Válvula aórtica bivalva con cambios de degeneración mixoide asociados / Bivalve aortic valve with associated myxoid degeneration changes

Resumen:En la actualidad con el uso generalizado de los antibióticos, la fiebre reumática ha perdido el primer puesto como causa de afección de las válvulas del corazón, cediéndolo a otras patologías como el debilitamiento del tejido de la válvula ocasionado por la degeneración mixomatosa, el acumulación de calcio en las válvulas denomina degeneración cálcica, o el hecho mismo de nacer con una válvula de forma irregular como lo es válvula aortica bivalva. Precisamente, esto da pie a la presentación del caso de un joven masculino conocido sano de 16 años de edad el cual muere de forma súbita mientraspractica el ciclismo de forma recreativa.

Summary:Today with the widespread use of antibiotics, rheumatic fever has lost first place as a cause of disease of the heart valves, ceding it to other pathologies such as the weakening of the tissue of the valve caused by myxomatous degeneration, the accumulation of calcium valves called calcific degeneration, or being born with a valve same irregular shape as bicuspid aortic valve is. Precisely, this leads to the presentation of the case of a healthy young male known 16-year- old who suddenly dies while practicing cycling recreationally.

Familial mitral valve prolapse in a Maltese dog family / 동물의과학연구지

Mitral valvular prolapse (MVP) in dogs is characterized by myxomatous valvular degeneration, which is caused by abnormal valvular thickening and incomplete coaptation of the mitral valve leading to mitral regurgitation. Mitral regurgitation causes left atrial and left ventricular enlargement. Pathogenesis of the disease is unknown, although some studies have suggested the involvement of endothelin and systemic connective tissue diseases. Mitral valvular prolapse in dogs commonly occurs in aged small dog breeds, including Malteses and Shih Zhus. This case study investigated the clinical features of an affected Maltese family and performed pedigree analysis. To the best of the authors' knowledge, this is the first report of putative familial mitral valve prolapse and regurgitation in Maltese dogs. All family members in this study showed degenerative valvular changes and echocardiographic features of mitral valvular prolapse. Although disease progression differed, all dogs progressed to advanced heart failure stage within 2-3 years after diagnosis. Therefore, this is the first study to identify putative familial mitral valve prolapse in Maltese dogs. This finding suggests strong genetic etiology involved in the development of degenerative mitral valve disease in Maltese dogs. Furthermore, this finding could be a valuable resource for the identification of gene mutations in dogs with familial mitral valvular prolapse.