Clinical research of luterinizi releasing hormone anogist with zhibaidihuang pill treatment for girls idiopathic true precocious puberty / 中国基层医药

Objective To study the curative effect of luterinizi releasing hormone anogist(LRH-A) with Zhibaidihuang pill treatment for girls idiopathic true precocious puberty(ICPP).Methods 29 girls with ICPP,the breast in 3rd period were selected.9 of them were treated with LRH-A,12 of them were treated with LRH-A and Zhibaidihuang pill,8 of them as comparison group were no-treated.The growth speed,secondary sexual characteristics,bone age,LHRH inspire experiment,ultrasonic measurement of uterus volume and ovarian follicle size and forecast target of height were separately tested before and after treatment.Results Two groups after 4 period of treatment were compared:one group after only treated with LRH-A,the average growth speed was lower;The predict final target of height was not obviously increased;The secondary sexual characteristic reduced;The blood lever of E2,FSH and LH differ decreased;The bone age had no change.The other group after bio-treated with LRH-A and Zhibaidihuang pill,the average growth speed was slow down(P

A Case of True Precocious Puberty Complicating Congenital Adrenal Hyperplasia

Congenital adrenal hyperplasia(CAH) is a recognized cause of precocious pseudopuberty. Some children with CAH also develop true precocious puberty with early maturation of the hypothalamic-pituitary-gonadal axis. We review a case of CAH who eventually developed central precocious puberty nine months after initial treatment with corticosteroid. A 3-year-old boy visited complaining of rapid growth, a large penis and frequent penile erections. This patient was diagnosed with CAH with elevated 17-OH progesterone and cortical hypertrophy of adrenal gland on CT scan. His gonadotropin levels were within the normal prepubertal range. Even on treatment with corticosteroid he grew rapidly and had testicular enlargement, pubic hair development and rapid bone maturation. At second admission, his gonadotropin levels were elevated both basally and in response to LHRH stimulation, suggesting that the CAH led to early activation of pubertal gonadotropin secretion(true precocious puberty). He was treated with monthly depot injections of a LHRH analog in addition to the hydrocortisone. His second sexual characteristics regressed gradually and rate of linear growth and bone maturation decreased.

A Case of True Precocious Puberty Associated with Pituitary Microadenoma Treated with LHRH Agonist / 대한내분비학회지

Recently Brain CT and MRI have greatly contributed to the discovery of intracranial tumors including cysts which cause precocious puberty. Among many precocious pubetry patients that had previously been diagnosed as idopathic, a number of cases turn out the true precocious puberty caused by intracranial lesion.Authors experienced a case of true precocious puberty in a seven year old female whose vaginal bleeding appeared at age of five and she also had breast enlargement on admission. Pituitary microadenoma was found on her brain MRI and the microadenoma turned to be nonfunctional on hormonal tests.Following three does of decapety1-CR(LHRH Agonist), the vaginal bleeding was ceased and the deceleration of breast enlargement was noted. Her growth velocity was also affected but the further observation for final height would be warranted.