Specificity of white dermographism in atopic dermatitis and the relationship between its duration and clinical severity of atopic dermatitis / 中华皮肤科杂志

Objective@#To assess the specificity of white dermographism in atopic dermatitis (AD) , and to investigate the relationship between its duration and severity of AD.@*Methods@#From 1st to 30th March 2018, 78 patients with AD (AD group) , 100 patients with non-AD skin diseases (non-AD group) and 100 healthy controls without skin diseases (control group) were enrolled from Department of Dermatology, Wuhan No.1 Hospital. Dermographism test was conducted in each subject, and the subjects′ response and duration of white dermographism were observed. Meanwhile, the severity of skin lesions of the AD patients was evaluated. Statistical analysis was carried out by using Chi-square test, analysis of variance and linear correlation analysis.@*Results@#Of the 78 patients in the AD group, 67 (85.90%) were positive for white dermographism, and the positive rate of white dermographism was significantly higher in the AD group than in the non-AD group (18.00% [18/100], χ2 = 80.97, P<0.017) and control group (5.00% [5/100], χ2 = 119.05, P<0.017) . Additionally, the positive rate of white dermographism was significantly higher in the non-AD group than in the control group (χ2 = 8.30, P<0.017) . The average duration of white dermographism was 1.89 minutes in 30 patients with mild AD, 2.74 minutes in 25 patients with moderate AD, and 4.41 minutes in 12 patients with severe AD. There was a significant difference in the duration of white dermographism among the 3 AD subgroups (F = 64.588, P<0.05) . Moreover, the severity of AD was positively correlated with the duration of white dermographism (r = 0.977, P = 0.136) .@*Conclusion@#White dermographism is a specific clinical manifestation of AD, and its duration is positively correlated with the severity of AD.

Specificity of white dermographism in atopic dermatitis and the relationship between its duration and clinical severity of atopic dermatitis / 中华皮肤科杂志

Objective To assess the specificity of white dermographism in atopic dermatitis (AD), and to investigate the relationship between its duration and severity of AD. Methods From 1st to 30th March 2018, 78 patients with AD (AD group), 100 patients with non-AD skin diseases (non-AD group)and 100 healthy controls without skin diseases(control group)were enrolled from Department of Dermatology, Wuhan No.1 Hospital. Dermographism test was conducted in each subject, and the subjects' response and duration of white dermographism were observed. Meanwhile, the severity of skin lesions of the AD patients was evaluated. Statistical analysis was carried out by using Chi-square test, analysis of variance and linear correlation analysis. Results Of the 78 patients in the AD group, 67(85.90％)were positive for white dermographism, and the positive rate of white dermographism was significantly higher in the AD group than in the non-AD group(18.00％[18/100],χ2=80.97, P<0.017)and control group(5.00％[5/100],χ2=119.05, P<0.017). Additionally, the positive rate of white dermographism was significantly higher in the non-AD group than in the control group (χ2 = 8.30, P<0.017). The average duration of white dermographism was 1.89 minutes in 30 patients with mild AD, 2.74 minutes in 25 patients with moderate AD, and 4.41 minutes in 12 patients with severe AD. There was a significant difference in the duration of white dermographism among the 3 AD subgroups(F=64.588, P<0.05). Moreover, the severity of AD was positively correlated with the duration of white dermographism(r=0.977, P=0.136). Conclusion White dermographism is a specific clinical manifestation of AD, and its duration is positively correlated with the severity of AD.

Evaluation of Vascular Response using Impedance Plethysmography in Patients with Spinal Cord Injury

OBJECTIVE: To determine abnormal vascular response to cuff ischemia in patients with spinal cord injury (SCI). METHOD: Ankle blood pressure (ABP) and ankle-brachial index (ABI) in 20 SCI patients (14 men, 6 women, mean age 39.8 years) and control group (14 men, 6 women, mean age 40.2 years) were measured using impedance plethysmography at rest and after distal thigh cuff compression for 5 and 10 minutes. The patients were divided into tetraplegia (10), paraplegia (10), complete injury (8) and incomplete injury (12). RESULTS: There was no significant difference in ABP and ABI at rest and 5 minutes of ischemic compression between the patients and control groups. However, ABP and ABI decreased more at 10 minutes of ischemic compression in SCI compared to control groups (p<0.001). Changes of ABP and ABI between tetraplegia and paraplegia were not different. Complete injury of SCI decreased more than incomplete injury at 10 minutes of ischemia in the APB and ABI (p<0.001). CONCLUSION: Vascular control was significantly impaired in patients with spinal cord injury. Impedance plethysmography can be a useful and objective tool in evaluation of vascular response for the patients with spinal cord injury.

Time Responses to Nitric Oxide and Endothelin-1 in the Rabbit Basilar Artery with Vasospasm / 대한뇌혈관학회지

OBJECTIVES: This study aimed at clarifying the character of cerebral artery vasospasm on rabbit model by observing the vascular responses to nitric oxide and endothelin-1 treatment at different time points. MATERIALS AND METHODS: Twenty-eight rabbits undertook vertebrobasilar angiographies on the postoperative 2nd day and the 7th day after subarachnoid hemorrhage operation. The animals were divided into the vasospasm and the non-vasospasm group accroding to the result of vertebrobasilar angiographies. After sacrificing the animal, the vascular ring of harvested basilar artery was suspended in Krebs solution organ chamber for observation of isometric tension change in response to nitric oxide (NO) and endothelin-1 under high (95% O2 / 5% CO2) and low (95% N2 / 5% CO2) O2 tension. To investigate NO-dependent the vascular relaxation response, acetylcholine (10-7-3x10-4 M) was applied to basilar artery ring preconcentrated with histamine (10-6-10-5 M) in the organ chamber. The vascular contraction response was observed by applying endothelin-1 (10-11-3x10-8 M) into the organ chamber. RESULTS: The angiography showed vasospasm in seven of fifteen rabbits of the postoperative-2-day group (64.3+/-11.2%) and seven of fifteen rabbits of the postoperative-7-day (64.9+/-10.9%). On the postoperative-2-day, all the vascular response to NO and endothelin-1 under both high and low O2 tension was not significantly different between the vasospasm developed basilar artery and the vasospasm undeveloped one. On the postoperative-7-day, the vascular relaxation response to NO under high O2 tension was significantly different between the vasospasm developed basilar artery and the vasospasm undeveloped one (p=0.029). However, the vascular relaxation response to NO under low O2 tension was not significantly different. The vascular contraction response to endothelin-1 under high O2 tension was significantly different between the vasospasm developed basilar artery and the vasospasm undeveloped one (p=0.032). However, the vascular contraction response to endothelin-1 under low O2 tension was not significantly different. CONCLUSION: This experiment suggest that the vasospasm of the postoperative-2-day have different character from that of the postoperative-7-day in the rabbits. This suggestion may play some roles in the future study of the subarachnoid hemorrhage model. the study of the vasospasm mechanism of human, and developing antispasmodic drugs.

A study of the abnormal cutaneous vascular response in atopic dermatitis / 대한피부과학회지

The delayed blanch is one of the most discussed but undecided facets of atopic dermatitis as yet. At present, they favor the theory that delayed blanch is due to vasoconstriction, but it is not obvious whether this is due to "true" vasoconstriction or to the blood vessels being narrowed by the surrounding exudative edema, resulted from vasodilatation and increased capillary per meability. We compared cutaneous response of severe atopic dermatitis with that of age matched non-atopic individuals after intradermal injection of acetylcholine by means of naked eye and laser Doppler flowmeter examination, control group showed flare and wheals while at,opy group resulted in delayed blanch in addition to flare and whealing. The results of laser Doppler flowmeter examination revealed that, as compared to baseline, atopy group showed statistically significantly increase in spite of delayed blanch. We suggested that the delayed blanch may be not due ta va.soconstriction but due to the vasadilatation and aceumulation of edema fluid.