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Objective To investigate the significance of laparoscopic hysterectomy combined with MTX and mifepristone in the treatment of uterine scar pregnancy. Methods 86 patients with uterine scar pregnancy from July 2015 to May 2017 in our hospital were selected as the subjects, were randomly divided into control group and experimental group, each group of 43 cases. The control group was treated with MTX and mifepristone, intramuscular injection of 50 mg/m2 methotrexate, mifepristone orally, 3 times a day. The patients in the experimental group received laparoscopic monitoring, combined with MTX and mifepristone treatment. The hospitalization time, cure rate and vaginal bleeding time of the experimental group and the control group were compared and analyzed. Results The success rate of the experimental group was 100.00%, which was significantly higher than that of the control group (72.42%), and the difference was statistically significant (P<0.05). The vaginal bleeding time in the experimental group was (20.87±6.54) days, significantly shorter than the control group, and the number of days was (34.20±10.89) days, with statistical difference (P<0.05). In the experimental group, the time required for the decrease of beta -HCG to normal was (26.90±9.21), and the time required for the decrease of beta-HCG to normal in the control group was (45.66±10.29), with statistical difference (P<0.05). Conclusion Laparoscopic monitoring uterine aspiration combined with Methotrexate and mifepristone in the treatment of uterine scar pregnancy ideal clinical curative effect, can significantly improve patients' clinical symptoms, high success rate, and faster recovery, high safety.
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Objective To investigate the significance of laparoscopic hysterectomy combined with MTX and mifepristone in the treatment of uterine scar pregnancy. Methods 86 patients with uterine scar pregnancy from July 2015 to May 2017 in our hospital were selected as the subjects, were randomly divided into control group and experimental group, each group of 43 cases. The control group was treated with MTX and mifepristone, intramuscular injection of 50 mg/m2 methotrexate, mifepristone orally, 3 times a day. The patients in the experimental group received laparoscopic monitoring, combined with MTX and mifepristone treatment. The hospitalization time, cure rate and vaginal bleeding time of the experimental group and the control group were compared and analyzed. Results The success rate of the experimental group was 100.00%, which was significantly higher than that of the control group (72.42%), and the difference was statistically significant (P<0.05). The vaginal bleeding time in the experimental group was (20.87±6.54) days, significantly shorter than the control group, and the number of days was (34.20±10.89) days, with statistical difference (P<0.05). In the experimental group, the time required for the decrease of beta -HCG to normal was (26.90±9.21), and the time required for the decrease of beta-HCG to normal in the control group was (45.66±10.29), with statistical difference (P<0.05). Conclusion Laparoscopic monitoring uterine aspiration combined with Methotrexate and mifepristone in the treatment of uterine scar pregnancy ideal clinical curative effect, can significantly improve patients' clinical symptoms, high success rate, and faster recovery, high safety.
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OBJECTIVE:To investigate the efficacy and safety of methotrexate (MTX),Mifepristone combined with Huayu xiaozheng decoction in the treatment of uterine scar pregnancy. METHODS:86 patients with uterine scar pregnancy were randomly divided into control group(43 cases)and observation group(43 cases). Control group orally received 50 mg ultrasound-guided lo-cal injections of MTX,once a day+50 mg Mifepristone tablet,twice a day;observation group additionally received 100 ml Huayu xiaozheng decoction,twice a day with warm temperature. The treatment course for both groups was 15 d. Clinical efficacy,HCG levels,mass diameter before and after 7,14 and 28 d of treatment,and the incidence of adverse reactions in 2 groups were ob-served. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was sta-tistically significant(P0.05). CONCLUSIONS:Ultra-sound-guided local injections of MTX combined with Huayu xiaozheng decoction shows good efficacy and safety in the treatment of uterine scar pregnancy.
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Objective To compare effect of trichosanthin and methotrexate in the treatment of uterine scar pregnancy by a multi-center study. Methods 90 uterine scar pregnancy patients were selected from department of obstetrics and gynecology,in xinyang central hospital,the second affiliated hospital of zhengzhou university,zhumadian central hospital,using random number table divided into 2 groups.The control group of 45 cases were treated by methotrexate,gluteal muscle injection,50 mg one time,and took mifepristone 50 mg,two times a day,a week for a course of treatment;45 cases in the experimental group,were treated with trichosanthin,intramuscular injection of 1.2 mg/time,two times a day,and oral administration of bloven,0.6 g/d,a week for a course of treatment.The end of a course of treatment,2 groups of patients before and after treatment were compared of the serum progesterone level,β-HCG,side reactions after treatment.Results After treatment,progesterone levels were significantly reduced,and the experimental group levels were lower than the control group obviously,the difference has statistical significance(P<0.05).Serum -HCG level after the treatment significantly reduced,and the experimental group in serum -HCG levels were significantly lower,with statistical difference (P <0.05 ). Comparison of adverse reaction of the patients,the experimental group was obviously lower than control group,with statistically significant difference (P<0.05).Conclusion For the treatment of uterine scar pregnancy,trichosanthin and methotrexate have certain effect,but trichosanthin could lower serum progesterone,β-HCG levels more significantly than methotrexate,trichosanthin group side reaction rate is low.
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Objective To investigate the clinical value of uterine artery embolization on the treatment of cesarean scar pregnancy(CSP).Methods Clinical data of 112 cases of CSP patient underwent uterine artery embolization in Ningbo Women and Children's Hospital from January to December 2012 were enrolled for retrospectively analysis.Results All 112 patients underwent transvaginal ultrasound examination before admitted to hospital and among them 101 cases were diagnosed as CSP and 11 cases were suspected of CSP.Ninety-four cases were checked by magnetic resonance imaging (MRI) to measure the muscular thickness of uterine scar and the size of pregnant bursa.All patients received bilateral uterine artery embolization successfully,50-100 mg Methotrexat (MTX) were injected into uterine artery during this procedure.After uterine artery embolization,95 cases received curettage under ultrasound guidance,while 17 cases received curettage under hysteroscopy.All patients recovered as schedule.During the follow-up,no serious complication was found.Conclusion The use of uterine artery embolization in the treatment of CSP is safe and effective,and it can preserve patients' fertile ability.It is worthy recommended in the clinical application.