenido, unos resultados apropiados en términos de pertinencia y relevancia; adicionalmente mostró coeficientes de alpha de Cronbach entre 0,799 y 0,963 y similitudes entre los resultados del evaluador y el paciente. Conclusiones: Se concluye que la EETM demostró ser un instrumento válido para la evaluación de los resultados de tratamiento en instituciones con intervenciones integrales en los trastornos por uso de sustancias y durante el período de internamiento.

Abstract Objective: to describe the process of development and validation of an instrument created for the evaluation of treatment results in disorders caused by substance use. Materials and methods: The study was carried out in three phases. Phase 1: review of the literature in the main health science databases about scales or instruments for evaluation of treatment results in disorders caused by substance use; Phase 2: de novo instrument development and validation by experts using a modified 2-phase Delphi technique; Phase 3: clinical validation study involving 100 users of a public institution. Results: The "Escala de evaluación de tratamiento multimodal" (EETM), after its content analysis, obtained appropriate results in terms of pertinence and relevance. Additionally, it showed Cronbach's Alpha coefficients between 0.799 and 0.963 and similarities between the evaluator and the patient results. Conclusions: It was concluded that the EETM proved to be a valid instrument for the evaluation of treatment results in institutions with comprehensive interventions in disorders caused by substance use and during the admission period.

Resumo Objetivo: Descrever o processo de desenvolvimento e validação de um instrumento criado para a avaliação dos resultados de tratamento nos transtornos por uso de sustâncias. Materiais e métodos: Este foi levado a cabo em três fases. Fase 1: revisão da literatura nas principais bases de dados de ciências da saúde sobre escadas ou instrumentos para avaliação de resultados de tratamento em transtornos por uso de sustâncias. Fase 2: desenvolvimento de um instrumento de novo e validação por expertos mediante técnica Delphi modificada a 2 fases. Fase 3: estudo de validação clínica no que participaram 100 usuários de uma instituição pública. Resultados: A escada de avaliação de tratamento multimodal (EETM) obteve, logo de sua analise de conteúdo, uns resultados apropriados em termos de pertinência e relevância; adicionalmente mostrou coeficientes de alpha de Cronbach entre 0,799 e 0,963 e similitudes entre os resultados do avaliador e o paciente. Conclusões: Conclui se que a EETM demonstrou ser um instrumento válido para a avaliação dos resultados de tratamento em instituições com intervenções integrais nos transtornos por uso de sustâncias e durante o período de internamento.

Lymphoepithelial cyst on the tongue: case report at unusual location / Cisto linfoepitelial em língua: relato de caso em localização incomum

ABSTRACT Oral lymphoepithelial cyst (OLEC) is an uncommon lesion that develops in oral lymphoid tissue. The aim of the present study was to report a clinical case of OLEC in the tongue. A 22-year-old patient presented a nodular lesion, yellowish, with a softened consistency, measuring 0.5 cm in the ventral surface of the tongue. Under the clinical hypotheses of mucocele and OLEC, excisional biopsy was performed. The histopathological examination revealed a cystic lesion covered by a parakeratinized stratified squamous epithelium, which presented in its fibrous capsule a prominent lymphoid tissue. Based on the definitive diagnosis, surgical excision of the lesion was performed.

RESUMO O cisto linfoepitelial oral (CLEO) é uma lesão incomum que se desenvolve no tecido linfoide oral. O objetivo do presente trabalho foi relatar um caso clínico de CLEO na língua. Paciente de 22 anos de idade exibia uma lesão nodular, de coloração amarelada e consistência amolecida, medindo 0,5 cm na região ventral de língua. Sob as hipóteses clínicas de mucocele e CLEO, foi realizada biópsia excisional. O exame histopatológico revelou lesão cística revestida por epitélio escamoso estratificado paraceratinizado, que apresentava em sua cápsula fibrosa tecido linfoide proeminente. Com base no diagnóstico definitivo, foi realizada a excisão cirúrgica da lesão.

Functional result relating to the positioning of the graft in anterior cruciate ligament reconstruction / Resultado funcional relacionado ao posicionamento do enxerto na reconstrução do ligamento cruzado anterior

To ascertain the coronal angles for the femoral and tibial tunnels that provide the best postoperative result from anterior cruciate ligament (ACL) reconstruction surgery, through assessing the variables of the IKDC and Lysholm-Tegner questionnaires and the hop test. METHODS: Sixteen patients with a single unilateral ACL injury who underwent this surgery between 24 and 36 months earlier were evaluated. They were divided into four groups in which the tibial and femoral tunnel angles were greater than or less than 65° in the coronal plane. RESULTS: The results demonstrated that a more vertical angle for the tibial tunnel (72°) and a more horizontal angle for the femoral tunnel (60°), with valgus alignment of 12° correlated with the best values for the variables studied. This may indicate that the long-term results from this surgery are excellent. CONCLUSION: A more horizontal femoral angle and a more vertical tibial angle produced better assessments in the tests that were applied and in the functional results evaluated...

Averiguar qual a angulação coronal dos túneis femoral e tibial que proporciona o melhor resultado no pós-operatório de cirurgia de reconstrução do LCA. As variáveis avaliadas foram os questionários IKDC e Lysholm-Tegner e o Hop-Test. MÉTODOS: Foram analisados 16 pacientes com pós-operatório entre 24 e 36 meses, com lesão isolada unilateral do LCA. Foram divididos em quatro grupos, nos quais os ângulos dos túneis tibial e femoral foram menores ou maiores do que 65° no plano coronal. RESULTADOS: A angulação do túnel tibial mais verticalizada (72°) e do túnel femoral mais horizontalizada (60°) com o alinhamento em valgo de 12° relacionou-se com os melhores valores para as variáveis estudadas, o que pode indicar um resultado ótimo para a cirurgia em longo prazo. CONCLUSÃO: A angulação femoral mais horizontalizada e a angulação tibial mais verticalizada têm melhores avaliações nos testes aplicados e nos resultados funcionais avaliados...

Key points summarization of 《Guidelines for the diagnosis and management of aplastic anemia (2009)》 / 中华实用儿科临床杂志

Aplastic anemia (AA) is one of serious hematopoietic diseases,clinical diagnosis and treatment is difficult.The guidelines for the diagnosis and management of aplastic anemia recommended (Guideline) by British Society for Haematology Committee in 2009,is made up of many experts based on experiences,used the method of evidence-based medicine,and collected all the reports of diagnosis and treatment of AA published in recent years,after strict screening screening and sums up the writing complete guidance document represented the principle and clinical methodology of diagnosis and treatment of AA in the mainstream view of world.The Guideline is comprehensive,on the basis of fully,opinionated,detailed,clinical maneuverability is strong,has a very high refe-rence value.In this paper,that selected and summarized of the contents closely related to the clinical diagnosis and treatment of AA from the guideline,in order to provide reference well to the colleague.

Histological response study of chronic viral hepatitis C patients treated with interferon alone or combined with ribavirin

Chronic hepatitis C is often a progressive, fibrotic disease that can lead to cirrhosis and other complications. The recommended therapy is a combination of interferon and ribavirin. Besides its antiviral action, interferon is considered to have antifibrotic activity. We examined the outcome of hepatic fibrosis and inflammation in chronic hepatitis C patients who were non-responders to interferon. We made a case series, retrospective study, based on revision of medical records and reassessment of liver biopsies. For inclusion, patients should have been treated with interferon alone or combined with ribavirin, with no virological response (non responders and relapsers) and had a liver biopsy before and after treatment. Histological evaluation included: i-outcome of fibrosis and necroinflammation; ii-annual fibrosis progression rate evaluation, before and after treatment. Seventy-five patients were included. Fifty-seven patients (76 percent) did not show progression of fibrosis after treatment, compared to six (8 percent) before treatment (p < 0.001). The mean annual fibrosis progression rate was significantly reduced after treatment (p = 0.036). Inflammatory activity improved in 19 patients (25.3 percent). The results support the hypothesis of an antifibrotic effect of interferon-based therapy, in non-responder patients. There was evidence of anti-inflammatory effects of treatment in some patients.

Etiology and Early Treatment Results of Acute Mesenteric Ischemia

PURPOSE: Acute abdominal pain can be the result of many different pathophysiological processes. Among the many possible causes, acute mesenteric ischemia is a life threatening condition if the diagnosis is delayed. Generally, the mortality rate for other disease has gradually decreased; however, the mortality rate for acute mesenteric ischemia has not changed significantly and it continues to be 75% to 80% for acute mesenteric arterial embolism or thrombosis and 44% for acute mesenteric venous thrombosis. The aim of this study was to conduct an analysis of the clinical characteristics and mortality of the patients with acute mesenteric ischemia according to the etiology. METHOD: From 1989 to 2004, 43 patients were treated for acute mesenteric ischemia. Their mean age was 59 years, ranging from 24 to 81, and the male to female gender ratio was 24:19. We retrospectively analyzed their initial symptoms, the age and gender distribution, the treatment modalities and the mortality rates. RESULT: The causes of acute mesenteric ischemia were arterial embolism in 27 cases, arterial thrombosis including arterial dissection in 7 cases and venous thrombosis in 9 cases. Almost all of the patients complained of acute abdominal pain and abdominal tenderness. The overall mortality rate was 30.2% and the rates were 37.0% for mesenteric artery embolism, 42.9% for mesenteric artery thrombosis and 0% for mesenteric venous thrombosis. CONCLUSION: In this study, the causes of acute mesenteric ischemia were mesenteric artery embolism and thrombosis, including dissection and mesenteric venous thrombosis. The factors influencing the mortality were the cause of the acute mesenteric ischemia, the extent of involvement of the mesenteric vessels and the extent of bowel necrosis. Thus the most important things for the treatment of acute mesenteric ischemia are early diagnosis and proper treatment.

EVALUATION ON EFFECTS AND SAFETY OF LAPAROSCOPIC VERTICAL BANDING GASTROPLASTY IN MORBID OBESE SUBJECTS / 解放军医学杂志

To evaluate the effects and safety of laparoscopic vertical banding gastroplasty (LVBG) in morbid obese subjects. The clinical data related to the metabolism of glucose, lipids and obesity in 26 obese Chinese patients with LVBG one year before and after the surgery were analyzed. The results showed that 1 year after LVBG, there was a reduction of 22.98?14.27kg in body weight, 9.31?5.13kg/m 2 in BMI, and a reduction of 47.19%?31.17% of body over-weight (EWL%) in these patients. BMI, waist, waist hip ratio, systolic blood pressure, fasting insulin, insulin resistance based on HOMA, triglyceride, cholesterol/HDL, ALT and blood creatine were decreased with reduction of body weight and BMI after LVBG. Changes in BMI and EWL% were significantly correlated with those of fasting insulin and insulin resistance. It is suggested that LVBG is effective and safe for reducing body weight and improving metabolism in the markedly obese patients.

Preliminary Results of Postoperative Radiotherapy after Breast Conserving Surgery in Early Breast Cancer / 대한암학회지

PURPOSE: To evaluate treatment results of breast conserving surgery and radiation therapy including survival rates, patterns of failure, and complication and to analyze prognostic factors. MATERIALS AND METHODS: Retrospective analysis was carried out for 111 (112 cases) consecutive patients with breast cancer treated by radiation therapy after breast conserving surgery from October 1994 to April 1997. The median follow up was 45 months (range 10~66). AJCC staging was as follows: 16 cases (14%) for ductal carcinoma in situ, 46 cases (41%) for stage I, 33 cases (30%) for stage IIa, and 17 cases (15%) for stage IIb. Radiation therapy after breast conserving surgery was delivered to whole breast with 50.4 Gy and additional 10 Gy electron beam boost to tumor bed. Adjuvant CMF or CAF chemotherapy was performed in 61 patients. RESULTS: Overall three- and five-year survivals were 99% and 95%, and progression-free survival were 93%, 87%, respectively. Treatment failure occurred in 11 cases (10%); loco-regional recur rence in six; distant metastasis in five. Univariate analysis showed prognostic factor affecting survival was only T-stage. Acute radiation dermatitis were found in five cases (4%), and chronic complications were found in five (4%); one case with amputation of nipple, two cases with lymphedema requiring rehabilitation therapy and two cases with symptomatic radiation pneu monitis requiring steroid therapy. CONCLUSION: Breast conserving therapy of early breast cancer including ductal carcinoma in situ showed high survival rates and low complications, and T stage was prognostic factor for survival. But further follow-up should be needed.

A Clinical Study of Malignant Tumors of the Maxilla

Malignant tumors of the maxilla represent about 3-4% of head and neck malignant neoplasm and the origins are maxillary gingiva, hard palate and maxillary sinus. We are to investigate clinical features and results according to various treatment modalities of maxillary malignant tumor to get information for better treatment results. Sixty patients with malignant maxillary tumors treated at Yonsei medical center from 1992 to 1997 were studied retrospectively. They are evaluated according to clinical signs & symptoms, stages at first diagnosis, primary site, histopathologic features, treatment method, recurrence and survival rate with clinical records, biopsy results and CT radiograph. The most common primary site was maxillary sinus and most common histopathology was squamous cell carcinoma. The local recurrence rate was 18% at 5 years, neck failure was 3% and distant metastasis was 18%. Overall survival rate was 78% at 2 years and 69% at 5 years. Failure at primary site is the main problem in the curative treatment. So, to improve survival in these patients efforts should be directed toward improvement of local control.