RESUMO
Background & objectives: There is a paucity of data regarding immunogenicity of recently introduced measles–rubella (MR) vaccine in Indian children, in which the first dose is administered below one year of age. This study was undertaken to assess the immunogenicity against rubella and measles 4-6 wk after one and two doses of MR vaccine administered under India’s Universal Immunization Programme (UIP). Methods: In this longitudinal study, 100 consecutive healthy infants (9-12 months) of either gender attending the immunization clinic of a tertiary care government hospital affiliated to a medical college of Delhi for the first dose of routine MR vaccination were enrolled. MR vaccine (0.5 ml, subcutaneous) was administered to the enrolled participants (1st dose at 9-12 months and 2nd dose at 15-24 months). On each follow up (4-6 wk post-vaccination), 2 ml of venous blood sample was collected to estimate the antibody titres against measles and rubella using quantitative ELISA kits. Seroprotection (>10 IU/ml for measles and >10 WHO U/ml for rubella) and antibody titres were evaluated after each dose. Results: The seroprotection rate against rubella was 97.5 and 100 per cent and against measles was 88.7 per cent and 100 per cent 4-6 wk after the first and second doses, respectively. The mean (standard deviation) titres against rubella and measles increased significantly (P<0.001) after the second dose in comparison to the levels after the first dose by about 100 per cent and 20 per cent, respectively. Interpretation & conclusions: MR vaccine administered below one year of age under the UIP resulted in seroprotection against rubella and measles in a large majority of children. Furthermore, its second dose resulted in seroprotection of all children. The current MR vaccination strategy of two doses, out of which the first is to be given to infants below one year of age, appears robust and justifiable among Indian children.
RESUMO
Background: India accounts for the highest number of under-five deaths in the world. Estimates claim that 89 lakh children in India receive fewer vaccines or no vaccine at all. One out of every three children in India does not receive all vaccines under the universal immunization programme. 5% children in urban and 8% children in rural areas remain unimmunized. According to NFHS-4 data complete vaccination coverage in India stands at 62%. The objectives of this study were to evaluate complete vaccination coverage, dropout rate and identify factors for failure of vaccination coverage in Doda district of Jammu and Kashmir, state of India.Methods: A cross-sectional quantitative study was conducted to evaluate the complete vaccination coverage by using an interview schedule devised as per WHO-UNICEF coverage cluster survey reference manual and National Immunization Schedule. A pre-determined sample size according to the WHO-UNICEF coverage cluster survey reference manual was adopted for the purpose of the study.Results: Of the total 207 children included in the study 66.2% (n=137) were fully immunized. 19.8% of the children had dropped out and did not receive the recommended dose of pentavalent vaccine. Among the reasons for low complete vaccination coverage, lack of awareness, mother too busy and vaccinator being absent were identified as the major reasons.Conclusions: Complete vaccination coverage has shown an increase with an increase in the coverage of the individual vaccines. But the coverage is still low and more efforts are needed to further improve the vaccination coverage.
RESUMO
Background: Immunization is an important cost effective tool for preventing the morbidities and mortalities caused by vaccine preventable diseases. The objectives of this study were to assess the universal immunization programme coverage of children of 12–23 months of age in Kozhikode district and to study the factors associated with immunization coverage.Methods: A cross sectional study was conducted in 30 randomly selected electoral wards of Kozhikode district which were selected using multi stage cluster sampling technique during April 2013 to May 2014.Results: 469 children were studied from 30 clusters. 75.5% was fully immunized while 1.5% was unimmunized. Dropout rate for DPT 3 to Measles was the highest accounting to 20.2%. Most common reason for failure of immunization among unimmunized was that the parents didn’t feel the need (57.1%) and for partially immunized was the illness of the child (27.8%) followed by lack of awareness of the time of immunization (22.2%). Religion, early age of the mother at marriage and first delivery and high birth order were significantly associated with a higher proportion of partially immunized while higher education of the parents (>12th standard), health worker’s home visit in the first year of the child and presence of immunization card were significantly associated with a high full immunization coverage (p<0.05).Conclusions: Immunization coverage of 75.5% is far behind the target to be achieved. 1.5% of the children didn’t get any of the vaccinations. It is very important to increases the coverage to prevent the re-emergence of vaccine preventable diseases.
RESUMO
Background: Immunization remains an important public health intervention. On one side morbidity and mortality caused by vaccine-preventable diseases are still high in developing countries, on the other side immunization coverage is still low. Present study aims to assess immunization status of under-five children in relation to various demographic variables of their mothers.Methods: A total of 530 mothers with children under 5 years attending OPD, immunization clinic or admitted in paediatric ward were included in the study. Maternal demographic variables like age, religion, education, socio economic status, residence, parity and occupation were compared with immunization status of their children.Results: Most of mothers were housewives (73.77%), primary educated (33.58%), belonged to Hindu religion (47.54%), were of 21-30 years age group (52.64%), residing in urban areas (62.07%) and belonged to middle socio economic status (45.84%). Out of total 530 children 161 (30.37%) were completely immunized as compared to 21.32% who were unimmunized. Boys were marginally more unimmunized (37.32%) than girls (23.04%). Mothers' education, occupation, parity, religion, residence and socio-economic status significantly influenced immunization status of their children (p<0.05).Conclusions: Therefore, it is recommended that any strategy formulated to improve vaccination coverage in children of our country should focus to strengthen above mentioned weak links.