Experimental study on improvement of blood supply timeliness of rabbits with vertebral artery type of cervical spondylosis by massage / 中国骨伤

<p><b>OBJECTIVE</b>Establishing a rabbit model of vertebral artery type of cervical spondylosis(CSA) and to observe the characteristics of timeliness in improving the blood flow of vertebral artery by massage, and discusse the material basis of this timeliness based on NPY and ET-1.</p><p><b>METHODS</b>Fifty New Zealand healthy and white rabbits, 6-month-old, the body mass of (2.0±0.5) kg, with half males and half females, were randomly divided into blank group, model group, three massage groups(including massage for 10 min, 20 min, and 30 min group by random number table), 10 rabbits in each group. In addition to the blank group, CSA rabbit model was made by injection of sclerosing agent in other groups. The rabbits of massage for 10 min, 20 min, and 30 min groups received the massage therapy of corresponding duration, one times a day, continuous 10 days. The blood flow of vertebral artery in each group was detected by PeriFlux5000 laser doppler, and the contents of NPY and ET-1 in serum were detected by ELISA before and after treatment.</p><p><b>RESULTS</b>Changes in blood flow of vertebral artery before and after treatment:there was no significant difference between model group and massage for 10 min group;there was significant difference between model group and massage for 20, 30 min groups(<0.01); there was significant difference between massage for 10 min group and massage for 20, 30 min groups(<0.01); there was no significant difference between massage for 20 min group and massage for 30 min group. Changes of NPY content before and after treatment: there was significant difference between model group and massage for 10 min group(<0.05); there was significant difference between model group and massage for 20, 30 min groups(<0.01); there was significant difference between massage for 10 min group and massage for 20, 30 min groups(<0.01); there was no significant difference between massage for 20 min group and massage for 30 min group. Changes of ET-1 content before and after treatment:there was no significant difference between model group and massage for 10 min group;there was significant difference between model group and massage for 20, 30 min groups(<0.01); there was significant difference between massage for 10 min group and massage for 20 min, 30 groups (<0.01); there was no significant difference between massage for 20 min group and massage for 30 min group.</p><p><b>CONCLUSIONS</b>Massage needed 20 min for rabbits with CSA can only significantly improve the blood flow of vertebral artery. However, prolonging the time of massage has no obvious effect. The material basis of this timeliness characteristic of massage is closely related to the change of NPY and ET-1 levels in serum.</p>

Clinical research on the effect of gentongping pill combined with physiotherapy on the patients with vertebral artery type of cervical spondylosis / 中国生化药物杂志

Objective To analyze the effects of gentongping pill combined with physiotherapy on the patients with vertebral artery type of cervical spondylosis. Methods 134 patients with vertebral artery type of cervical spondylosis were grouped into two groups, the observation group and the control group. The two groups were treated with physiotherapy and the observation group was treated with Gentongping pill. The effects in the two groups were evaluated. Results The total efficiency in the observation group was higher than that in the control group(P<0.05). After treatment, the symptom score, CASCS score, mean blood flow velocity in left vertebral artery and right vertebral artery, TNF-α and IL-6 level in the observation group were better than those in the control group (all P<0.05). There was no obvious adverse reaction in the two groups. Conclusion Itcan improve the therapeutic effect which Gentongping pill is used on the treatment of patients with vertebral artery type of cervical spondylosis.

Clinical research of psychological intervention combined with celecoxib and physiotherapy on vertebral artery type of cervical spondylosis / 中国生化药物杂志

Objective To analyse effects of psychological intervention combined with celecoxib and physiotherapy on vertebral artery type of cervical spondylosis.Methods 134 patients with vertebral artery type of cervical spondylosis were grouped into two groups.Two groups were treated with physiotherapy and celecoxib,observation group was treated another with psychological intervention.Results Total efficiency of observation group was higher than that of control group(P<0.05).After treatment,symptom score,CASCS score,mean blood flow velocity in left vertebral artery and right vertebral artery,TNF-α and IL-6 level of observation group were better than that of control group(all P<0.05).During treatment, there was no obvious adverse reaction in the two groups.Conclusion Sychological intervention can improve the therapeutic effect of patients with cervical spondylosis of vertebral artery type.

Clinical Effects Evaluation of Huoxue Dingxuan Capsules in Treatment of Vertebral Artery Type of Cervical Spondylosis / 中国中医药信息杂志

Objective To observe the clinical effects of Huoxue Dingxuan Capsules on treatment of vertebral artery type of cervical spondylosis, and evaluate its efficacy and safety. Methods Totally 130 cases of vertebral artery type of cervical spondylosis were randomly assigned to treatment group and control group, and treated with Huoxue Dingxuan Capsules and Sibelium capsules respectively. Integration method was used to compare the differences of main symptoms and signs, the overall efficacy and safety were evaluated, and relapse after six months was followed up. Results Both groups had a significant effect on the improvement of signs and symptoms in vertebral artery type of cervical spondylosis, the total efficiency was 94.03%(63/67) in treatment group and 82.54% (52/63) in control group. The treatment group had a better effect on the overall efficacy and relieving symptoms and signs compared with the control group (P<0.01). The mean blood flow velocity had a significant change after treatment (P<0.05), and the treatment group was better than the control group (P<0.01). Within six months, the treatment group had 4 cases (6.34%) with mild recurrence of symptoms and signs, and the control group had 18 cases (34.61%), the difference between the two groups was statistically significant (P<0.05), and no severe recurrence was found. The two groups showed no side effects. Conclusion Huoxue Dingxuan Capsules is safe and effective for treating vertebral artery type of cervical spondylosis, and the long-term efficacy and subjects’ compliance are better than oral Sibelium capsules.

Effect of Buflomedil Injection plus Backward Traction and Functional Exercise on Hemorheology of Patients with Vertebral Artery Type of Cervical Spondylosis / 中国药房

OBJECTIVE:To observe the effect of Buflomedil Injection plus backwards traction and functional exercises on the hemorheology of patients with vertebral artery type of cervical spondylosis. METHODS:Sixty patients with vertebral artery type of cervical spondylosis were treated with 0.2 g Buflomedil Injection (diluted with 500 mL 0.9% Sodium Chloride Solution or 5% Glucose Solution,q.d by slow iv gtt for two courses of treatment with 7 days defined as 1 course) plus backwards traction and functional exercises. Patients' hemorheologic parameters including blood viscosity high shear rate,blood viscosity low shear rate,plasma viscosity,erythrocyte aggregation index,erythrocyte rigidity index,hematocrit,and fibrinogen etc were detected before and after treatment. RESULTS:Before treatment,all the hemorheologic parameters were significantly higher than the reference values of healthy adults(P

Effect of Rehabilitation by Integrated Traditional Chinese and Western Medicine on Cervical Spondylotic Vertebral Arteriopathy / 中国康复理论与实践

@#Objective To observe the effect of acupuncture therapy combined with medicine ion ducted by intermediate frequency electricity on vertebral artery type of cervical spondylosis.Methods60 patients with vertebral artery type of cervical spondylosis were divided into the acupuncture combined with medicine ion ducted by intermediate frequency electricity group (group A) and acupuncture group (group B) with 30 cases in each group. The group A was treated by acupuncture combined with medicine ion ducted by intermediate frequency electricity and the group B was treated by acupuncture only.ResultsThe cure rate and the efficiency rate were 70% and 93% in the group A, 33.3% and 90% in thegroup B respectively. The therapeutic effect of the group A was obviously superior to that of the group B ( P<0.05).ConclusionThe treatment of acupuncture combined with medicine ion ducted by intermediate frequency electricity shows an obvious effect on vertebral artery type of cervical spondylosis.

Effect of Biqi Capsule on vertebral artery type of cervical spondylosis / 中华中医药杂志

Objective:To observe the curative effect of the Biqi Capsule on vertebral artery type of cervical spondylosis. Methods:86 Patients of vertebral artery type of cervical spondylosis were treated with Biqi Capsule,10d for a course of treatment,the treatment lasted for 2-4 courses.The curative effect was observed. Results:After 2 courses,61 patients (70%) had complete remission of symptoms;20 patients (23%) had improved symptoms;5 patients (6%) was ineffective.The total effective rate was 94%.Conclusion:The Biqi Capsule had obvious effect on vertebral artery type of cervical spondylosis.