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Objective:To compare the serum uric acid levels among employees with different psychological states.Methods:From January 2019 to August 2021, 200 in-service employees of various enterprises and public institutions receiving health screening in PLA General Hospital were selected as the participants for this study. Based on the scores of psychological stress, anxiety, and depression scale, each of the three psychological states was divided into four groups from mild to severe. The baseline data, serum uric acid level, creatinine level, and urea nitrogen level of participants were studied to explore the relationship between different psychological states and changes serum uric acid level.Results:According to the degree of psychological stress, anxiety, and depression, serum uric acid levels were 198.52±30.24 μmol/L, 256.52±10.33 μmol/L, 354.20±15.54 μmol/L, and 399.20±20.20 μmol/L ( F value 694.662, P<0.001), respectively. There was statistical difference in serum uric acid level of employees with different psychological statuses; with the aggravation of psychological status, the serum uric acid level showed a trend of gradually increasing from low to high. There was a positive correlation between the scores of different psychological states and uric acid level ( r=0.885, 0.780, 0.794, P<0.05), and no correlation between uric acid level and creatinine and urea nitrogen levels ( r=1.869, 3.887, 5.798, P>0.05). Conclusions:The serum uric acid level of employees varied with different types of psychological states. The greater the psychological stress is,the more serious the degree of depression and anxiety and the higher the serum uric acid level would be. The increase in uric acid level has no relationship with creatinine and urea nitrogen level.
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Background: Present evidence shows that increased uric acid level is a negative prognostic factor in patients with moderate to severe heart failure. A study has highlighted a correlation between serum uric acid levels and Killip class in patients of acute myocardial infarction (AMI). Aim of this study the relationship between serum uric acid level and Killip classification in patients with AMI.Methods: Sixty patients with AMI were studied prospectively in Department of Medicine/ Department of Cardiology, JA Group of Hospitals between 2016-2018. Patients were grouped based on the Killip class. Age, sex, history of smoking, alcohol consumption, hypertension and diabetes were recorded. Serum uric acid level were measured on Day 1, 3 and 5, which was compared with Killip class.Results: Majority of the patients were males (65%) and had age between (28.3%) 51-60 years. No significant association was obtained between any risk factors of AMI and Killip’s class (p>0.05). Serum uric acid levels were significantly higher in Killip grade III (7.80±3.57) as compared to Killip’s grade II (6.64±2.88) and I (6.30±2.33) (p=0.014). Majority of the patients with Killip’s grades I and II, had uric acid level ≤7.0 mg/dl (n=18 and n=9 respectively) (p=0.040). Serum uric acid was equally distributed among different types of killip’s grades between patients who expired and survived. (p>0.05).Conclusions: Serum uric acid levels has been found to be well correlated with Killip classification in patients with AMI. Combination of Killip class and serum uric acid level after AMI is a good predictor of mortality after AMI.
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Importance: The increasing prevalence of dementia worldwide has reduced the quality of life in geriatric patients, therebyincreasing the burden on the caregivers. As dementia evolves gradually, diagnosis of the disease is often delayed. Thus, theneed for a sensitive biomarker for early diagnosis is instrumental.Objective: The objective of the study was to study the association between serum uric acid levels and dementia in geriatric patients.Design: This is a case–control study comparing the age-matched geriatric patients with and without dementia (cases – 50and controls – 50).Setting and Participants: A total of 100 geriatric patients from Government Villupuram Medical College and Hospital wereincluded in this study for a study period of 4 months. Out of this, 50 were cases (with dementia) and 50 were controls (withoutdementia). Mini-mental state examination test was done to categorize the cases into mild, moderate, and severe subgroups(24–30 out of 30 as normal; 20–23 out of 30 as mild; 10–19 out of 30 as moderate; and score lesser than 10 out of 30 as severe).Serum uric acid levels were measured in the study population and compared between the cases and controls.Results: The correlation of serum uric acid levels with cases and controls revealed 16% of the cases had hypouricemia,whereas none in the control group had hypouricemia. When serum uric acid levels were compared, it was found that 44% ofthe control group had normal serum uric acid levels and 82% of the cases had normal serum uric acid levels. Based on minimental state examination score, 10% of mild group and 21% of moderate group had hypouricemia and 4% of moderate grouphad hyperuricemia while the others had normal serum uric acid levels. All the data were statistically significant with “P” < 0.001.Conclusion: The study identified the prevalence of hypouricemia in the study population. This study can pave the path forfurther multicentric research to delineate the role of uric acid level as potential biomarker for dementia.Relevance: The information gained from this study will enable us to diagnose dementia in the early stages and improve thequality of life of the patients.
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Objective To investigate the effect of preoperative serum uric acid level on the incidence of acute kidney in-jury after off-pump coronary artery bypass grafting and to discuss whether serum uric acid level is an independent predictor of postoperative acute kidney injury.Methods A total of 631 patients undergoing off-pump coronary artery bypass grafting in Anzhen Hospital from January 2018 to June 2018 were reviewed.Patients were divided into high uric acid group(higher-than-median)and low uric acid group(lower-than-median) , based on the preoperative serum uric acid level of the patients.The de-mographic variables, comorbidities, the chelsea comorbidity index, preoperative medication, serum creatinine level and glo-merular filtration rate were compared between the two groups.Meanwhile, intraoperative operative time, infusion volume, post-operative acute kidney injury staging and the rate of frozen plasma usage , continuous renal replacement therapy and reoperation rate were observed.Results Among the 631 patients, 83(13.2％, 83/631)cases developed postoperative acute kidney inju-ry, 65(78.3％, 65/83) cases had a higher level of preoperative serum uric acid above the median(OR =3.143, 95％CI:1.850-8.798, P=0.001).After adjustment, multivariate analysis showed that elevated level of serum uric acid and BMI >30 kg/m2, the increase of preoperative serum creatinine level, the decrease of glomerular filtration rate( <60 ml/min) and higher CCI score were associated with postoperative acute kidney injury independently .Intraoperative fluid volume , diabetes and preoperative diuretic administration did not relate to the incidence of acute kidney injury after cardiac surgery .Conclusion Elevated serum uric acid level can be a strong predictor for the incidence of acute kidney injury after off-pump coronary artery bypass grafting.
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Background: Obesity increases the risk for developing the cardiovascular disease because of the adverse effects caused by visceral fat accumulation than due to the accumulation of subcutaneous fat, which constitutes more than eighty-five percent of total body fat. Among Indians, CAD appears a decade earlier compared with the age than in developed countries. Aim of the study: To determine the association of Body mass index and waist circumference for the risk of developing coronary artery disease. Materials and methods: The current study was done at Government Mohan Kumaramangalam Medical College and Hospital, Salem at, Department of Medicine from our inpatient and outpatient departments from August 2017 to August 2018. Totally 100 patients were included in the study. The patient was considered to be obese if his or her body mass index calculated by Wt in kg / Ht in m2 was > 25 Kg /m2 . Abdominal circumference was measured at the level equidistant between the costal margin and iliac crest. ECG, Lipid profile was measured by standard measures. Results: The Mean Age in the study group was 51.28 with SD of 7.7 years and Mean age in the Control group was 53.3 with SD of 5.5 years. In our study Waist circumference and body mass index were measured and analysed for the risk of coronary artery disease. It showed that both BMI and Waist circumference correlates well with risk for developing coronary artery disease, and Waist circumference measurement was superior to BMI in assessing the risk of CAD. Thus our study A. Prabhu, Kumar R. Comparative study of waist circumference and body mass index in obese patients for the risk of developing coronary artery disease. IAIM, 2019; 6(8): 65-69. Page 66 highlights the importance of a simple measurement of waist circumference and BMI in day to-day clinical practice in detecting the patients with high cardiovascular risk. Conclusion: A BMI of ≥ 25 and waist circumference of > 90 cm in males and > 80 cm in females increases the sensitivity of detecting high risk for coronary artery disease. Waist circumference is more sensitive in predicting the risk than BMI chiefly because of its potential to measure central adiposity.
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Objective To explore thelevels of uric acid,blood pressure,serum lipid metabolic disorders and the distribution of obesity and metabolic syndrome (MS) among Uygur,Han and Kazak pre-diabetic groups in Xinjiang.Methods A cross-sectional study was conducted on 2053 Uygur residents,2219 Kazak residents and 2656 Han residents aged 30-80,all with prediabectic syndromes.The pre-dialectic patients were divided into three groups for analysis on metabolic features and inter-group comparisons.Results (1)In total,1934 pre-diabetic cases (28.3％) were diagnosed,with the highest prevalence (31.6％) seen in Uygurs and the lowest (25.5％) in Kazaks and medium (27.0％) in Hans.Data from the inter-group comparison showed statistically significant differences (P=0.00).(2) Prevalence of high LDL-C was 80.5％,with hyperuricemia as 30.3％ and MS as 58.3％,while the inter-group comparison did not show any statistically significant differences (P＞0.05).(3)Prevalence of pre-diabetic when combined with hypertension or earlier-stage hypertension,reached 88.0％,with the highest (96.8％) among Kazak group,85.1％ in Uygurs and 83.7％ in Han population.Data from the inter-group comparison showed statistically significant difference (x2 =59.959,P=0.00).(4)The overall prevalence of prediabectic,when combined with obesity was 35.4％,with 29.6％ in Han,36.8％ in Uygur and 41.0％ in Kazak groups.Data from the inter-group comparison showed statistically significant difference (x2=19.097,P=0.00).Conclusion According to results from this cross-sectional study regarding the metabolic features of Uygur,Kazak and Han prediabectic groups,differences were seen in the prevalence rates of pre-diabetic among Uygur,Kazak and Han ethnic groups,with the highest seen in Uygurs and the lowest in Kazaks.Hyperlipidemia,hypertension,hyperuricemia,MS and obesity were commonly seen in all the prediabectic groups,with the highest prevalence of hypertension seen in the Kazak group and the highest rate of obesity in Uygur group.
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The debate over the clinical meaning of plasma uric acid level is still a very hot issue. As the interest in health grows larger in the general public, the number of having a regular health check-up is increasing rapidly. Most of the health care centers routinely check the plasma uric acid level but it is not simple to interpret and explain the appropriate meaning of that. Over the past decade, there have been several studies on clinical implication of plasma uric acid level but the question still remains. However the clinical significance of the results might be different according to the severity of cardiovascular risk among subjects studied, and the findings for correlation with the established risks have enough proof to be applied to clinical practice. Additionally, the uric acid-lowering agents should not be used in general population even though it has reason to be prescribed in a specific high risk patient. Thus, this review seeks to be helpful in clinical practice by examining the preexisting related studies in a different perspective.
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Humanos , Atenção à Saúde , Hiperuricemia , Plasma , Ácido ÚricoRESUMO
Currently, uric acid disorders, especially including hyperuricosuria, are thought to be important in the formation Of idiopathic calcium urolithiasis. Herein, we estimated the serum concentration and urinary excretion of uric acid in I22 stone-formers, comparing to those in 56 controls. Also, various theories about the pathogenesis of uric acid disorder and stone formation were discussed. The results were as follows: 1. Serum uric acid levels of stone-formers were significantly higher than those of controls, in total and female, but, not in male. 2. Urinary uric acid levels of stone-formers were significantly higher than those of controls in total, male and female. 3. Hyperuricemia was significantly more frequent for stone-formers in total, male and female. 4. Hyperuricosuria was significantly more frequent for stone-formers in total, but, not significantly more frequent for stone-formers in male and female. 5. The incidence of stone-formers, in whom hyperuricemia and hyperuricosuria were not present at the sometime, was significantly less than that Of controls. These results suggest the possibility that uric acid disorder may play some roles in the genesis of urinary stone.