Prevention and treatment of high-risk human papilloma virus infection from the perspective of "prevention treatment of disease" based on the theory of "circular flow of Qi" / 国际中医中药杂志

The occurrence of cervical cancer in women is closely related to high-risk HPV infection, and timely and effective interruption of high-risk HPV infection is of great significance to prevent the occurrence of cervical cancer. Huang Yuanyou's theory of "circular flow of Qi" emphasizes on the harmonization of the overall Qi flow, which can explain the physiopathology of women. The occurrence of high-risk HPV infection is related to the loss of spleen and earth transportation in the middle Jiao, poor circulation of Qi, and the low resistance of the body to evil, resulting in the malfunctioning of clear and turbid. Based on the theory of "circular flow of Qi" combined with the idea of "prevention treatment of disease", the author proposes to "prevent the disease before it occurs, regulate the middle earth to preserve the correct Qi" and "prevent the disease before it occurs". The principles of prevention and treatment of high-risk HPV infection are "prevent before the disease, regulate the middle earth to preserve the righteousness", "promote and descend to dispel the poisonous evil", and "prevent recurrence after the disease, balance yin and yang and harmonize Qi and blood", in order to provide reference for clinical treatment.

Item Screening of the Clinical Aided Decision Scheme for Stroke Simultaneous Treatment of Disease,Pulse and Syndrome Based on Delphi Method / 中国中医药信息杂志

Objective To screen items of the Clinical Aided Decision Scheme for Stroke Simultaneous Treatment of Disease,Pulse and Syndrome;To provide reference for the formulation and improvement of the scheme.Methods The Delphi method was used to distribute two rounds of questionnaires to 60 experts in cerebropathy or neurology across the country.Statistical analysis was performed on the questionnaire results of the scheme's items,including the disease names,etiology and pathogenesis,syndrome characteristics,rules and regulations,representative prescriptions,acupuncture and other therapies,and preventive care.Results Totally 42 and 50 valid questionnaires were collected.The experts reached the consensus for the importance of etiology and pathogenesis,rules and regulations,acupuncture and other therapies,and preventive care.In the section on syndrome characteristics,items with low relevance or causing ambiguity were removed.Items that were no longer used in modern times and different prescriptions with the same name were removed from the representative prescriptions.The names of syndromes,rules and regulations were unified.Conclusion The experts generally reached the consensus for the importance of the Clinical Aided Decision Scheme for Stroke Simultaneous Treatment of Disease,Pulse and Syndrome.However,there are still some limitations that require further study and discussion.

Whole Course Management and Therapeutic Strategy of Traditional Chinese Medicine for Thrombocytopenia Induced by Tumor Treatment / 中医杂志

Based on the traditional Chinese medicine （TCM） theories of holism， syndrome differentiation and treatment， and preventive treatment of disease， the concept of whole course management of tumors throughout the treatment process is advocated. The strategy includes preventive treatment before tumor therapy， focusing on protecting the body's vital qi and strengthening the spleen and Qi. TCM formulas such as Sijunzi Decoction （四君子汤）， Shenling Baizhu San （参苓白术散） and Xiangsha Liujunzi Decoction（香砂六君子汤） are used to enhance platelet reserves. The main therapeutic methods during tumor conventional therapy include preventing disease transformation and strengthening vital qi to eliminate pathogenic factor， by invigorating spleen and soothing liver， nourishing liver and kidney， purging fire for removing toxin， and removing blood stasis for promoting tissue regeneration. TCM formulas such as Xiangsha Liujunzi Decoction （香砂六君子汤）， Shenling Baizhu Powder （参苓白术散）， Fuzi Lizhong Decoction （附子理中汤）， Zhibai Dihuang Decoction （知柏地黄汤）， and Qiangen Powder （茜根散）are used to reduce platelet destruction and depletion during tumor therapy and reverse the worsening trend. After tumor conventional therapy， the focus is on preventing relapse， adjusting the balance of Yin and Yang， by nourishing the kidneys， spleen， and lungs. TCM formulas such as Dingkun Pill （定坤丹）and Zuogui Pill （左归丸） are used with modifications to prevent thrombocytopenia. The staged prevention and treatment of tumor treatment-induced thrombocytopenia using TCM can maximize the benefits for patients.

A Nomogram model for the early warning of essential hypertension risks based on the principles of traditional Chinese medicine syndrome elements / 数字中医药（英文）

@#[Objective] To construct a Nomogram model for the prediction of essential hypertension (EH) risks with the use of traditional Chinese medicine (TCM) syndrome elements principles in conjunction with cutting-edge biochemical detection technologies. [Methods] A case-control study was conducted, involving 301 patients with essential hypertension in the hypertensive group and 314 without in the control group. Comprehensive data, including the information on the four TCM diagnoses, general data, and blood biochemical indicators of participants in both groups, were collected separately for analysis. The differentiation principles of syndrome elements were used to discern the location and nature of hypertension. One-way analysis was carried out to screen for potential risk factors of the disease. Least absolute shrinkage and selection operator (LASSO) regression was used to identify factors that contribute significantly to the model, and eliminate possible collinearity problems. At last, multivariate logistic regression analysis was used to both screen and quantify independent risk factors essential for the prediction model. The “rms” package in the R Studio was used to construct the Nomogram model, creating line segments of varying lengths based on the contribution of each risk factor to aid in the prediction of risks of hypertension. For internal model validation, the Bootstrap program package was utilized to perform 1000 repetitions of sampling and generate calibration curves. [Results] The results of the multivariate logistic regression analysis revealed that the risk factors of EH included age, heart rate (HR), waist-to-hip ratio (WHR), uric acid (UA) levels, family medical history, sleep patterns (early awakening and light sleep), water intake, and psychological traits (depression and anger). Additionally, TCM syndrome elements such as phlegm, Yin deficiency, and Yang hyperactivity contributed to the risk of EH onset as well. TCM syndrome elements liver, spleen, and kidney were also considered the risk factors of EH. Next, the Nomogram model was constructed using the aforementioned 14 risk predictors, with an area under the curve (AUC) of 0.868 and a 95% confidence interval (CI) ranging from 0.840 to 0.895. The diagnostic sensitivity and specificity were found to be 80.7% and 85.0%, respectively. Internal validation confirmed the model’s robust predictive performance, with aconsistency index (C-index) of 0.879, underscoring the model’s strong predictive ability. [Conclusion] By integrating TCM syndrome elements, the Nomogram model has realized the objective, qualitative, and quantitative selection of early warning factors for developing EH, resulting in the creation of a more comprehensive and precise prediction model for EH risks.

Characteristics of Traditional Chinese Medicine Syndromes and Treatments of COVID-19 Patients from Two Hospitals Based on “Treatment of Disease in Accordance with Three Conditions” / 中国实验方剂学杂志

ObjectiveTo explore the guidance value of “treatment of disease in accordance with three conditions” theory in the prevention and treatment of corona virus disease 2019（COVID-19） based on the differences of syndromes and traditional Chinese medicine（TCM） treatments in COVID-19 patients from Xingtai Hospital of Chinese Medicine of Hebei province and Ruili Hospital of Chinese Medicine and Dai Medicine of Yunnan province and discuss its significance in the prevention and treatment of the unexpected acute infectious diseases. MethodDemographics data and clinical characteristics of COVID-19 patients from the two hospitals were collected retrospectively and analyzed by SPSS 18.0. The information on formulas was obtained from the hospital information system （HIS） of the two hospitals and analyzed by the big data intelligent processing and knowledge service system of Guangdong Hospital of Chinese Medicine for frequency statistics and association rules analysis. Heat map-hierarchical clustering analysis was used to explore the correlation between clinical characteristics and formulas. ResultA total of 175 patients with COVID-19 were included in this study. The 70 patients in Xingtai，dominated by young and middle-aged males，had clinical symptoms of fever， abnormal sweating，and fatigue. The main pathogenesis is stagnant cold-dampness in the exterior and impaired yin by depressed heat， with manifest cold， dampness， and deficiency syndromes. The therapeutic methods highlight relieving exterior syndrome and resolving dampness， accompanied by draining depressed heat. The core Chinese medicines used are Poria，Armeniacae Semen Amarum，Gypsum Fibrosum，Citri Reticulatae Pericarpium，and Pogostemonis Herba. By contrast，the 105 patients in Ruili， dominated by young females， had atypical clinical symptoms， and most of them were asymptomatic patients or mild cases. The main pathogenesis is dampness obstructing the lung and the stomach， with obvious dampness and heat syndromes. The therapeutic methods are mainly invigorating the spleen， resolving dampness， and dispersing Qi with light drugs. The core Chinese medicines used are Poria，Atractylodis Macrocephalae Rhizoma，Glycyrrhizae Radix et Rhizoma，Coicis Semen，Platycodonis Radix，Lonicerae Japonicae Flos， and Pogostemonis Herba. ConclusionThe differences in clinical characteristics， TCM syndromes， and medication of COVID-19 patients from the two places may result from different regions，population characteristics， and the time point of the COVID-19 outbreak. The “treatment of disease in accordance with three conditions” theory can help to understand the internal correlation and guide the treatments.

Progress in the research of application of hot springs in health care and adjuvant treatment of diseases / 上海预防医学

Hot spring is a kind of precious natural water resource formed under specific geological conditions and obtained by natural gushing or artificial drilling, and is rich in minerals and trace elements peculiar to deep strata. Hot spring bathing is a physical therapy with a long history. An increasing number of studies have shown the positive effects of hot spring bathing in maintaining health and the auxiliary treatment and rehabilitation of chronic diseases. This paper reviews the distribution, classification and application history of hot springs, and further explores the research on the effect of hot springs on the improvement of sub-health status and the adjuvant treatment of chronic diseases such as skin diseases, cardiovascular diseases and joint diseases, so as to provide reference for further understanding of the physiotherapy value of hot spring bathing and boost its role in the development of big health industries.

A Summary of Health Preserving Thoughts of Confucianism，Buddhism，Taoism and Medicine (Ⅱ) / 中国实验方剂学杂志

Health-preservation thoughts of the four major schools (Confucianism, Buddhism, Taoism and Medicine) have important reference values for the health preservation and health care industry. The core of health-preservation thought of the Taoism is taking mind training as the focus and physical exercise as the supplementary means, Taoism is nature-admiring, emphasizes the idea of natural laws and inaction and humanity follows natural laws, as well as advocates following nature's courses, realizing the passive inaction, and keeping calmness, also, it advocates the way of keeping good health through preserving vital essence, energy and mentality, in order to achieve the purpose of training vital essence into energy, training energy into mentality and maintaining complete vital essence, energy and vitality. Through long-term development, Medicine has formed a relatively complete set of theoretical and systematic health-preservation methods. The holistic concept of Medicine emphasizes the uniformity among human, nature and society, considers human body as an organic whole, and advocates the health-preservation thoughts of living in harmony with nature, accommodating the four seasons, keeping good circulation of energy and blood, dredging collaterals, nourishing essence and replenishing energy, accumulating healthy energy and repelling pathogenic factors, maintaining the inseparability of the body and spirits, as well as taking proper exercises and keeping mental calmness. Based on the health-preservation thoughts of the four major schools, this paper summarizes the modern health-preservation guiding thoughts of dredging collaterals, nourishing essence, taking exercises and keeping mental calmness, in order to provide the theoretical guidance for traditional Chinese medicine health-preservation services.

Application of the thought of preventive treatment of disease by professor Cai Wanru in the treatment of stable chronic obstructive pulmonary disease / 中国现代医生

Professor Cai Wanru believes that in the stable phase of chronic obstructive pulmonary disease, "phlegm" and "stasis" are intertwined, with "phlegm" as the main component. Disease is manifested mostly in the lungs, spleen and kidney, and along with the duration of the disease, the patients are prone to "sputum", "stasis" and other pathological products, so that acute aggravating symptoms are often induced due to the transformation from "phlegm" to "stasis". The clinical manifestations are mainly the lack of righteousness, and various symptoms due to phlegm stagnation and blood stasis. Therefore, Professor Cai believes that the thought of "preventive treatment of disease" should be throughout the treatment of the disease. The thought is based on the principle of the relationships between the five internal organs. According to the characteristics of disease transmission, combined with the syndrome differentiation of physical constitution, the importance of strengthening the body resistance and nourishing the vigour was emphasized. In terms of the methods of treatment, methods such as nourishing the lungs and tonifying the spleen, warming the kidney and tonifying qi are often applied, so the prescription is flexible and the compatibility is rigorous. In terms of the control of symptoms and prevention of acute exacerbations, it has a significant effect. Therefore, the thought of "preventive treatment of disease" proposed by Professor Cai Wanru has a practical value in the clinical treatment of chronic obstructive pulmonary disease, which is worthy of promotion.

Effects of Different TCM Exercises for Preventive Treatment of Diseases on Sleep Quality, Depression and Anxiety of College Students / 中国中医药信息杂志

Objective To observe the effects of different TCM exercises for preventive treatment of diseases on sleep quality and multidimensional mental health level of college students.Methods According to the willing of the research objects, 132 college students were divided into Yijinjing group, Baduanjin group, Wuqinxi group, Tai Chi group, and jogging group. They exercised 45 min each time, 5–6 times per week, received central guidance every two weeks, and exercise intensity was timely adjusted based on master of physical activity and reaction to the situation of college students, for 2 months. PSQI, BFS, SDS and SAS before and after intervention in each group were observed. Results After intervention, five kinds of exercises could improve sleep situation of college students, and had their own focus in sleep quality, falling-asleep time, sleep time, sleep efficiency, sleep disorders, sleep medication, daytime dysfunction. There was statistical significance in BFS activity score, thought score, anger score, excitation score, and depression score after intervention in Yijinjing group compared with before intervention (P<0.05); There was statistical significance in activity score, total joy score, calm total score after intervention in Wuqinxi group compared with before intervention (P<0.05). There was statistical significance in SAS total scores of college students in Yijinjing group, Baduanjin group, and jogging group after intervention compared with before intervention (P<0.05). There was statistical significance in SAS standard scores of college students in Yijinjing group, Baduanjin group, and jogging group after intervention compared with before intervention (P<0.05). There was no statistical difference in SDS scores in the five groups before and after intervention (P>0.05).Conclusion 5 kinds of exercises can improve the sleep quality from different aspects. Yijinjing group and Wuqinxi group can improve the mental health of college students, of which Yijinjing group can bi-directionally regulate the positive and negative psychological indicators of college students.

Study on Clinical Consistency Evaluation in TCM Practice Guidelines for Prevention and Treatment of Biqiu (Allergic Rhinitis) / 中国中医药信息杂志

Zhangjiagang Hospital of Traditional Chinese Medicine, as a collaborative unit of the project, participated in the clinical consistency evaluation in project of TCM Practice guidelines for Prevention and Treatment of Biqiu (allergic rhinitis) organized by the State Administration of Traditional Chinese Medicine. The evaluation results showed that the guideline met the clinical practice requirements. This article summarized the clinical evaluation experience from the three aspects: The diagnosis in TCM and Western medicine is clear and definite, but the English translation needs to be considered; The definition of remission phase of Biqiu (allergic rhinitis) is difficult, to interfere by identifying the constitution is innovative; The advantages of "preventive treatment of diseases" in TCM should be fully played in role, improving the satisfaction of patients.

Generalized science of Chinese material medica-from preventive treatment of disease to Chinese medicine health industry / 中国中药杂志

Based on the systematic summary of the results of the fourth general survey of traditional Chinese medicine resources, the cultivation of large varieties of Chinese material medica and the latest research on health industrial development, the novel concepts and scientific connotations of generalized science of Chinese material medica are put forward, and the basic ideas and methods of a new Chinese medicine academic system, the cultivation system of large varieties of Chinese medicinal materials and the application system of the large health industry are constructed. This kind of generalized science of Chinese material medica, rooted in the traditional Chinese culture and the theory of "preventive treatment of disease", can avoid the narrow prospect induced by the increasing specialization and refinement of knowledge of science of Chinese material medica. It will play an important role in the modernization, industrialization, internationalization of traditional Chinese medicine.

Effect of Heat-sensitive Point Moxibustion on High-normal Blood Pressure in Persons with Yin or Yang Deficiency / 上海针灸杂志

Objective To investigate the effect of heat-sensitive point moxibustion on high-normal blood pressure in persons with yin or yang deficiency.Methods Eighty-six persons with high-normal blood pressure were randomized to a treatment group (42 cases, 20 with yin deficiency and 22 with yang deficiency) and a control group (44 cases, 19 with yin deficiency and 25 with yang deficiency). The control group received health education and diet guidance and the treatment group, heat-sensitive point moxibustion in addition. Both groups were followed up twice a week with blood pressure measured. The clinical therapeutic effects, hypertension diagnosis rates and neutral constitution transformation percentages were compared between the two groups of persons with different constitutions after one month of treatment.Results The total efficacy rate was 90.0％ in persons with yin deficiency and 100％ in persons with yang deficiency of the treatment group and correspondingly 78.9％ and 92.0％ of the control group; there was a statistically significant difference between the two groups (P<0.05). Post-treatment hypertension diagnosis rate 15.0％ in persons with yin deficiency and 9.1％ in persons with yang deficiency of the treatment group and correspondingly 36.8％ and 16.0％ of the control group; there was a statistically significant difference between the two groups (P<0.05). Post-treatment neutral constitution transformation percentage was 23.3％ in persons with yin or yang deficiency of the treatment group and 13.6％ in those of the control group; there was a statistically significant difference between the two groups (P<0.05).Conclusions Heat-sensitive point moxibustion can reduce high-normal blood pressure and hypertension incidence and effectively rectify biased constitution in persons with yin or yang deficiency.

Probe into lacking of protection in traditional Chinese medicine psychology pathogenesis / 国际中医中药杂志

Lack of protection in education was one of possible reason contributed to the traditional Chinese medicine(TCM) psychology pathogenesis while the research conducted. This paper discusseds the following aspects: the concept, the causes, the impact and the types of protection. It also provided series thought on the development of TCM psychology pathogenesis, TCM psychology family treatment and family education of TCM psychology prevention.

Preliminary Exploration in Construction of Three-level Service System of TCM Prevention and Health Care in Nanning Area of Guangxi Province / 中国中医药信息杂志

This article analyzed the present situation of development of TCM prevention and health care services in Nanning area of Guangxi Province, put forward a new mode of constructing regional TCM Prevention and health care service system: strengthen, clear and standardization, expounded the key points of implementation of construction of three-level health service system of TCM prevention and health care in Nanning area, practical significance of the construction of regional medical prevention and health care service system, and the advantages of three-level health service system of TCM prevention and health care. Finally, it summarized the experience in preliminary construction of three-level health service system of TCM prevention and health care services in Nanning area.

Analysis of the awareness of preventive treatment of disease and influencing factors in community residents in Shanghai / 上海交通大学学报（医学版）

Objective · To understand the awareness of preventive treatment of disease in community residents, analyze the influencing factors, and explore ways to improve the awareness and service utilization. Methods · Community residents over 18 years of age who were from 26 community health service centers which were randomly selected in Shanghai were surveyed with a self-designed questionnaire. General descriptive analysis was used for basic information and chi-square test for influencing factors. OR values were calculated and Logistic regression analysis was performed. Results · The awareness rate in community residents was low (57.1%). They got to know the preventive treatment of disease mainly through radio or television (48.4%), newspapers or magazines (36.9%), community propaganda (35.5%), and so on. The influencing factors were age, occupation, education, income, and ways to get to know the preventive treatment of disease. In short, the awareness rate and cognitive level in vulnerable groups were lower. Conclusion · The effects of current propaganda of the preventive treatment of disease is limited. The propaganda should be more scientific and pertinent, so as to deepen the cognition of community residents and promote the service utilization.

Analysis of the awareness of preventive treatment of disease and influencing factors in community residents in Shanghai / 上海交通大学学报（医学版）

Objective · To understand the awareness of preventive treatment of disease in community residents, analyze the influencing factors, and explore ways to improve the awareness and service utilization. Methods · Community residents over 18 years of age who were from 26 community health service centers which were randomly selected in Shanghai were surveyed with a self-designed questionnaire. General descriptive analysis was used for basic information and chi-square test for influencing factors. OR values were calculated and Logistic regression analysis was performed. Results · The awareness rate in community residents was low (57.1%). They got to know the preventive treatment of disease mainly through radio or television (48.4%), newspapers or magazines (36.9%), community propaganda (35.5%), and so on. The influencing factors were age, occupation, education, income, and ways to get to know the preventive treatment of disease. In short, the awareness rate and cognitive level in vulnerable groups were lower. Conclusion · The effects of current propaganda of the preventive treatment of disease is limited. The propaganda should be more scientific and pertinent, so as to deepen the cognition of community residents and promote the service utilization.

Progress on Clinical Research of Traditional Chinese Medicine-guided Prehypertension Treatment / 世界科学技术-中医药现代化

Hypertension is a chronic medical condition which is characterized by persistent elevation of arterial blood pressure.Hypertension is the most recognized risk factor for cardiovascular diseases.It has become one of the most important medical conditions threatening the public health worldwide.To achieve early prevention and reduce the incidence of hypertension and other related cardiovascular diseases,prehypertension had been proposed in 2003 as an important component of first-line preventive strategies targeting cardiovascular diseases.Progress on the clinical significance and mechanism associated with prehypertension has been made since the notion was proposed.Results from in-depth mechanistic studies of prehypertension have shed new light on the early prevention and treatment of hypertension and hypertension-caused target organ damage.It is worth noting that the concept of "treat before the onset of the disease" stated in traditional Chinese medicine (TCM) has been applied to the clinical research of prehypertension with increasingly recognized results.The current review thus summarized recent progress on the clinical research of prehypertension and TCM-guided prevention and treatment of prehypertension.

Analysis of TCM“Preventive Treatment of Disease”Service Selection Factors of Changsha / 中国中医药信息杂志

Objective To understand the influence factors and ratio of TCM“preventive treatment of disease”service selection of elderly people in communities of Changsha city. Methods Stratified random sampling method was used. Elderly people in two communities in Changsha city participated in the survey and were invited to fill in the questionnaires. The questionnaire was divided into three parts: social demographic characteristics of community residents;self-acknowledgement of community residents’ health (self-rated health and health management);community residents’ attitudes towards “preventive treatment of disease” service. Results Totally 360 questionnaires were distributed. Except for unqualified questionnaires, a total of 320 questionnaires were returned, with effective rate of 88.8%. Selection ratio of“preventive treatment of disease” service of elderly people in community was 86.2%. Different educational levels, professions, insurances, family incomes, self-rated health and health management had statistical significance with elderly people's selection of“preventive treatment of disease”service (P<0.05). Health management, self-rated health and the family income were important factors influencing elderly people's selection of TCM “preventive treatment of disease” services. Conclusion The carrying out of “preventive treatment of disease” service in community requires improvement of community residents’ awareness of self health management, and cheap route among people.

Construction of“Platform for Regional Traditional Chinese Medicine Preventive Healthcare Service”under the Linkage between Medical Institutions and Social Healthcare Institutions ;in Changning District of Shanghai / 中国中医药信息杂志

As the first national“preventive treatment of disease”preventive healthcare service pilot, Changning District in Shanghai has carried out the construction of TCM preventive healthcare service platform under the guidance of district leaders from 2009. By introducing the construction process and implementation key points of the pilot linkage patten of medical institution and social healthcare institutions in Changning District, this article put forward the construction ideas of “Platform for Regional Traditional Chinese Medicine Preventive Healthcare Service”, and further proposed challenges and opportunities for deepening reforms.

Effect of the theory of "preventive treatment of disease" in the treatment of chronic hepatitis B / 中国现代医生

Objective To verify the clinical efficacy of traditional chinese theory of "preventive treatment of disease"combined with Lamivudine in the treatment of chronic hepatitis B. Methods A total of 512 patients with chronic hep-atitis B were randomly divided into two groups, with 256 cases in each group. The control group received oral Lamivu-dine administration. The traditional chinese theory of "preventive treatment of disease" combined with Lamivudine were applied in the observation group. The course of treatment was 24 months. Values of ALT, negative rate of HBeAg, neg-ative rate of HBV-DNA were observed in different group and different stages. Results The results of observation group in values of ALT, negative rate of HBeAg, negative rate of HBV-DNA were superior to those of the control group (P<0.05). Conclusion Application of traditional chinese theory of"preventive treatment of disease"combined with Lamivu-dine can improve values of ALT, negative rate of HBeAg, negative rate of HBV-DNA, and also improve the clinical ef-ficacy in the treatment of chronic hepatitis B.